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Your Position: > CAR-T > FMC63 > FM3-FY45P1

FITC-Labeled Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) (HEK293)

  • 출처
    FITC-Labeled Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 is expressed from human HEK293 cells. It is the FITC labeled form of Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Cat. No. FM3-Y45P1).
  • 아이소타입
    Mouse IgG1/kappa
  • 특이성
    Specifically recognizes the antigen-recognition domain of FMC63 derived CARs.
  • Labeling
    The primary amines in the side chains of lysine residues and the N-terminus of the protein are conjugated with FITC using standard chemical labeling method. The residual FITC is removed by molecular sieve treatment during purification process.
  • FITC:Protein Ratio
    The FITC to protein molar ratio is 1-3.
  • 어플리케이션
    Flow Cytometry (Evaluation of Anti-CD19 (FMC63 scFv) CAR Expression).
    *The 아이소타입 control (Cat. No. DNP-FM1A1) is sold separately and you can follow this link for product information.
  • 레시피

    Lyophilized from 0.22 μm filtered solution in PBS, 0.5% BSA, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • 재구성

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 보관

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;

    2. -70°C for 3 months under sterile conditions after reconstitution.

Bioactivity-FACS
FACS assay shows that recombinant Biotinylated FACS

2e5 of anti-CD19 CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of FITC-Labeled Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Cat. No. FM3-FY45P1) and 아이소타입 control antibody respectively. FITC signal was used to evaluate the binding activity (QC tested).

  • 백그라운드
    FMC63 is an IgG2a mouse monoclonal antibody specific for CD19, which is a target for the immunotherapy of B lineage leukaemias and lymphomas. FMC63 scFv is the most commonly used ectodomain component of CD19-specific CARs. So far, most of reported CART19 trials contain the anti-CD19 scFv derived from FMC63, including the two FDA-approved CARs Kymriah and Yescarta.
  • Clinical and Translational Updates

      

  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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ETD of in-stock products: 4 business days

가격(KRW) : 478,500

가격(KRW) : 2,970,000

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