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CD47

요약

Name:Cluster of differentiation 47
Target Synonym:MER6,CD47,Leukocyte surface antigen CD47,CD47 Molecule,Antigenic Surface Determinant Protein OA3,CD47 Antigen (Rh-Related Antigen, Integrin-Associated Signal Transducer),Antigen Identified By Monoclonal Antibody 1D8,Integrin Associated Protein,Rh-Related Antigen,CD47 Glycoprotein,IAP,Integrin-Associated Signal Transducer,Protein MER6,OA3,CD47 Antigen,Integrin-Associated Protein
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:36
Lastest Research Phase:Phase 3 Clinical

라이센싱

항목 적응증 연구 단계 합작 수요
BDA202202 Hematologic tumors, solid tumors License-out or co-development License-out or co-development

제품 리스트 비교 또는 구매

제품번호 제품 설명 구조 순도 특징
EP-138 Human CD47[Biotinylated] : SIRP alpha Inhibitor Screening ELISA Kit
MBS-K023 Human Human CD47-coupled Magnetic Beads
CD7-H82A3 Human Biotinylated Human CD47 Protein, Mouse IgG2a Fc,Avitag™ (MALS verified)
CD7-H82A3-structure
CD7-H82A3-sds
CD7-HF2H3 Human FITC-Labeled Human CD47 Protein, His Tag
CD7-HF2H3-structure
CD7-HF2H3-sds
CD7-H82F8 Human Biotinylated Human CD47 Protein, Fc (L234A, L235A, P329G),Avitag™
CD7-H82F8-structure
CD7-H82F8-sds
CD7-M82E4 Mouse Biotinylated Mouse CD47 Protein, His,Avitag™
CD7-M82E4-structure
CD7-M82E4-sds
CD7-C52H5 Canine Canine CD47 Protein, His Tag
CD7-C52H5-structure
CD7-C52H5-sds
EP-102 Human CD47: SIRP alpha [Biotinylated] Inhibitor Screening ELISA Assay Pair
CD7-H522a Human Human CD47 Protein, His Tag, low endotoxin
CD7-H522a-structure
CD7-H522a-sds
CD7-H5251 Human Human CD47 Protein, Llama IgG2b Fc Tag, low endotoxin
CD7-H5251-structure
CD7-H5251-sds
CD7-M525a Mouse Mouse CD47 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-M525a-structure
CD7-M525a-sds
CD7-M522b Mouse Mouse CD47 Protein, His Tag
CD7-M522b-structure
CD7-M522b-sds
CD7-C52H1 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque CD47 Protein, His Tag
CD7-C52H1-structure
CD7-C52H1-sds
CD7-HA2E9 Human Unconjugated Human CD47 Protein, His,Avitag™
CD7-HA2E9-structure
CD7-HA2E9-sds
CD7-H82E9 Human Biotinylated Human CD47 Protein, His,Avitag™
CD7-H82E9-structure
CD7-H82E9-sds
CD7-R5257 Rabbit Rabbit CD47 Protein, Fc Tag
CD7-R5257-structure
CD7-R5257-sds
CD7-R5256 Rat Rat CD47 Protein, Fc Tag
CD7-R5256-structure
CD7-R5256-sds
CD7-H52A5 Human Human CD47 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-H52A5-structure
CD7-H52A5-sds
CD7-C5252 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque CD47 Protein, Fc Tag
CD7-C5252-structure
CD7-C5252-sds
CD7-M5251 Mouse Mouse CD47 Protein, Fc Tag
CD7-M5251-structure
CD7-M5251-sds
CD7-H82F6 Human Biotinylated Human CD47 Protein, Fc,Avitag™
CD7-H82F6-structure
CD7-H82F6-sds
CD7-H5227 Human Human CD47 Protein, His Tag (MALS verified)
CD7-H5227-structure
CD7-H5227-sds
CD7-H5256 Human Human CD47 Protein, Fc Tag (MALS verified)
CD7-H5256-structure
CD7-H5256-sds

일부의 생물활성 데이터

CD7-H82E9-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

FACS assay shows that Biotinylated Human CD47, His,Avitag (Cat. No. CD7-H82E9) can bind to ACHN cell expressing human SIRP-a. The concentration of CD47 used is 10 μg/mL (Routinely tested).

