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Your Position: > Protein > TNFR2 > TN2-H82F3

Biotinylated Human TNFR2 / CD120b / TNFRSF1B Protein, Fc,Avitag™ (MALS verified)

  • Synonym
    TNFRSF1B,CD120b,TBPII,TNF-R-II,TNF-R75,TNFBR,TNFR1B,TNFR2,TNFR80,p75,p75TNFR
  • Source
    Biotinylated Human TNFR2 Protein, Fc,Avitag(TN2-H82F3) is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Asp 257 (Accession # P20333-1).
    Predicted N-terminus: Leu 23
  • Molecular Characterization
    TNFR2 Structure

    This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 53.3 kDa. The protein migrates as 65-80 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Labeling
    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.
  • Protein Ratio
    Passed as determined by the HABA assay / binding ELISA.
  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
TNFR2 SDS-PAGE

Biotinylated Human TNFR2 Protein, Fc,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

SEC-MALS
TNFR2 MALS images

The purity of Biotinylated Human TNFR2 Protein, Fc,Avitag (Cat. No. TN2-H82F3) is more than 90% and the molecular weight of this protein is around 145-170 kDa verified by SEC-MALS.

Bioactivity-ELISA
 TNFR2 ELISA

Immobilized Human TNF-alpha Protein, His Tag (Cat. No. TNA-H5228) at 5 μg/mL (100 μL/well) can bind Biotinylated Human TNFR2 Protein, Fc,Avitag (Cat. No. TN2-H82F3) with a linear range of 0.01-0.313 μg/mL (QC tested).

  • Background
    TNFR2 (tumor necrosis factor receptor superfamily member 1B) is a receptor with high affinity for TNFSF2/TNF-alpha. It has a much lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. TNFR2 mediates most of the metabolic effects of TNF-alpha.
  • Clinical and Translational Updates

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약물 개발 현황

  • Number of Launched Drugs:1 Details
  • Number of Drugs in Clinical Trials:6 Details
  • Latest Research Phase:Approved

Datasheet & Documentation

DMF 신청
DMF (Drug Master File)

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