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DLL3

요약

Name:Delta-like protein 3
Target Synonym:Delta-Like Protein 3,Delta3,Delta-Like 3,Drosophila Delta Homolog 3,SCDO1,Delta-Like 3 (Drosophila),DLL3,Delta (Drosophila)-Like 3,Delta Like Canonical Notch Ligand 3
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 2 Clinical

제품 리스트 비교 또는 구매

일부의 생물활성 데이터

DL3-C52H9-ELISA
Cynomolgus DLL3 (27-488), His TagCynomolgus DLL3 (27-488), His Tag (Cat. No. DL3-C52H9) ELISA bioactivity

Immobilized Cynomolgus DLL3 (27-488), His Tag (Cat. No. DL3-C52H9) at 1 μg/mL (100 μL/well) can bind Anti-DLL3 Antibody (specific Binding DSL of DLL3), Human IgG1 with a linear range of 0.1-3 ng/mL (QC tested).

DL3-H82F5-MALS-HPLC
DLL3 MALS images

The purity of Biotinylated Human DLL3, Fc,Avitag(Cat. No. DL3-H82F5) is more than 90% and the molecular weight of this protein is around 100-120 kDa verified by SEC-MALS.

Synonym Name

Delta3,delta-like 3 (Drosophila),delta-like protein 3,DLL3,Pudgy,SCDO1,SCDO1delta3

Background

Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands.May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 protein is expressed on the surface of tumor cells but not in normal adult tissues.

Clinical and Translational Updates

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
89Zr-DFO-SC16.56 89Zr-DFO-SC16.56 Phase 1 Clinical Memorial Sloan Kettering Cancer Center Small Cell Lung Carcinoma Details
AMG-119 AMG-119 Amgen Inc Details
HPN-328 HPN-328 Harpoon Therapeutics Details
QLS-31904 QLS31904; QLS-31904 Phase 1 Clinical Qilu Pharmaceutical Co Ltd Solid tumours Details
Tarlatamab AMG-757 Phase 2 Clinical Amgen Inc Small Cell Lung Carcinoma; Prostatic Neoplasms Details

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