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FMC63

제품 리스트 비교 또는 구매

제품번호 제품 설명 구조 순도 특징
CD9-BV4324b Mouse Biotinylated Anti-CD19 scFv, Fc, Avitag™ (FMC63) (MALS verified)
CD9-BV4324b-sds
RAB-P001 Rabbit Rabbit Anti-Mouse FMC63 scFv PAbs ELISA Kit (For ADA Assay)
FM3-PY54A2 Mouse PE-Labeled Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) (Site-specific conjugation) DMF Filed (0.03% Proclin)
CD9-M52Hb Mouse FMC63 scFv, His Tag (SPR verified)
CD9-M52Hb-sds
FM3-AY54P1 Mouse APC-Labeled Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) (Site-specific conjugation)
FM3-FY45P1 Mouse FITC-Labeled Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) (HEK293)
FM3-Y45A1 Mouse Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) (Carrier-free) (recommended for ADA assay) DMF Filed
FM3-Y45A1-sds
FM3-S93 Rabbit Rabbit Anti-Mouse FMC63 scFv Polyclonal Antibody (recommended for ADA assay) (MALS verified)
FM3-S93-sds
FM3-BY54 Mouse Biotinylated Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1, Avitag™ (Y45) DMF Filed
FM3-HPY53 Mouse PE-Labeled Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) (Site-specific conjugation) DMF Filed (Preservative free)
FM3-Y45P1 Mouse Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) (HEK293) DMF Filed
FM3-FY45 Mouse FITC-Labeled Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) DMF Filed
FM3-Y45 Mouse Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) DMF Filed

일부의 생물활성 데이터

FM3-PY54A2-Cell-based assay
 FMC63 FACS

5e5 of anti-CD19 CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Monoclonal Anti FMC63 scFv Antibody, Mouse IgG1 (Cat. No. FM3-PY54A2) and isotype control antibody respectively. PE signal was used to evaluate the binding activity (QC tested).

FM3-PY54A2-Cell-based assay
 FMC63 FACS

Binding activity of the PE-Labeled Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 before and after adding 0.03% Proclin was evaluated in the above FACS analysis. The result shows that 0.03% Proclin (Cat. No. FM3-PY54A2) and Preservative free (Cat. No. FM3-HPY53) PE-Labeled Monoclonal Anti-FMC63 scFv Antibody have the same binding activity against anti-CD19 CAR-293 cells.

CD9-M52Hb-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human CD19 (20-291), Fc Tag (Cat. No. CD9-H5251) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind FMC63 scFv, His Tag (Cat. No. CD9-M52Hb) with an affinity constant of 0.668 nM as determined in a SPR assay (Biacore 8K) (QC tested).

FM3-Y45A1-SPR
Human_FcRn_Heterodimer_Protein_SPR

Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) (Carrier-free)(Cat. No. FM3-Y45A1) captured on CM5 chip via anti-mouse antibodies surface can bind FMC63 scFv with an affinity constant of 1.08 nM as determined in a SPR assay (Routinely tested).

사용자 리뷰

Synonym Name

Anti-FMC63 Ab & Anti-FMC63 scFv Antibody

Background

FMC63 is an IgG2a mouse monoclonal antibody specific for CD19, which is a target for the immunotherapy of B lineage leukaemias and lymphomas. FMC63 scFv is the most commonly used ectodomain component of CD19-specific CARs. So far, most of reported CART19 trials contain the anti-CD19 scFv derived from FMC63, including the two FDA-approved CARs Kymriah and Yescarta.

Clinical and Translational Updates

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