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IgG3 Fc

요약

Name:Immunoglobulin G
Target Synonym:Immunoglobulin G
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

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제품번호 제품 설명 구조 순도 특징
IG3-M5214 Mouse Mouse IgG3 Fc Protein, Tag Free (MALS verified)
IG3-M5214-structure
IG3-M5214-sds
IG3-H5200 Human Human IgG3 Fc Protein, Tag Free (MALS & SPR verified)
IG3-H5200-structure
IG3-H5200-sds

일부의 생물활성 데이터

IG3-H5200-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human FCGRT&B2M Heterodimer Protein, His Tag (Cat. No. FCN-H52W7) captured on CM5 Chip via anti-His antibody can bind Human IgG3 Fc, Tag Free (Cat. No. IG3-H5200) with an affinity constant of 2.82 μM as determined in SPR assay (Biacore 8K) (QC tested).

IG3-M5214-MALS-HPLC
Mouse IgG3 Fc Protein, Tag Free (Cat. No. ) MALS images

The purity of Mouse IgG3 Fc Protein, Tag Free (Cat. No. IG3-M5214) is more than 90% and the molecular weight of this protein is around 60-70 kDa verified by SEC-MALS.

Bioactivity-ELISA
Mouse IgG3 Fc Protein, Tag FreeMouse IgG3 Fc Protein, Tag Free (Cat. No. IG3-M5214) ELISA bioactivity

Immobilized Mouse IgG3 Fc Protein, Tag Free (Cat. No. IG3-M5214) at 5 μg/mL (100 μL/well) can bind Biotinylated Human CD64, His,Avitag (Cat. No. FCA-H82E8) with a linear range of 0.6-10 ng/mL (QC tested).

Synonym Name

Ig gamma-3 chain C region,IgG, IgG3

Background

Immunoglobulin G3 (IgG3) is a member of many immunoglobulin G developed and secreted by effective B cells. In wake of cutting by pepsin, IgG is divided into two F(ab)s with one antigen binding site and a high conserved Fc segment. The Fc segment bears a highly conserved N-glycosylation site. Ig gamma-3 chain C region (IgG3-Fc / IGHG3) contains two constant regions of IgG3 H chain (CH2, CH3).

Clinical and Translational Updates

공개 약품 정보

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Imlifidase Mac-1 Approved Hansamed Inc Idefirix EU Rejection of renal transplantation Hansa Biopharma Ab 2020-08-25 Rejection of renal transplantation; Purpura, Thrombotic Thrombocytopenic; Kidney Diseases; Rejection of organ transplantation; Guillain-Barre Syndrome; Renal Insufficiency, Chronic; Kidney Failure, Chronic Details

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
Recombinant Tumor Enzyme Specific Interferon α-2b Fc Fusion (Livzon Pharmaceutical Group) A-01 Phase 1 Clinical Livzon Pharmaceutical Group Inc Solid tumours Details
Anti-CD33/anti-FcgammaRI bispecific antibody (UCSD) Phase 1 Clinical University Of California San Diego Leukemia, Myeloid, Acute Details
AT-02 AT-02 Phase 1 Clinical Attralus Inc Immunoglobulin Light-chain Amyloidosis; Amyloidosis Details

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