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Your Position: > Protein > Mesothelin > MSN-R52H4

Rat Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)

  • Synonym
    MSLN,Mesothelin,MPF
  • Source
    Rat Mesothelin (298-600), His Tag(MSN-R52H4) is expressed from human 293 cells (HEK293). It contains AA Asp 298 - Ser 600 (Accession # XP_032768340.1).
    Predicted N-terminus: Asp 298
  • Molecular Characterization
    Mesothelin Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 35.9 kDa. The protein migrates as 43-48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Mesothelin SDS-PAGE

Rat Mesothelin (298-600), His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Mesothelin MALS images

The purity of Rat Mesothelin (298-600), His Tag (Cat. No. MSN-R52H4) is more than 90% and the molecular weight of this protein is around 34-52 kDa verified by SEC-MALS.

Bioactivity-ELISA
 Mesothelin ELISA

Immobilized Rat Mesothelin (298-600), His Tag (Cat. No. MSN-R52H4) at 2 μg/mL (100 μL/well) can bind Monoclonal Anti-Human MSLN Antibody, Human IgG1 with a linear range of 8-125 ng/mL (QC tested).

 Mesothelin ELISA

Immobilized Rat Mesothelin (298-600), His Tag (Cat. No. MSN-R52H4) at 2 μg/mL (100 μL/well) can bind Biotinylated Human CA125, Fc,Avitag (Cat. No. CA5-H82F4) with a linear range of 0.5-16 ng/mL (Routinely tested).

Bioactivity-BLI
 Mesothelin BLI

Loaded Monoclonal Anti-Human MSLN Antibody, Human IgG1 on Protein A Biosensor, can bind Rat Mesothelin (298-600), His Tag (Cat. No. MSN-R52H4) with an affinity constant of 301 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

  • Background
    Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.
  • Clinical and Translational Updates

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