CD7-H82E9-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

FACS analysis shows that the binding of Human CD47 to ACHN expressing SIRP-a was inhibited by increasing concentration of neutralizing SIRP-a antibody. The concentration of Human CD47 used is 20 μg/mL. IC50=9.334 μg/mL

CD7-C52H1-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-CD47 Mab (Human IgG4) captured on CM5 chip via anti-human IgG Fc antibodies surface, can bind Cynomolgus/Rhesus macaque CD47, His Tag (Cat. No. CD7-C52H1) with an affinity constant of 1.8 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

CD7-H5227-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-Human CD47 MAb (Human IgG4) captured on CM5 chip via Anti-Human IgG Fc antibodies surface, can bind Human CD47, His Tag (Cat. No. CD7-H5227) with an affinity constant of 1.66 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

사용자 리뷰

Synonym Name

CD47,MER6,IAP,OA3

Background

Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.

Clinical and Translational Updates

Related Molecule

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
SG404 SG-404; SG404 Phase 1 Clinical Hangzhou Sumgen Biotechnology Co Ltd Neoplasms Details
Anti-CD47 monoclonal antibody (Biocad) Phase 1 Clinical Biocad Neoplasms Details
IMM2505 IMM2505 Phase 1 Clinical Shenghe (China) Biopharmaceutical Co Ltd Solid tumours Details
JMT-601 JMT-601 Phase 1 Clinical Shanghai Jinmante Biological Technology Co Ltd Lymphoma, Non-Hodgkin Details
SG12473 SG12473; SG-12473 Phase 1 Clinical Hangzhou Sumgen Biotechnology Co Ltd Hematologic Neoplasms; Solid tumours; Neoplasms Details
Recombinant humanized anti-CD-47 monoclonal antibody (Shandong New Time Pharmaceutical) Phase 1 Clinical Shandong New Time Pharmaceutical Co Ltd Lymphoma Details
Letaplimab IBI-188 Phase 3 Clinical Innovent Biologics(Suzhou) Co Ltd Neoplasms; Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
Kintuzumab(GenSci) Phase 1 Clinical Changchun Genescience Pharmaceutical Co Ltd Hematologic Neoplasms; Solid tumours; Lymphoma Details
TQB-2928 TQB-2928 Phase 1 Clinical Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd Neoplasms Details
CPO-107 Conjupro Biotherapeutics Inc Details
PF-07257876 Details
Monoclonal Antibody (Mab) sB24M Phase 1 Clinical Pyoderma Gangrenosum Details
DSP-107 DSP-107; KAHR-107 Kahr Medical Details
AL-008 AL-008; IBI-397 Phase 1 Clinical Alector Neoplasms Details
ZL-1201 ZL-1201 Phase 1 Clinical Zai Lab (Shanghai) Co Ltd Solid tumours; Hematologic Neoplasms Details
Simridarlimab IBI-322; IBI322 Phase 1 Clinical Innovent Biologics(Suzhou) Co Ltd Hematologic Neoplasms; Solid tumours; Neoplasms; Lymphoma, T-Cell; Leukemia, Myeloid, Acute Details
IMM-0306 IMM-0306 Phase 1 Clinical Lymphoma, B-Cell Details
Urabrelimab SRF-231 Surface Oncology Details
TG-1801 NI-1701; TG-1801 Novimmune Details
Recombinant humanized monoclonal antibody MIL95(Mabworks/Connaught Biomedical Technology) MIL-95; CM-312 Phase 1 Clinical Beijing Mabworks Biotech Co Ltd, Keymed Biosciences Co Ltd Solid tumours; Lymphoma; Leukemia, Myeloid, Acute Details
IMM 01(ImmuneOnco Biopharma) IMM01; IMM 01 Phase 2 Clinical Leukemia, Promyelocytic, Acute; Solid tumours; Myelodysplastic Syndromes; Hodgkin Disease; Multiple Myeloma; Lymphoma, Extranodal NK-T-Cell; Lymphoma; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin Details
Ligufalimab AK-117 Phase 2 Clinical Zhongshan Akeso Biopharma Co Ltd Solid tumours; Squamous Cell Carcinoma of Head and Neck; Neoplasms; Triple Negative Breast Neoplasms; Myelodysplastic Syndromes; Breast Neoplasms; Lymphoma; Leukemia, Myeloid, Acute Details
STI-6643 STI-6643 Phase 1 Clinical Sorrento Therapeutics Inc Solid tumours; Neoplasms Details
ISB-1442 ISB 1442; ISB-1442 Phase 2 Clinical Ichnos Sciences Sa Multiple Myeloma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute Details
