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> Liver-related Solutions & Services
Explore our ready-to-use liver organoids, cells, kits, and services. Learn about our robust ready-to-use organoid and differentiation kits that undergo rigorous quality control, including cell viability assays, and enzyme activity testing. Our reliable services include liver organoid differentiation, disease modeling, and drug testing cater to the specific research needs.
Traditionally, drug hepatotoxicity evaluations rely on animal studies that have limitations such as high costs, long durations, and ethical concerns. However, liver organoids enable an in vitro simulation of drug toxicity effects, providing a rapid and accurate assessment for drug safety. Moreover, liver organoids can mimic the pathogenesis of various liver diseases such as hepatitis, liver cirrhosis, and liver cancer, aiding in early diagnosis and monitoring, as well as exploring treatment options.
Liver Organoids
Liver organoids are a miniaturized, in vitro version of the liver that is derived from induced pluripotent stem cells (iPSCs). These organoids are designed to have a similar cellular composition and architecture to the liver, reflecting human-specific drug metabolism. As such, liver organoids are critical tools for researchers, enabling personalized drug screening and replicating key hepatic functions while mimicking the physiological architecture of the liver.
Drug Screening
Drug Screening
Liver organoids derived from human cells mimic native liver tissue and have functional properties, enabling their application in a scalable, high-throughput drug screening including efficacy and toxicity assessments.
Liver Development Research
Liver Development Research
By utilizing liver organoids, researchers can investigate various biological events during liver development, such as cell differentiation, proliferation, migration, and apoptosis. These studies contribute significantly to uncovering the molecular mechanisms.
Personalized Medicine
Personalized Medicine
Defining a treatment strategy is the foundation of personalized medicine. Personalized medicine utilizing liver organoids has the potential to screen for therapeutic efficacy while minimizing side effects on an individual scale.
Liver organoids and differentiation kits are available to support high-throughput differentiation of liver organoids from iPSCs.
Bile duct epithelial marker (CK19) revelas typical hexagonal structure of hepatic lobule demonstrating a sigificant level of maturity and functionality similar to native liver tissue.
| Cat. No. | Description |
| CIPO-RWL005K | Ready-to-use Human iPSC-Derived Liver Organoids |
| RIPO-RWM009K | Human iPSC-Derived Liver Organoid Differentiation Kit |
| RIPO-RWM010 | Human iPSC-Derived Liver Organoid Maturation and Maintenance Kit |
Liver Cells
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Liver Services
We utilize specific cytokines and stimuli to induce reprogramming or differentiation of iPSC or human tissue. The differentiation and maturation of organoids are identified by the expression of liver-related protein markers.
We measure the inhibition of CYP450 expression and enzyme activity under the action of the drug, since the ALB secreted into the medium also represents the liver activity.
We can help to construct the AD/PD model with PFFs and provide corresponding pathological findings and biochemical evidence. At the same time, we can also provide you with follow-up drug screening services.
Liver Case Studies
NASH, a chronic liver disease characterized by fat accumulation, inflammation, and liver damage, is closely associated with obesity, type 2 diabetes, and metabolic syndrome. Oil Red is a dye used to detect intracellular lipid deposition, effectively visualizing fatty acid accumulation in liver organoids.
Troglitazone, known for its severe hepatotoxicity, is often used as a compound to induce liver injury in vitro. AO/PI staining is a common fluorescence method for assessing cell viability and death, allowing rapid distinction between live (green) and dead cells (red), making it useful for evaluating drug-induced cytotoxicity.
Cholestasis, a common hepatotoxic response, can be effectively monitored using 5-carboxy-2',7'-dichlorofluorescein diacetate (CDFDA). This non-fluorescent probe is metabolized by hepatocyte esterases into fluorescent CDF, which is normally secreted via bile transporters. During cholestasis, impaired biliary excretion causes CDF accumulation in hepatocytes, serving as a sensitive functional marker for bile flow obstruction.
References
1. Kulkeaw, K.; Pengsart, W. Progress and Challenges in the Use of a Liver-on-a-Chip for Hepatotropic Infectious Diseases. Micromachi nes 2021, 12, 842. https://doi.org/10.33 90/mi12070842.
2. akebe, T., Sekine, K., Enomura, M. et al. Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature 499, 481–484 (2013).
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