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> 백신 개발용 시약
2019년 12월, 새로운 유형의 코로나바이러스인 SARS-CoV-2가 전 세계적으로 빠르게 확산되기 시작하여 전 세계적인 COVID-19 대유행을 일으켰습니다. 그 결과 (2021년 11월 기준)2억 명 이상의 사람들이 새로운 코로나바이러스 진단을 받았으며, 거의 500만 명이 사망했습니다. 코로나바이러스는 전 세계 사람들의 생명과 건강에 큰 위협이 될 뿐만 아니라 전 세계 국가의 사회 안정과 경제 발전에 거대한 영향을 미치고 있습니다.
그뿐만 아니라 전 세계적으로 코로나바이러스 감염증(코로나19)이 만연하는 과정에서 코로나바이러스 변이주의 지속적인 출현으로 어려움이 더욱 가중되었습니다. 현재 세계보건기구(WHO)는 Alpha （B.1.1.7)、 Beta （B.1.351）、Gamma（P.1）밎Delta（B.1.617.2）을 포함한 전파력이나 면역회피능력이 더 강한 4개의 변이주를 "특별한 주의가 필요한 변이주(VOC)"로 지정하였습니다. 그 중 Beta와 Gamma 바이러스주는 강한 면역 탈출 능력을 가지고 있고 Alpha와 Delta 돌연변이 바이러스주는 강한 전염력과 강한 면역 탈출 능력을 가지고 있습니다. 현재 Delta 돌연변이 바이러스주가 점차 세계적으로 주요 바이러스주가 되었지만 Lambda(C.37), Mu(B.1.621) 및 C.1.2와 같은 새로운 돌연변이 바이러스주도 지속적으로 등장하고 있습니다.
백신 접종은 전염병의 확산을 예방하고 통제하는 초석입니다. 마스크 착용과 사회적 거리두기의 중요성에도 불구하고 백신을 통한 예방접종은 여전히 우리의 건강을 보호하는 가장 효율적인 방법입니다. 그리하여 백신 개발과 생산은 각국의 공중보건정책의 핵심입니다.
ACROBiosystems 는 글로벌 백신 산업에 시약을 공급하는 생명과학 기업입니다. 대유행 시작한 후에, 우리는 SARS-CoV-2 재조합 항원의 연구 및 개발에 집중했으며 바이러스 및 백신에 대한 성숙한 기술과 경험을 축적하여 SARS-CoV의 모든 지배적 바이러스주를 포괄하는 200개 이상의 제품 및 맞춤형 서비스를 제공허며 백신 개발을 위한 모든 기술 플랫폼을 지원합니다.
>>> 코로나바이러스 돌연변이 항원 단백질 및 관련 제품 보러가기
위협적인 코로나바이러스에 직면하여 백신은 전염병을 예방하고 통제하기 위한 가장 효과적이고 경제적인 공중 보건 조치 중 하나입니다. 코로나바이러스의 감염 및 전파를 효과적으로 예방할 수 있는 백신을 개발하고 돌연변이 바이러스주에 대한 유효성을 지속적으로 평가하는 것이 매우 중요합니다.
바이러스가 발병한 후 1년여 동안 각 과학 연구 기관과 백신 회사는 이미 여러 종류의 백신을 성공적으로 개발해 냈다.백신은 서로 다른 기술 플랫폼에 따라 전 바이러스 백신, 아단위 백신, 바이러스 캐리어 백신과 유전자 백신으로 나눌 수 있다(그림1). 현재 세계보건기구(WHO)로부터 전 세계적으로 대규모 백신 접종에 사용할 수 있는 긴급사용 승인을 받은 백신 7종이 있습니다. 그리고 300여종 백신 개발 중이며 임상 전 또는 임상시험 단계에 있다.
