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Your Position: 홈 > Protein > 4-1BB > 41B-R52H3

Rat 4-1BB / TNFRSF9 Protein, His Tag (MALS verified)

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소개
QC & Assay Protocol
Citation & 백그라운드
  • 동의어
    TNFRSF9,4-1BB,CD137,CDw137,ILA
  • 출처
    Rat 4-1BB, His Tag (41B-R52H3) is expressed from human 293 cells (HEK293). It contains AA Thr 24 - Gln 187 (Accession # Q4W8J3-1).
    Predicted N-terminus: Thr 24
    Request for sequence
  • 분자 표징
    Online(Thr 24 - Gln 187) Q4W8J3-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 19.5 kDa. The protein migrates as 28-38 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 내독소
    Less than 1.0 EU per μg by the LAL method.
  • 순도

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • 레시피

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • 재구성

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 보관

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Rat 4-1BB, His Tag (Cat. No. 41B-R52H3) SDS-PAGE gel

Rat 4-1BB, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

SEC-MALS
Rat 4-1BB, His Tag (Cat. No. ) MALS images

The purity of Rat 4-1BB, His Tag(Cat. No. 41B-R52H3) is more than 90% and the molecular weight of this protein is around 30-40 kDa verified by SEC-MALS.

Report
Bioactivity-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Mouse 4-1BB Ligand, Fc Tag (Cat. No. 41L-M5257) on Protein A Biosensor, can bind Rat 4-1BB, His Tag (Cat. No. 41B-R52H3) with an affinity constant of 74.3 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
  • 백그라운드
    4-1BB is also known as CD137, tumor necrosis factor receptor superfamily member 9 (TNFRSF9), induced by lymphocyte activation (ILA), is a co-stimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice. CD137 can enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, 4-1BB/4-1BBL co-stimulatory pathway has been shown to augment secondary CTL responses to several viruses, and meanwhile augment anti-tumor immunity. 4-1BB thus is a promising candidate for immunotherapy of human cancer. CD137 has been shown to interact with TRAF2.
  • Clinical and Translational Updates
      

  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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