RRx-001 ABDNAZ; RRx-001 Phase 3 Clinical Epicentre Biotechnologies Llc Brain Neoplasms; Stomatitis; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Brain metastases; Carcinoma, Small Cell; Lymphoma; Colorectal Neoplasms; Cholangiocarcinoma; Solid tumours; Neuroendocrine Tumors; Central Nervous System Neoplasms; Oligodendroglioma; Carcinoma, Ovarian Epithelial; Neoplasms; Small Cell Lung Carcinoma; Glioblastoma Details
HX-009 HX-009 Phase 2 Clinical Hanx Biopharmaceutical Co Ltd, Wuhan Hanxiong Biotechnology Co Ltd Solid tumours; Liver Neoplasms; Stomach Neoplasms; Lymphoma Details
AO-176 AO-176; Ti-104; Ti-108; Ti-176 Phase 2 Clinical Arch Oncology Solid tumours; Multiple Myeloma Details
CC-90002 INBRX-103; CC-90002 Phase 1 Clinical Inhibrx Hematologic Neoplasms; Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
Lemzoparlimab TJ-011133; TJC-4; ABBV-IMAB-TJC4; TJ-1133 Phase 2 Clinical I-Mab Biopharma Co Ltd, Abbvie Inc Solid tumours; Hematologic Neoplasms; Myelodysplastic Syndromes; Multiple Myeloma; Leukemia, Myeloid, Acute; Lymphoma Details
6MW-3211 6MW3211; 6MW-3211 Phase 2 Clinical Mabwell (Shanghai) Bioscience Co Ltd Carcinoma, Renal Cell; Neoplasms; Myelodysplastic Syndromes; Lymphoma; Lung Neoplasms; Leukemia, Myeloid, Acute Details
SHS-009 SHS-009; SH009; SH-009 Phase 1 Clinical Nanjing Sanhome Pharmaceutical Co Ltd Neoplasms Details
HMPL-A83 HMPL-A-83; HMPL-A83 Phase 1 Clinical Hutchison Huangpu Medicine (Shanghai) Co Ltd Solid tumours; Hematologic Neoplasms; Neoplasms Details
BAT-7104 BAT-7104 Phase 1 Clinical Bio-Thera Solutions Ltd Solid tumours; Neoplasms Details
IMM-2902 IMM-2902 Phase 1 Clinical ImmuneOnco Biopharmaceuticals (Shanghai) Co Ltd Solid tumours Details
BC-007 (Dragonboat Biopharmaceutical) BC-007 Phase 1 Clinical Dragonboat Biopharmaceutical Neoplasms Details
TTI-622 TTI-622 Phase 2 Clinical Trillium Therapeutics Inc Ovarian Neoplasms; Lymphoma, Large B-Cell, Diffuse; Carcinoma, Ovarian Epithelial; Multiple Myeloma; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Leukemia, Myeloid, Acute; Lymphoma Details
Ontorpacept TTI-621 Phase 2 Clinical The Hospital For Sick Children, University Health Network Leiomyosarcoma; Hematologic Neoplasms; Solid tumours; Papillomavirus Infections; Multiple Myeloma; Sarcoma; Breast Neoplasms; Carcinoma, Squamous Cell; Melanoma; Mycosis Fungoides Details
Evorpacept ALX148; ALX-148 Phase 3 Clinical Alexo Therapeutics Ovarian Neoplasms; Head and Neck Neoplasms; Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Squamous Cell Carcinoma of Head and Neck; Myelodysplastic Syndromes; Neoplasms; Colorectal Neoplasms; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute; Adenocarcinoma; Neoplasm Metastasis Details
PT-886 PT-886 Phase 1 Clinical Phanes Therapeutics Inc Stomach Neoplasms; Pancreatic Neoplasms Details
IMC-002 IMC-002; 3D-197; 3D197 Phase 1 Clinical Immuneoncia Therapeutics Solid tumours; Hematologic Neoplasms; Ovarian Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Neoplasms; Pancreatic Neoplasms; Lymphoma; Neoplasm Metastasis; Adenocarcinoma Details
SL-172154 SL-172154 Phase 1 Clinical Shattuck Labs Inc Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Myelodysplastic Syndromes; Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Squamous Cell Details
SG-2501 SG-2501 Phase 1 Clinical Hangzhou Sumgen Biotechnology Co Ltd Hematologic Neoplasms; Lymphoma Details
Magrolimab 5-F-9; Hu5F9-G4; ONO-7913 Phase 3 Clinical Stanford University Solid tumours; Hematologic Neoplasms; Leukemia, Myeloid; Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Myelodysplastic Syndromes; Carcinoma, Transitional Cell; Hodgkin Disease; Multiple Myeloma; Urinary Bladder Neoplasms; Brain Neoplasms; Colorectal Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin Details

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