불활성화 백신/재조합 단백질 백신: SDS-PAGE, MS, ELISA;
바이러스 벡터 백신/핵산 백신: Western Blot, FACS;
재조합 단백질 백신: ELISA, SPR, BLI
IgG 역가 검출：ELISA Neutralizing Ab titer detection cVNT, pVNT, sVNT.
①생체내 효력 시험:
★체액 면역:
Ⅰ 동물 혈청 내 총 항체 검출: 간접 ELISA
Ⅱ 동물혈청중화항체 검출 : cVNT, pVNT, sVNT (competitive ELISA)
★세포면역 : Elispot
①체액면역(항체아형검출) : 간접 ELISA
②세포성 면역(특정 T 세포 및 사이토카인 검출) : 엘리스팟
①생체내 효능 시험:
★체액 면역:
Ⅰ 인간 혈청 내 총 항체 검출: 간접 ELISA
Ⅱ 인간혈청중화항체 검출 : cVNT, pVNT, sVNT (competitive ELISA)
★세포면역 : 엘리스팟
②체외역가검출 : 백신항원함량 : 이중 항체 샌드위치 ELISA
③동물보호시험 : 동물챌린지보호시험
①체액면역(항체아형검출) : 간접 ELISA
②세포성 면역(특정 T 세포 및 사이토카인 검출) : 엘리스팟
매우 안정적인 SARS-CoV-2 스파이크 삼량체
RBD/S 트리머 항원 정량 검출 키트
변이 특이적 항체
SDS-PAGE 및 MS 항원 검출을 위한 고순도 표준물질 : 매우 안정적인 SARS-CoV-2 스파이크 삼량체
| 리니지 | 제품 번호 | 돌연변이 사이트 | 태그 | 주문/선주문 |
|---|---|---|---|---|
| SARS-CoV-2 Wild Type | SPN-C52H9 | NA | His Tag | |
| SPN-C82E9 | NA | His & Avitag™ | ||
| SARS-CoV-2 OmicronNEW B.1.1.529 | SPN-C82Ee | A67V, HV69-70del, T95I, G142D, VYY143-145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F | His Tag & Avi Tag | |
| SPN-C52Hz | A67V, HV69-70del, T95I, G142D, VYY143-145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F | His Tag | ||
| SARS-CoV-2 Delta | B.1.617.2 | SPN-C52He | T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N | His Tag | |
| SPN-CR2H7 | T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N | His Tag | ||
| SPN-C82Ec | T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N | His & Avitag™ | ||
| SARS-CoV-2 Delta Plus | AY.1 | AY.2 | AY.3 | SPN-C52Ht | T19R, V70F, FR157-158Del, A222V, W258L, K417N, L452R, T478K, D614G, P681R, D950N | His Tag | |
| SPN-C82Ei | T19R, V70F, FR157-158Del, A222V, W258L, K417N, L452R, T478K, D614G, P681R, D950N | His & Avitag™ | ||
| SARS-CoV-2 Lambda | C.37 | SPN-C52Hs | G75V, T76I, SYLTPGD 247-253 del, L452Q, F490S, D614G, T859N | His Tag | |
| SPN-C82Eh | G75V, T76I, SYLTPGD 247-253 del, L452Q, F490S, D614G, T859N | His & Avitag™ | ||
| SARS-CoV-2 C.1.2 | SPN-C52Hb | C136F, Y144del, R190S, D215G, LA242-243del, Y449H, E484K, N501Y, D614G, H655Y, N679K, T716I, T859N | His Tag | |
| SPN-C82Eq | C136F, Y144del, R190S, D215G, LA242-243del, Y449H, E484K, N501Y, D614G, H655Y, N679K, T716I, T859N | His & Avitag™ | ||
| SARS-CoV-2 Mu | B.1.621 | SPN-C52Ha | T95I, Y144S, Y145N, R346K, E484K, N501Y, D614G, P681H, D950N | His Tag | |
| SPN-C82Ek | T95I, Y144S, Y145N, R346K, E484K, N501Y, D614G, P681H, D950N | His & Avitag™ | ||
| SARS-CoV-2 Alpha | B.1.1.7 | SPN-C52Hp | N501Y, D614G | His Tag | |
| SPN-C52H6 | HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H | His Tag | ||
| SPN-C82E5 | HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H | His & Avitag™ | ||
| SARS-CoV-2 Beta | B.1.351 | SPN-C52Hk | L18F, D80A, D215G, 242-244del, R246I, K417N, E484K, N501Y, D614G, A701V | His Tag | |
| SPN-C82E4 | L18F, D80A, D215G, 242-244del, R246I, K417N, E484K, N501Y, D614G, A701V | His & Avitag™ | ||
