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PD-L1

요약

Name:Programmed death-ligand 1
Target Synonym:HPD-L1,Programmed Cell Death 1 Ligand 1,PDCD1L1,B7H1,PDL1,Programmed Death Ligand 1,B7-H1,B7-H,B7-H1 Antigen,CD274,B7 homolog 1,PDCD1 ligand 1,PD-L1,PDCD1LG1,CD274 Molecule,CD274 Antigen
Number of Launched Drugs:11
Number of Drugs in Clinical Trials:152
Lastest Research Phase:Approved

제품 리스트 구매

제품번호 제품 설명 구조 순도 특징
PD1-HP2H3 Human PE-Labeled Human PD-L1 / B7-H1 (19-238) Protein, His TagStar Staining
PD1-H5213 Human Human PD-L1 / B7-H1 Protein, Tag Free (MALS verified)
PD1-H5213-structure
PD1-H5213-sds
PD1-C82F3 Cynomolgus / Rhesus macaque Biotinylated Cynomolgus / Rhesus macaque PD-L1 / B7-H1 Protein, Fc,Avitag™ (MALS verified)
PD1-C82F3-structure
PD1-C82F3-sds
PDL-M82E7 Mouse Biotinylated Mouse PD-L1 / B7-H1 Protein, His,Avitag™ (MALS verified)
PDL-M82E7-structure
PDL-M82E7-sds
EP-157 Mouse Mouse PD-L1 : Mouse PD-1 [Biotinylated] Inhibitor Screening ELISA Kit
SCCHO-ATP077M Human CHO/Human PD-L1 Stable Cell Line (Medium Expression) Development Service
SCCHO-ATP077H Human CHO/Human PD-L1 Stable Cell Line (High Expression) Development Service
SCCHO-ATP077L Human CHO/Human PD-L1 Stable Cell Line (Low Expression) Development Service
SCRAJ-STT075 Human Raji/Human PD-L1 Stable Cell Line Development Service
EP-133 Human PD-L1 : PD-1 [Biotinylated] Inhibitor Screening ELISA Kit
PDL-C82E8 Cynomolgus / Rhesus macaque Biotinylated Cynomolgus / Rhesus macaque PD-L1 / B7-H1 Protein, His,Avitag™ (MALS verified)
PDL-C82E8-structure
PDL-C82E8-sds
PDL-C52H4 Canine Canine PD-L1 / B7-H1 Protein, His Tag (MALS verified)
PDL-C52H4-structure
PDL-C52H4-sds
PD1-H82A3 Human Biotinylated Human PD-L1 / B7-H1 Protein, Mouse IgG2a Fc,Avitag™ (MALS verified)
PD1-H82A3-structure
PD1-H82A3-sds
PD1-H52H3 Human Human PD-L1 / B7-H1 (19-134) Protein, His Tag (MALS verified)
PD1-H52H3-structure
PD1-H52H3-sds
PD1-C52H3 Canine Canine PD-L1 / B7-H1 Protein, Fc Tag
PD1-C52H3-structure
PD1-C52H3-sds
PDL-H82E4 Human Biotinylated Human PD-L1 / B7-H1 (19-134) Protein, His,Avitag™ (recommended for biopanning) (MALS verified)
PDL-H82E4-structure
PDL-H82E4-sds
PDL-R52H6 Rabbit Rabbit PD-L1 / B7-H1 Protein, His Tag (MALS verified)
PDL-R52H6-structure
PDL-R52H6-sds
PDL-H5250 Human Human PD-L1 / B7-H1 Protein, Llama IgG2b Fc Tag, low endotoxin (MALS verified)
PDL-H5250-structure
PDL-H5250-sds
PDL-H82F2 Human Biotinylated Human PD-L1 / B7-H1 Protein, Fc,Avitag™ (MALS verified)
PDL-H82F2-structure
PDL-H82F2-sds
PD1-M52A2 Mouse Mouse PD-L1 / B7-H1 Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified)
PD1-M52A2-structure
PD1-M52A2-sds
PD1-H82E5 Human Biotinylated Human PD-L1 / B7-H1 Protein, Avitag™,His Tag (MALS verified)
PD1-H82E5-structure
PD1-H82E5-sds
PD1-M82F5 Mouse Biotinylated Mouse PD-L1 / B7-H1 Protein, Fc,Avitag™ (MALS verified)
PD1-M82F5-structure
PD1-M82F5-sds
PD1-M5220 Mouse Mouse PD-L1 / B7-H1 Protein, His Tag (MALS verified)
PD1-M5220-structure
PD1-M5220-sds
PD1-M5251 Mouse Mouse PD-L1 / B7-H1 Protein, Fc Tag (MALS verified)
PD1-M5251-structure
PD1-M5251-sds
PD1-H52A3 Human Human PD-L1 / B7-H1 Protein, Mouse IgG1 Fc Tag, low endotoxin (MALS verified)
PD1-H52A3-structure
PD1-H52A3-sds
PD1-C52H4 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque PD-L1 / B7-H1 Protein, His Tag (MALS verified)
PD1-C52H4-structure
PD1-C52H4-sds
PD1-C5253 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque PD-L1 / B7-H1 Protein, Fc Tag (MALS verified)
PD1-C5253-structure
PD1-C5253-sds
PD1-H82F3 Human Biotinylated Human PD-L1 / B7-H1 Protein, Fc,Avitag™,His Tag (MALS verified)
PD1-H82F3-structure
PD1-H82F3-sds
PD1-H5282 Human Human PD-L1 / B7-H1 Protein, Twin-Strep Tag (HPLC verified)
PD1-H5282-structure
PD1-H5282-sds
PD1-H5282-hplc
PD1-H5258 Human Human PD-L1 / B7-H1 Protein, Fc Tag (MALS verified)
PD1-H5258-structure
PD1-H5258-sds
PD1-H5229 Human Human PD-L1 / B7-H1 Protein, His Tag (MALS verified)
PD1-H5229-structure
PD1-H5229-sds

