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Mesothelin

요약

Name:Mesothelin
Target Synonym:Pre-pro-megakaryocyte-potentiating factor,Mesothelin,MSLN,CAK1 Antigen,MPF,Soluble MPF Mesothelin Related Protein,Megakaryocyte Potentiating Factor,SMRP,CAK1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:18
Lastest Research Phase:Phase 2 Clinical

제품 리스트 비교 또는 구매

제품번호 제품 설명 구조 순도 특징
MSN-HA2H8 Human Alexa Fluor 555-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HA2H8-structure
MSN-HA2H7 Human APC-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag (Site-specific conjugation)
MSN-HA2H7-structure
MSN-HA2H6 Human APC-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HA2H6-structure
MSN-HP2H8 Human PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HP2H8-structure
MSN-HF2H3 Human FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HF2H3-structure
MSN-HF2H3-sds
MSN-H82E7 Human Biotinylated Human Mesothelin / MSLN (296-600) Protein, His,Avitag™ (MALS verified)
MSN-H82E7-structure
MSN-H82E7-sds
MSN-R52H4 Rat Rat Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)
MSN-R52H4-structure
MSN-R52H4-sds
MBS-K024 Human Human Mesothelin-coupled Magnetic Beads
MSN-M82E7 Mouse Biotinylated Mouse Mesothelin / MSLN Protein, His,Avitag™
MSN-M82E7-structure
MSN-M82E7-sds
MSN-HP2H5 Human PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag (Site-specific conjugation) DMF Filed
MSN-C52H6 Cynomolgus Cynomolgus Mesothelin / MSLN (296-580) Protein, His Tag (MALS verified)
MSN-C52H6-structure
MSN-C52H6-sds
MSN-M52H3 Mouse Mouse Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)
MSN-M52H3-structure
MSN-M52H3-sds
MSN-HF25x Human FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-HF25x-structure
MSN-HF25x-sds
MSN-HR2P4 Human RFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HR2P4-structure
MSN-HR2P4-sds
MSN-HG2P4 Human GFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HG2P4-structure
MSN-HG2P4-sds
MSN-HF223 Human FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HF223-structure
MSN-HF223-sds
MSN-HF253 Human FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-HF253-structure
MSN-HF253-sds
MSN-H82F6 Human Biotinylated Human Mesothelin / MSLN (296-580) Protein, Fc,Avitag™
MSN-H82F6-structure
MSN-H82F6-sds
MSN-H522a Human Human Mesothelin / MSLN (296-580) Protein, His Tag, low endotoxin (MALS verified)
MSN-H522a-structure
MSN-H522a-sds
MSN-H5253 Human Human Mesothelin / MSLN (296-580) Protein, Fc Tag (MALS verified)
MSN-H5253-structure
MSN-H5253-sds
MSN-H82E9 Human Biotinylated Human Mesothelin / MSLN (296-580) Protein, His,Avitag™ (MALS verified) DMF Filed
MSN-H82E9-structure
MSN-H82E9-sds
MSN-H826x Human Biotinylated Human Mesothelin / MSLN (296-580), Fc Tag, ultra sensitivity (primary amine labeling) (MALS verified)
MSN-H826x-structure
MSN-H826x-sds
MSN-H8223 Human Biotinylated Human Mesothelin / MSLN (296-580) Protein, His Tag, ultra sensitivity (primary amine labeling)
MSN-H8223-structure
MSN-H8223-sds
MSN-H526x Human Human Mesothelin / MSLN (296-580) Protein, Fc Tag (MALS verified)
MSN-H526x-structure
MSN-H526x-sds
MSN-H5222 Human Human Mesothelin / MSLN (37-286) Protein, His Tag
MSN-H5222-structure
MSN-H5222-sds

일부의 생물활성 데이터

MSN-HA2H8-Cell-based assay
Evaluation of CAR expression

5e5 of anti-MSLN CAR-293 cells were stained with 100 μL of 3 μg/mL of AF555-Labeled Human Mesothelin (296-580), His Tag (Cat. No.MSN-HA2H8) and negative control protein respectively (Fig. C and B), and non-transfected 293 cells were used as a control (Fig. A). AF555 signal was used to evaluate the binding activity (QC tested).

MSN-HR2P4-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-human MSLN mAb (chimeric mouse-human IgG1) captured on CM5 chip via Anti-human IgG Fc antibodies surface, can bind RFP Fusion Human Mesothelin (296-580), His Tag (Cat. No. MSN-HR2P4) with an affinity constant of 0.304 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

MSN-HG2P4-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-human MSLN MAb (chimeric mouse-human IgG1) captured on CM5 chip via Anti-human IgG Fc antibodies surface, can bind GFP Fusion Human Mesothelin (296-580), His Tag (Cat. No. MSN-HG2P4) with an affinity constant of 0.542 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Synonym Name

MSLN,Mesothelin,MPF

Background

Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

Clinical and Translational Updates

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
RNA-Meso-CIR-T RNA-Meso-CIR-T Phase 1 Clinical Novartis Pharma Ag, University Of Pennsylvania Mesothelioma Details
Anti-mesothelin CAR-T (Pregene) Clinical Pregene (Shenzhen) Biotechnology Co Ltd Hydrothorax Details
Anti-CTLA-4 and PD-1 CAR-T cell therapy (Shanghai Cell Therapy Research Institute) Phase 2 Clinical Shanghai Cell Therapy Research Institute Neoplasms Details
KD-021 KD-021 Phase 1 Clinical Neoplasms Details
PM-3006 PM-3006 Phase 1 Clinical Biotheus Inc Details
LCAR-M23 Nanjing Legend Biotechnology Co Ltd Details
Inezetamab AMG-994 Amgen Inc Details
Autologous Mesothelin-specific TCR-T Cell Therapy (Lonza Walkersville) Phase 1 Clinical Pancreatic Neoplasms Details
Anti-MESO CAR-T cell(Ruijin Hospital) Ruijin Hospital, Shanghai Jiaotong University School Of Medicine Neoplasms Details
BMS-986148 BMS-986148 Bristol-Myers Squibb Company Details
anti-mesothelin thorium-227 labeled antibody chelator conjugate BAY-2287411 Bayer AG Details
RG-7600 RG-7600; DMOT-4039A Genentech Inc Details
anti-MESO CAR-T cells (Zhejiang University) Zhejiang University Details
ABBV-428 ABBV-428; ABBV428 Abbvie Inc Details
Gavocabtagene autoleucel TC-210 Tcr2 Therapeutics Details
iCasp9M28z iCasp9M28z Memorial Sloan Kettering Cancer Center Details
Amatuximab MORAb-009; MORAB-009-006 National Cancer Institute Details
CART-meso CART-meso Novartis Pharma Ag, University Of Pennsylvania Details
RC-88 RC-88 Phase 2 Clinical RemeGen Co Ltd Solid tumours Details
Anti-mesothelin CAR T cell therapy (Shanghai GeneChem) Shanghai Genechem Co Ltd Details
Anti-mesothelin CAR-NK cell therapy(Guojianchengnuo) ALF-101 Phase 1 Clinical Guojianchengnuo Biotechnology (Beijing) Co Ltd Carcinoma, Ovarian Epithelial Details
Anetumab ravtansine BAY-94-9343; BAY-94-9343-SPDB-DM4; Anti-mesothelin antibody-drug conjugate BAY 94-9343 Phase 1 Clinical Bayer AG, Morphosys Ovarian Neoplasms; Neoplasms; Pancreatic Neoplasms; Mesothelioma Details

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