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Your Position: 홈 > Protein > TDP-43 > TD3-H5145

Human TDP-43 Protein, His Tag

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INTRODUCTION
QC & Assay Protocol
Citation & Background
  • Synonym
    TAR DNA-binding protein 43
  • Source
    Human TDP-43, His Tag(TD3-H5145) is expressed from E. coli cells. It contains AA Met 1 - Met 414 (Accession # Q13148-1).
    Predicted N-terminus: Met
    Request for sequence
  • Molecular Characterization
    TDP-43 Structure

    This protein carries a polyhistidine tag at the N-terminus

    The protein has a calculated MW of 46.8 kDa. The protein migrates as 54-56 kDa under reducing (R) condition (SDS-PAGE).

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Supplied as 0.2 μm filtered solution in 50 mM HEPES, 500 mM NaCl, 0.4 M Arginine, pH8.0 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 12 months under sterile conditions.
SDS-PAGE
TDP-43 SDS-PAGE

Human TDP-43, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity-ELISA
TDP-43 ELISA

Immobilized Human TDP-43, His Tag (Cat. No. TD3-H5145) at 1 μg/mL (100 μL/well) can bind Anti-TDP43 Antibody with a linear range of 0.2-3 ng/mL (QC tested).

Protocol
  • Background
    TDP-43, the transactive response (TAR)-D binding Protein with a molecular weight of 43 KDa is encoded by TARDBP gene that located at the chromosome 1. It is a R/D binding protein that structurally resembles a typical hnRNP protein family member. involved in transcriptional regulation and R processing. It is linked to sporadic and familial amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 is predominantly nuclear, but it translocates to the cytoplasm under pathological conditions. Cytoplasmic accumulation, phosphorylation, ubiquitination and truncation of TDP-43 are the main hallmarks of TDP-43 proteinopathies.
  • Clinical and Translational Updates

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