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Your Position: 홈 > Antibody > Claudin-18.2 > HCB-Y126

Monoclonal Anti-Claudin-18.2 Antibody, Mouse IgG1 (3B10)

INTRODUCTION
QC & Assay Protocol
Citation & Background
  • Background
    The Claudin-18.2 (CLDN 18.2) protein, an isoform of Claudin 18, a member of the tight junction protein family, is a highly selective biomarker with limited expression in normal tissues and often abnormal expression during the occurrence and development of various primary malignant tumors, such as gastric cancer/gastroesophageal junction (GC/GEJ) cancer, breast cancer, colon cancer, liver cancer, head and neck cancer, bronchial cancer and non-small-cell lung cancer. Claudin-18.2 participates in the proliferation, differentiation and migration of tumor cells. Recent studies have identified Claudin-18.2 expression as a potential specific marker for the diagnosis and treatment of these tumors.
  • Host Species

    Mouse

  • Clone

    3B10

  • Application

    IHC

  • Property
    1：1000
  • State
    Liquid
  • Positive Control
    Human Stomach Tissues
  • Clonality
    Monoclonal
  • Synonym
    Claudin18.2, CLDN 18.2
  • Research Field
    Cancer Drug Targets
  • Source
    Mouse
  • Isotype
    IgG
  • Storage
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Typical Data
Control Sample
Claudin-18.2 CONTROL SAMPLE

Immunohistochemical analysis of paraffin-embedded human stomach tissue labeling Claudin-18.2 with HCB-Y126 at 1/1000 dilution, followed by Goat Anti-Rabbit IgG H&L (HRP) ready to use. Membranous staining on human gastric epithelial cells is observed. Counter stained with Hematoxylin. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Claudin-18.2 CONTROL SAMPLE

Immunohistochemical analysis of paraffin-embedded human lung tissue labeling Claudin-18.2 with HCB-Y126 at 1/1000 dilution, followed by Goat Anti-Rabbit IgG H&L (HRP) ready to use. The staining in the lung tissue sample was negative. Counter stained with Hematoxylin. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Cancer Sample
Claudin-18.2 CANCER SAMPLE Claudin-18.2 CANCER SAMPLE Claudin-18.2 CANCER SAMPLE Claudin-18.2 CANCER SAMPLE

Immunohistochemical analysis of paraffin-embedded human cancer tissue labeling Claudin-18.2 with HCB-Y126 at 1/1000 dilution, followed by Goat Anti-Rabbit IgG H&L (HRP) ready to use. Membranous staining on tumor cells is observed. Counter stained with Hematoxylin. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

  • Clinical and Translational Updates

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재고상품 도착 날짜: 영업일 기준 4일

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