로그인 회원가입
icon_bulk_order대량 주문 Acrobiosystems for English
0
장바구니가 비어 있습니다
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: > Protein > IL-1 RII > IL2-H4226

Human IL-1 RII / CD121b Protein, His Tag

  • Synonym
    CD121b,IL1RB,IL1R2,CDw121b
  • Source
    Human IL-1 RII, His Tag(IL2-H4226) is expressed from human 293 cells (HEK293). It contains AA Phe 14 - Glu 343 (Accession # NP_004624.1).
    Predicted N-terminus: Phe 14
  • Molecular Characterization
    IL-1 RII Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 38.9 kDa. The protein migrates as 50-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >98% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
IL-1 RII SDS-PAGE

Human IL-1 RII, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 98% (With Star Ribbon Pre-stained Protein Marker).

Bioactivity-ELISA
 IL-1 RII ELISA

Immobilized Human IL-1 beta, Fc Tag (Cat. No. ILA-H525c) at 5 μg/mL (100 μL/well) can bind Human IL-1 RII, His Tag (Cat. No. IL2-H4226) with a linear range of 1-20 ng/mL (QC tested).

  • Background
    Interleukin-1 receptor type 2 (IL1R2) is also known as CD121 antigen-like family member B (CDw121b), IL-1 type II receptor, Interleukin-1 receptor type II, belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R2 is non-signaling receptor for IL1A, IL1B and IL1RN, reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
  • Clinical and Translational Updates

코멘트 (0)


재고상품 도착 날짜: 영업일 기준 4일

가격(KRW) : 390,000

가격(KRW) : 2,640,000

추천 제품
안티-His 항체

가격(KRW) : 360,000

가격(KRW) : 2,370,000

커플링 HRP Anti-His 항체

가격(KRW) : 375,000

가격(KRW) : 2,520,000

보급 및 전시



Datasheet & Documentation

DMF 신청
DMF (Drug Master File)

신제품

문의와 컨텐츠

This web search service is supported by Google Inc.

totop