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Anti-BCMA Neutralizing Antibody, Mouse IgG1 (recommended for neutralizing assay)

  • Description
    Anti-BCMA Neutralizing Antibody, Mouse IgG1 (BCA-M43) recognizes the Human BCMA Protein extracellular and can inhibit the interaction between BCMA and BAFF/APRIL. It is expressed from human 293 cells (HEK293).
  • Isotype
    Mouse IgG1/kappa
  • Specificity
    The product is specific for Human BCMA Protein extracellular, and can inhibit the interaction between BCAM and BAFF (IC50= 4.877 μg/mL), BCAM and APRIL (IC50= 4.624 μg/mL). It also has cross reactivity with Cynomolgus & Mouse BCMA protein.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 years under sterile conditions after reconstitution.
SDS-PAGE
Anti-BCMA Neutralizing Antibody, Mouse IgG1 (Cat. No. BCA-M43) SDS-PAGE gel

Anti-BCMA Neutralizing Antibody, Mouse IgG1 on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Bioactivity-ELISA
Anti-BCMA Neutralizing Antibody, Mouse IgG1Anti-BCMA Neutralizing Antibody, Mouse IgG1 (Cat. No. BCA-M43) ELISA bioactivity

Immobilized Anti-BCMA Neutralizing Antibody, Mouse IgG1 (Cat. No. BCA-M43) at 0.2 μg/mL (100μL/well) can bind Human BCMA Protein, His Tag (HPLC-verified) (Cat. No. BCA-H522y) with a linear range of 0.2-6 ng/mL (QC tested).

Anti-BCMA Neutralizing Antibody, Mouse IgG1Anti-BCMA Neutralizing Antibody, Mouse IgG1 (Cat. No. BCA-M43) ELISA bioactivity

Immobilized Human BCMA, His Tag (Cat. No. BCA-H522y) at 2 μg/mL (100 μL/well) can bind pre-mixed increasing concentrations of Anti-BCMA Neutralizing Antibody, Mouse IgG1 (Clone: AM43, Cat. No. BCA-M43) and 0.01 μg/mL (100 μL/well) Biotinylated Human BAFF, His,Avitag (Cat. No. BAF-H82Q2) with a half maximal inhibitory concentration (IC50) of 4.877 μg/mL (Routinely tested).

Anti-BCMA Neutralizing Antibody, Mouse IgG1Anti-BCMA Neutralizing Antibody, Mouse IgG1 (Cat. No. BCA-M43) ELISA bioactivity

Immobilized Human BCMA, His Tag (Cat. No. BCA-H522y) at 2 μg/mL (100 μL/well) can bind pre-mixed increasing concentrations of Anti-BCMA Neutralizing Antibody, Mouse IgG1 (Clone: AM43, Cat. No. BCA-M43) and 0.05 μg/mL (100 μL/well) Biotinylated Human APRIL, Fc,Avitag (Cat. No. APL-H82F5) with a half maximal inhibitory concentration (IC50) of 4.624 μg/mL (Routinely tested).

Bioactivity-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-BCMA Neutralizing Antibody, Mouse IgG1 (Clone: AM43, Cat. No. BCA-M43) captured on CM5 chip via anti-mouse antibodies surface can bind Human BCMA, His Tag (Cat. No. BCA-H522y) with an affinity constant of 0.388 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

  • Background
    Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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ETD of in-stock products: 4 business days

가격(KRW) : 450,000

가격(KRW) : 3,270,000

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