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TDP-43

요약

Name:TAR DNA binding protein 43
Target Synonym:TAR DNA-binding protein 43,TARDBP,TAR DNA Binding Protein,TDP43,TAR DNA-Binding Protein-43,ALS10
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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TD3-H5145 Human Human TDP-43 Protein, His Tag
TD3-H5145-structure

Synonym Name

TAR DNA-binding protein 43

Background

TDP-43, the transactive response (TAR)-DNA binding Protein with a molecular weight of 43 KDa is encoded by TARDBP gene that located at the chromosome 1. It is a RNA/DNA binding protein that structurally resembles a typical hnRNP protein family member.  involved in transcriptional regulation and RNA processing. It is linked to sporadic and familial amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 is predominantly nuclear, but it translocates to the cytoplasm under pathological conditions. Cytoplasmic accumulation, phosphorylation, ubiquitination and truncation of TDP-43 are the main hallmarks of TDP-43 proteinopathies.

Clinical and Translational Updates

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