| SPN-C52Hm | K417N, D614G | His Tag | ||
| SPN-C52Hq | E484K, D614G | His Tag | ||
| SARS-CoV-2 Gamma | P.1 | SPN-C52Hg | L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F | His Tag | |
| SPN-C82E6 | L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F | His & Avitag™ | ||
| SPN-C52Hn | K417T, D614G | His Tag | ||
| SPN-C52Hq | E484K, D614G | His Tag | ||
| SARS-CoV-2 Kappa | B.1.617.1 | SPN-C52Hr | T95I, G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H | His Tag | |
| SPN-C82E7 | T95I, G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H | His & Avitag™ | ||
| SARS-CoV-2 B.1.620 | SPN-C52Hh | P26S, HV69-70del, V126A, Y144del, LLA241-243del, H245Y, S477N, E484K, D614G, P681H, T1027I, D1118H | His Tag | |
| SPN-C82Ed | P26S, HV69-70del, V126A, Y144del, LLA241-243del, H245Y, S477N, E484K, D614G, P681H, T1027I, D1118H | His & Avitag™ | ||
| SARS-CoV-2 D614G | SPN-C52H3 | D614G | His Tag | |
| SPN-CR2H3 | D614G | His Tag | ||
| SPN-C82E3 | D614G | His & Avitag™ | ||
| SPN-C52Hm | K417N, D614G | His Tag | ||
| SPN-C52Hn | K417T, D614G | His Tag |
The purity of SARS-CoV-2 S protein, His Tag, Super stable trimer (Cat. No. SPN-C52H9) is more than 90% verified by SDS-PAGE under reducing (R) condition. The molecular weight was around 550-660 kDa confirmed by SEC-MALS. The particles are similar in size and appearance to SARS-CoV-2 trimers reported in published literature verified by negative stain electron micrography.
SARS-CoV-2 S protein, His Tag, Super stable trimer (Cat. No. SPN-C52H9) shows highest signal-to-noise ratio as compared to other spike proteins constructs in antibody tests in convalescent serum
항원 함량 지표의 효율적인 획득 :RBD/S 트리머 항원 정량 검출 키트(이중 항체 샌드위치 ELISA)
| 제품 번호 | 제품 설명 | 테스트 샘플 | 주문/선주문 |
|---|---|---|---|
| RAS-A010 | SARS-CoV-2 Nucleocapsid Protein Titer Assay Kit | Vaccine samples | |
| RAS-A020 | SARS-CoV-2 Spike Protein Titer Assay Kit | Vaccine samples | |
| RAS-A021 | SARS-CoV-2 Spike RBD Titer Assay Kit | Vaccine samples | |
| RAS-A039 | SARS-CoV-2 Spike Protein ELISA Kit (For Vaccine Development) | Vaccine samples | |
| RAS-A050 | SARS-CoV-2 Spike RBD ELISA Kit (For Vaccine Development) | Vaccine samples | |
| RAS-A071 | SARS-CoV-2 Spike Trimer (B.1.1.529) ELISA Kit (For Vaccine Development) | Vaccine samples | |
| RAS-A072 | SARS-CoV-2 Spike RBD (B.1.1.529) ELISA Kit (For Vaccine Development) | Vaccine samples |
차세대 백신 R&D에서 돌연변이 항원 검출용: Omicron/Delta/Beta & Gamma 특이적 항체
| 제품 번호 | 제품 설명 | 아이소타입 컨트롤 | 에피토프 | 주문/선주문 |
|---|---|---|---|---|
| SPD-M305 | Anti-SARS-CoV-2 Spike RBD Antibody, Mouse IgG1 (Omicron Specific) | Mouse IgG1 | Spike RBD | |
| SPD-M110 | Anti-SARS-CoV-2 Spike RBD Antibody, Mouse IgG1 (Delta Specific) | Mouse IgG1 | Spike RBD | |
| SPD-M416 | Anti-SARS-CoV-2 Spike RBD Antibody, Mouse IgG1 (AM416) (Beta & Gamma Specific) | Mouse IgG1 | Spike RBD | |