일부의 생물활성 데이터

SCCHO-ATP077M-Cell-based assay
 PD-L1 FACS

Expression analysis of human PD-L1 on CHO/ Human PD-L1 Stable Cell Line by FACS.
Cell surface staining using PE-labeled anti-human PD-L1 antibody was performed on CHO/Human PD-L1 Stable Cell Line with different expression levels: CHO/Human PD-L1 Stable Cell Line (Low Expression); CHO/Human PD-L1 Stable Cell Line (Medium Expression); CHO/Human PD-L1 Stable Cell Line (High Expression).

SCCHO-ATP077H-Cell-based assay
 PD-L1 FACS

Expression analysis of human PD-L1 on CHO/ Human PD-L1 Stable Cell Line by FACS.
Cell surface staining using PE-labeled anti-human PD-L1 antibody was performed on CHO/Human PD-L1 Stable Cell Line with different expression levels: CHO/Human PD-L1 Stable Cell Line (Low Expression); CHO/Human PD-L1 Stable Cell Line (Medium Expression); CHO/Human PD-L1 Stable Cell Line (High Expression).

PD1-C82F3-SPR
 PD-L1 SPR

Biotinylated Cynomolgus / Rhesus macaque PD-L1 Protein, Fc,Avitag (Cat. No. PD1-C82F3) captured on Protein A Chip can bind Cynomolgus PD-1 Protein, His Tag (Cat. No. PD1-C52H5) with an affinity constant of 3.09 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

PDL-C82E8-SPR
 PD-L1 SPR

Cynomolgus PD-1, Fc Tag (Cat. No. PD1-C5254) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Biotinylated Cynomolgus / Rhesus macaque PD-L1, His,Avitag (Cat. No. PDL-C82E8) with an affinity constant of 6.59 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

사용자 리뷰

Synonym Name

PD-L1,CD274,B7-H1,PDCD1L1,PDCD1LG1

Background

Programmed cell death 1 ligand 1 (PD-L1) is also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. B7-H1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. PD-L1 is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 involve in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.

Clinical and Translational Updates

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