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Your Position: > Protein > CXCR6 > CX6-H52P3

Human CXCR6 / CD186 Full Length Protein (VLP)

  • Synonym
    BONZO, CD186, CDw186, STRL34, TYMSTR, C-X-C motif chemokine receptor 6
  • Source
    Human CXCR6 Full Length Protein (VLP)(CX6-H52P3) is expressed from human 293 cells (HEK293). It contains AA Ala 2 - Leu 342 (Accession # O00574-1).
    Predicted N-terminus: Asp
  • Molecular Characterization

    The protein has a calculated MW of 82.3 kDa | 56.1 kDa.

    Virus-like particles(VLPs) are formed by self-assembly of envelop/capsid proteins from viruses. Membrane Proteins can be constituted in-situ with VLPs produced from HEK293 cell cultures. These VLPs concentrate conformationally intact membrane proteins directly on the cell surface and produce soluble, high-concentration proteins perfect for immunization and antibody screening.

    The VLPs provide the display of properly folded membrane proteins in their native cellular membrane in a compact size of 100~300 nm diameter (similar to the size of most viruses) making it optimal targets for dendritic cells in vivo and surface attachment for phage display.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Formulation

    The VLPs are highly immunogenic, so the immunization strategy should be optimized (antigen dose, regimen and adjuvant).

    Supplied as 0.2 μm filtered solution in PBS, Arginine, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 12 months under sterile conditions.
*The isotype control of empty/mock VLP (Cat. No. VLP-N5213) is sold separately and not included in protein, you can follow this link for product information.
Bioactivity-ELISA
 CXCR6 ELISA

Immobilized Human CXCR6 Full Length Protein (VLP) (Cat. No. CX6-H52P3) at 5 μg/mL (100 μL/well) can bind Monoclonal Anti-Human CXCR6 antibody, Mouse IgG with a linear range of 1-16 ng/mL (QC tested).

Identity-DLS
 CXCR6 DLS

The mean peak Radius of VLP is 70-95 nm with more than 95% intensity as determined by dynamic light scattering (DLS).

  • Background
    The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the CXC chemokine receptor family. This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7. This gene, which maps to the chemokine receptor gene cluster, is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver, spleen red pulp, intestine, lungs, and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells. CXCR6/CCL16 also controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes, which are an important first line of defense against respiratory pathogens. The encoded protein serves as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4. [provided by RefSeq, Aug 2020]
  • Clinical and Translational Updates

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