| SPD-M334 | Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (AM416) (Beta & Gamma Specific) (MALS verified) | Human IgG1 | Spike RBD |
Loaded Monoclonal Anti-SARS-CoV-2 Spike RBD Antibody, Mouse IgG1 (Cat. No. SPD-M305) on AMC Biosensor, can bind SARS-CoV-2 Spike RBD, His Tag (B.1.1.529/Omicron) (Cat. No. SPD-C522e) with an affinity constant of 9.07 nM as determined in BLI assay (ForteBio Octet Red96e).
Immobilized SARS-CoV-2 Spike RBD (Omicron, Cat.No. SPD-C522e) can bind Anti-SARS-CoV-2 Spike RBD Antibody, Mouse IgG1(Cat.No.SPD-M305) with a linear range of 0.4-12.5 ng/mL. The antibody does not bind Spike RBD of WT (Cat.No. SPD-C52H1), Alpha (Cat.No. SPD-C52Hn), Beta (Cat.No. SPD-C52Hp), Delta(Cat.No. SPD-C52Hh) and Gamma (Cat.No. SPD-C52Hr).
고품질 ACE2 수용체 단백질
Antigen-ACE2 상호작용 서비스
항원 활성 검증 천연 이량체 리간드:고품질 ACE2 수용체 단백질
| 분자 | 제품 번호 | 종 | 태그 | 숙주 | 제품 설명 | 주문/선주문 |
|---|---|---|---|---|---|---|
| ACE2 | AC2-H82E6 | Human | His Tag & Avi Tag | HEK293 | Biotinylated Human ACE2 / ACEH Protein, His,Avitag™ (MALS verified) | |
| AC2-H5257 | Human | Fc Tag | HEK293 | Human ACE2 / ACEH Protein, Fc Tag (MALS verified) | ||
| AC2-H82F9 | Human | Fc Tag & Avi Tag | HEK293 | Biotinylated Human ACE2 / ACEH Protein, Fc,Avitag™ | ||
| AC2-H52H8 | Human | His Tag | HEK293 | Human ACE2 / ACEH Protein, His Tag (MALS verified) | ||
| AC2-H5205 | Human | Mouse IgG1 Fc Tag | HEK293 | Human ACE2 / ACEH Protein, Mouse IgG1 Fc Tag (MALS verified) | ||
| AC2-H82E8 | Human | His Tag & Avi Tag | HEK293 | Biotinylated Human ACE2 / ACEH Protein, His,Avitag™ | ||
| AC2-P5248 | Paguma larvata | His Tag | HEK293 | Paguma larvata ACE2 / ACEH Protein, His Tag (SPR verified) | ||
| AC2-M5248 | Mouse | His Tag | HEK293 | Mouse ACE2 / ACEH Protein, His Tag (MALS verified) | ||
| AC2-C52H7 | Cynomolgus | His Tag | HEK293 | Cynomolgus ACE2 / ACEH Protein, His Tag | ||
| AC2-R5246 | Rat | His Tag | HEK293 | Rat ACE2 / ACEH Protein, His Tag (MALS verified) | ||
| Neuropilin-1 | NR1-H5228 | Human | His Tag | HEK293 | Human Neuropilin-1 / NRP1 / CD304 Protein, His Tag | |
| NR1-H5252 | Human | Fc Tag | HEK293 | Human Neuropilin-1 / NRP1 / CD304 Protein, Fc Tag | ||
| NR1-H82E3 | Human | His Tag & Avi Tag | HEK293 | Biotinylated Human Neuropilin-1 / NRP1 / CD304 Protein, His,Avitag™ | ||
| NR1-M5254 | Mouse | Mouse IgG2a Fc Tag | HEK293 | Mouse Neuropilin-1 / NRP1 / CD304 Protein, Mouse IgG2a Fc Tag, low endotoxin | ||
| ASGR1 | AS1-H5253 | Human | Fc Tag | HEK293 | Human ASGR1/ASGPR1 Protein, Fc Tag | |
| KREMEN1 | KR1-H5253 | Human | Fc Tag | HEK293 | Human Kremen-1 protein, Fc Tag |
Immobilized SARS-CoV-2 S1 protein, His Tag (Cat. No. S1N-C52H3) at 2 μg/mL (100 μL/well) can bind Biotinylated Human ACE2, His,Avitag (Cat. No. AC2-H82E6) with a linear range of 2-20 ng/mL (QC tested).
