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Your Position: 홈 > Protein > CD47 > CD7-R5257

Rabbit CD47 Protein, Fc Tag

소개
QC & Assay Protocol
Citation & 백그라운드
  • 동의어
    CD47,MER6,IAP,OA3
  • 출처
    Rabbit CD47, Fc Tag (CD7-R5257) is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Glu 139 (Accession # G1SKT7).
    Predicted N-terminus: Gln 19
    Request for sequence
  • 분자 표징
    Online(Gln 19 - Glu 139) G1SKT7

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 40.4 kDa. As a result of glycosylation, the protein migrates as 48-58 kDa under reducing (R) condition, and 85-110 kDa and 160-220 kDa under non-reducing (NR) condition (SDS-PAGE).

  • 내독소
    Less than 1.0 EU per μg by the LAL method.
  • 순도

    >95% as determined by SDS-PAGE.

  • 레시피

    Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • 재구성

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 보관

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Rabbit CD47, Fc Tag (Cat. No. CD7-R5257) SDS-PAGE gel

Rabbit CD47, Fc Tag on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • 백그라운드
    Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.
  • Clinical and Translational Updates

  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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