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Ready-to-use Human iPSC-Derived Cardiac Organoids

  • Product Details
    Cardiac organoids are three-dimensional in vitro models with a cellular composition and structural organization that is representative of the human heart. Human iPSC-Derived Cardiac Organoids are differentiated from human iPSCs using Human iPSC-Derived Cardiac Organoid Differentiation Kit (Catalog No#: RIPO-HWM002K). Differentiation was carried out by forming EBs from PSC at an ultra-low attachment interface, and then changing the medium according to the instructions. A spontaneously beating cardiac organoid with a cavity can be seen between days 9 and 13 of the onset of differentiation. Cardiomyocytes, key cellular component of cardiac organoid, are responsible for the beating of the cardiac organoids. The beating rate of the formed cardiac organoids increases dramatically when stimulated with isoproterenol or forskolin, and there is a linear relationship between the concentration of the drug and the beating rate over a range of concentrations.
  • Product Specification
    The live organoids are ready-to-use organoids that are delivered in shipping medium and has to go through a 48h recovery process according to instruction.
  • Storage

    After recovery, please store the organoid in its maintenance medium under the correct incubation condition and medium changing process.

Product Diagram
 - PRODUCT DIAGRAM

Protocol Diagram of cardiac organoid differentiation.

Validation Data
Organoid Histology and State
 - Organoid Histology And State

The cardiac organoids differentiated using the Human iPSC-Derived Cardiac Organoid Differentiation Kit (Ca. No. RIPO-HWM002K) show regular beating from day 7-13 of differentiation.

Marker Expression
 - MARKER EXPRESSION

The cardiac organoids differentiated using the Human iPSC-Derived Cardiac Organoid Differentiation Kit (Ca. No. RIPO-HWM002K) demonstrate the expression of cardiomyocyte marker cTnT (green).

Organoid Activity
 - ORGANOID ACTIVITY

The electrical activity of the cardiac organoids differentiated using the Human iPSC-Derived Cardiac Organoid Differentiation Kit (Ca. No. RIPO-HWM002K) was recorded using silicon probes (Ca. No. P64-7), revealing electrophysiological activity that closely resembles that of the actual human heart.

  • Clinical and Translational Updates

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재고상품 출발날짜: 영업일 기준 4일

가격(KRW) : 135,000

가격(KRW) : 10,080,000

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Datasheet & Documentation

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DMF (Drug Master File)

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