Human ACE2, Fc Tag (Cat. No. AC2-H5257) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind recombinant SARS-CoV-2 Spike vaccine with an affinity constant of 16.9 nM as determined in a SPR assay (Biacore T200).
Antigen-ACE2 상호작용에 대한 종합 연구 지원: 분자 상호작용 분석 서비스
>>> 단백질은 MALS 통해 고순도가 검증되었고, in vitro 및 cellular assay를 통해 생물학적 활성이 높은 것으로 확인되었습니다. 자세히 알아보려면 클릭하세요.
>>> SARS-CoV-2(COVID-19) 관련 제품 개발에 대한 맞춤형 문의나 제안이 있는 경우 여기를 클릭하십시오.
항체 역가 검출
중화 항체 역가 검출
넓은 스펙트럼의 RBD 단백질 중화 항체
백신 개발 전 단계(동물 및 인간)에서 생체 내 역가 검출 요구를 충족 :S trimer/RBD/S1 IgG 항체 역가 검출 키트(간접 ELISA)
| 신청 | 제품번호 | 항원 | 테스트 샘플 | 제품 설명 | 주문/선주문 |
|---|---|---|---|---|---|
| Preclinical trial | RAS-T018 | Spike RBD | Mouse Serum | Mouse Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit | |
| RAS-T023 | Spike Trimer | Mouse Serum | Mouse Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike Trimer) | ||
| RAS-T019 | Spike RBD | Monkey Serum | Monkey Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit | ||
| RAS-T059 | SARS-CoV-2 OmicronNEW B.1.1.529 | Mouse Serum | Mouse Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike RBD) | ||
| RAS-T060 | Mouse Serum | Mouse Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike Trimer) | |||
| RAS-T061 | Mouse Serum | Mouse Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike S1) | |||
| RAS-T062 | Monkey Serum | Monkey Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike RBD) | |||
| RAS-T063 | Monkey Serum | Monkey Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike Trimer) | |||
| RAS-T064 | Monkey Serum | Monkey Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike S1) | |||
| RAS-T070 | Delta | B.1.617.2 (India) | Mouse Serum | Mouse Anti-SARS-CoV-2 (B.1.617.2) Antibody IgG Titer Serologic Assay Kit (Spike Trimer) | ||
| Clinical trial | RAS-T024 | Spike RBD | Human Serum | Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike RBD) | |
| RAS-T025 | Spike Trimer | Human Serum | Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike Trimer) | ||
| RAS-T001 | Spike S1 | Human Serum | Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike S1) | ||
| RAS-T008 | Nucleocapsid Protein | Human Serum | Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (Nucleocapsid Protein) | ||
| RAS-T009 | Spike RBD | Human Serum | Anti-SARS-CoV-2 Total Antibody Titer Serologic Assay kit (Spike RBD) | ||
| RAS-T026 | Alpha (B.1.1.7) Spike RBD | Human Serum | Anti-SARS-CoV-2 (B.1.1.7) Antibody IgG Titer Serologic Assay Kit (Spike RBD) | ||
| RAS-T027 | Alpha (B.1.1.7) Spike protein | Human Serum | Anti-SARS-CoV-2 (B.1.1.7) Antibody IgG Titer Serologic Assay Kit (Spike Protein) | ||
| RAS-T029 | Beta (B.1.351) Spike RBD | Human Serum | Anti-SARS-CoV-2 (B.1.351) Antibody IgG Titer Serologic Assay Kit (Spike RBD) | ||
| RAS-T030 | Beta (B.1.351) Spike protein | Human Serum | Anti-SARS-CoV-2 (B.1.351) Antibody IgG Titer Serologic Assay Kit (Spike Protein) | ||
