로그인 회원가입
icon_bulk_order대량 주문 Acrobiosystems for English
0
장바구니가 비어 있습니다
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: > Protein > CD3 epsilon > CDE-HR2H4

HRP-Human CD3 epsilon Protein, His Tag

  • Synonym
    FLJ18683,T3E,TCRE,CD3E,CD3-epsilon
  • Source
    HRP-Human CD3 epsilon, His Tag(CDE-HR2H4) is expressed from human 293 cells (HEK293). It contains AA Asp 23 - Asp 126 (Accession # P07766-1).
    Predicted N-terminus: Asp 23
  • Molecular Characterization
    CD3 epsilon Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 12.6 kDa.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
Bioactivity-ELISA
 CD3 epsilon ELISA

Immobilized Mouse Anti Human CD3(SP-34) at 1 μg/mL (100 μL/well) can bind HRP-Human CD3 epsilon, His Tag (Cat. No. CDE-HR2H4) with a linear range of 1-20 ng/mL (QC tested).

 CD3 epsilon ELISA

Immobilized Human BCMA, His Tag (Cat. No. BCA-H522y) at 1 μg/mL (100 μL/well) can bind Bispecific BCMA×CD3 T cell-engaging Antibody with a linear range of 5-39 ng/mL when detected by HRP-Human CD3 epsilon, His Tag (Cat. No. CDE-HR2H4) (Routinely tested).

Bioactivity-SPR
 CD3 epsilon SPR

Bispecific T-cell Engager captured on Protein A Chip can bind HRP-Human CD3 epsilon, His Tag (Cat. No. CDE-HR2H4) with an affinity constant of 4.45 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

  • Background
    CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
  • Clinical and Translational Updates

코멘트 (0)


재고상품 출발날짜: 영업일 기준 4일

가격(KRW) : 525,000

가격(KRW) : 2,280,000

보급 및 전시



약물 개발 현황

  • Number of Launched Drugs:3 Details
  • Number of Drugs in Clinical Trials:7 Details
  • Latest Research Phase:Approved

Datasheet & Documentation

DMF 신청
DMF (Drug Master File)

관련 제품

신제품

문의와 컨텐츠

This web search service is supported by Google Inc.

totop