| RAS-T032 | Gamma (P.1) Spike RBD | Human Serum | Anti-SARS-CoV-2 (P.1) Antibody IgG Titer Serologic Assay Kit (Spike RBD) | ||
| RAS-T033 | Gamma (P.1) Spike protein | Human Serum | Anti-SARS-CoV-2 (P.1) Antibody IgG Titer Serologic Assay Kit (Spike Protein) | ||
| RAS-T057 | OmicronNEW B.1.1.529 (South Africa) | Human Serum | Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike RBD) | ||
| RAS-T058 | Human Serum | Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)) | |||
| RAS-T069 | Human Serum | Anti-SARS-CoV-2 (B.1.1.529) Total Antibody Titer Serologic Assay Kit (Spike RBD) |
Post-vaccination serum samples are tested with Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike RBD) (Cat.No.RAS-T024), which accurately and precisely measure antibody titer in serum (Accuracy≤±15%; Intra-assay precision<10%; Inter-assay precision <15%).
Anti-SARS-CoV-2 Antibody IgG Quantitative Detection Kit (Spike Trimer) (Cat. No. RAS-T048) is developed for quantitative detection of IgG antibodies in post-vaccination serum. This kit is an important supplement to the existing vaccine evaluation methods which significantly improve the efficiency and accuracy of vaccine evaluation.
고처리량 중화 항체 검출의 편리한 대안 :특정 중화 항체 역가 키트(competitive ELISA)
| 리니지 | 제품 번호 | 제품 설명 | 테스트 샘플 | 주문/선주문 |
|---|---|---|---|---|
| SARS-CoV-2 Wild Type | RAS-N022 | Anti-SARS-CoV-2 Neutralizing Antibody Titer Serologic Assay Kit | Human Serum | |
| SARS-CoV-2 Alpha | B.1.1.7 | RAS-N028 | Anti-SARS-CoV-2 (B.1.1.7) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD) | Human Serum | |
| SARS-CoV-2 Beta | B.1.351 | RAS-N031 | Anti-SARS-CoV-2 (B.1.351) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD) | Human Serum | |
| SARS-CoV-2 Gamma | P.1 | RAS-N034 | Anti-SARS-CoV-2 (P.1) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD) | Human Serum | |
| SARS-CoV-2 Delta | B.1.617.2 | RAS-N040 | Anti-SARS-CoV-2 (B.1.617.2) Neutralizing Antibody Serologic Assay Kit (Spike RBD) | Human Serum | |
| RAS-N041 | Anti-SARS-CoV-2 (B.1.617.2) Neutralizing Antibody Serologic Assay Kit (Spike Trimer) | Human Serum | ||
OmicronNEW B.1.1.529 (South Africa) | RAS-N056 | Anti-SARS-CoV-2 (B.1.1.529) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD) | Human Serum |
Competitive ELISA
Post-vaccination serum NAb test (Cat. No. RAS-N022) demonstrates high sensitivity and accuracy
16 convalescent serum samples were tested for neutralizing antibody level with pseudovirus and ELISA kit (Cat. No. RAS-N022), respectively. The results are highly correlated (R2 =93.73)。
56 post-vaccination (inactivated vaccines) serum samples are tested for neutralizing capacity against multiple strains (Alpha, Beta, Gamma, Delta) of SARS-CoV-2 with wild type (WT) and mutant-specific kits. Neutralization against all VOCs is lower than the WT, with Delta being the lowest.
Note：y = (A - D) / [1 + (x/C)^B] + D (A =1.55562 B =1.45522 C=14.42024 D=0.05532 r^2= 1)
중화항체 검출을 위한 진정한 품질관리:넓은 스펙트럼의 RBD 단백질 중화 항체
| 제품 번호 | 종 | 항체 아형 | 제품 설명 | 주문/선주문 |
|---|---|---|---|---|
| S1N-M122 | Mouse | Human IgG1 | Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM122) | |
| SPD-M265 | Human | Human IgG1 | Anti-SARS-CoV-2 Spike RBD Broadly Neutralizing Antibody, Human IgG1 | |
| SPD-M180 | Human | Human IgG1 | Anti-SARS-CoV-2 RBD Potent Neutralizing Antibody, Human IgG1 (AM180） | |
| SAD-S35 | Human | Human IgG1 | Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Human IgG1 (AS35) | |
| SPD-M128 | Mouse | Human IgG1 | Anti-SARS-CoV-2 RBD Potent Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM128) | |
| SPD-M162 | Mouse | Human IgM | Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgM (AM122) | |
| SPD-M121 | Mouse | Human IgG1 | Anti-SARS-CoV-2 Spike NTD Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM121) | |
| S1N-VM226 | Mouse | Human IgG1 | Biotinylated Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM122) | |
| SPD-M201 | Cynomolgus | Cynomolgus IgG1 | Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Cynomolgus IgG1 (AM122) | |
| SPD-M58P1 | Mouse | Human IgA1 | Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgA1 (AM122) | |
| SPD-PM226 | Mouse | Human IgG1 | PE-Labeled Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM122) |
Anti-SARS-CoV-2 Spike RBD Neutralizing antibody (Cat.No.S1N-M122)neutralizes SARS-CoV-2 Spike RBD by inhibiting RBD: ACE2 interaction. The ACE2-coated plate is incubated with the wild type (WT) RBD or B.1.1.7, B.1.351, P.1, B.1.617.1, B.1.617.2 mutant and treated with the neutralizing antibody at increasing concentration. Percent inhibition is calculated based on the OD value.
As verified by SARS-CoV-2 spike pseudovirus neutralization test, the broad-spectrum neutralizing antibody (Cat. No. S1N-M122) can effectively neutralize wild-type and Alpha (B.1.1.7) /Beta (B.1.351) /Gamma (P.1) /Delta (B.1.617.2, data not shown) viral mutants, making it suitable as a quality control antibody in neutralizing antibody screening for mutant strains, neutralizing antibody detection in convalescent or vaccinated serum, etc.
항체 아형 검출 키트
ADE 및 VED 연구의 주요 결과를 신속하게 획득:편리한 고처리량 IgG 항체 아형 검출 키트(간접 ELISA)
| 제품 번호 | 제품 설명 | 테스트 샘플 | 주문/선주문 |
|---|---|---|---|
| RAS-T014 | Anti-SARS-CoV-2 Antibody IgG1 Titer Serologic Assay kit | Human Serum | |
| RAS-T015 | Anti-SARS-CoV-2 Antibody IgG2 Titer Serologic Assay kit | Human Serum | |
| RAS-T016 | Anti-SARS-CoV-2 Antibody IgG3 Titer Serologic Assay kit | Human Serum | |
| RAS-T017 | Anti-SARS-CoV-2 Antibody IgG4 Titer Serologic Assay kit | Human Serum | |
| RAS-T065 | Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG1 Titer Serologic Assay Kit (Spike RBD) | Human Serum | |
| RAS-T066 | Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG2 Titer Serologic Assay Kit (Spike RBD) | Human Serum | |
| RAS-T067 | Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG3 Titer Serologic Assay Kit (Spike RBD) | Human Serum | |
| RAS-T068 | Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG4 Titer Serologic Assay Kit (Spike RBD) | Human Serum |
Cross-validation data for antibody subtype detection
Authors: Sasisekharan, Varun et al.
Journal: Proc Natl Acad Sci U S A 2021
Cited Product: SPD-C52H3 ,NUN-C5227
Application: ELISA
Authors: Esparza, Thomas J et al.
Journal: Scientific reports 2020
Cited Product: S1N-C5255,AC2-H52H8,SPD-C52H3,SPD-C52H3,SPD-C82E9,AC2-H82E6,SPD-S52H7,SPD-S52H4
Application: Immunization, Competitive Immunopanning, SPR & Binding Assay & Phage Display Clone Screening, BLI, Binding Assay
Antibody Signature Induced by SARS-CoV-2 Spike Protein Immunogens in Rabbits
Authors: Ravichandran S, Coyle EM, Klenow L, et al.
Journal: Sci Transl Med 2020
Cited Product: AC2-H52H8
Application: SPR
Antibody-like proteins that capture and neutralize SARS-CoV-2
Authors: Kondo T, Iwatani Y, Matsuoka K, et al.
Journal: Science advances 2020
Cited Product: S1N-S52H5
Application: ELISA
Binding of the SARS-CoV-2 Spike Protein to Glycans
Authors: Wei Hao,et al
Journal: BioRxiv (preprint) 2020
Cited Product: S1N-C52H3
Application: glycan microarray
Authors: Yan Lou. et al
Journal: BioRxiv (preprint) 2020
Cited Product: S1N-C52H4,SPD-S52H4,SPD-S52H5,SPD-S52H7,SPD-S52H8
Application: BLI,ELISA
Authors: Tyler N Starr, Allison J Greaney , Sarah K Hilton, et al.
Journal: BioRxiv (preprint) 2020
Cited Product: AC2-H82E6
Application: Flow cytometry
Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection
Authors: Kaneko N, Satta S, Komuro Y, et al.
Journal: Stroke 2020
Cited Product: S1N-C82E8
Application: ELISA
HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry
Authors: Wei C, Wan L, Yan Q, et al.
Journal: Nature metabolism 2020
Cited Product: SPN-C52H9,S1N-C52H3,S2N-C52H5,SPD-C52H3
Application: SPR & FACS & Confocal microscopy
Human Hematopoietic Stem, Progenitor, and Immune Cells Respond Ex Vivo to SARS-CoV-2 Spike Protein
Authors: Ropa, James et al.
Journal: Stem cell reviews and reports 2020
Cited Product: SPN-C52H8 (This product has been taken off the shelves. An optimized version SPN-C52H9 has been launched.)
Application: Colony Forming Unit (CFU)
Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19
Authors: Tosif S, Neeland MR, Sutton P, et al.
Journal: Nature communications 2020
Cited Product: S1N-S52H5,S2N-C52H5,S1N-C52H3
Application: ELISA\FACS
Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults
Authors: Mulligan, Mark J et al.
Journal: Nature 2020
Cited Product: SPD-C82E9
Application: Immunogenicity assessments
SARS-CoV-2 exposure, symptoms and seroprevalence in healthcare workers in Sweden
Authors: Rudberg AS, Havervall S, Månberg A, et al.
Journal: Nat Commun 2020
Cited Product: NUN-C5227
Application: Luminex
Authors: Luetkens T, Metcalf R, Planelles V, et al.
Journal: Blood Adv 2020
Cited Product: S1N-C52H3
Application: ELISA
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