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Your Position: > Protein > LOXL2 > LO2-H52H3

Human LOXL2 Protein, His Tag (active enzyme)

  • 동의어
    Lysyl oxidase homolog 2,LOXL2
  • 출처
    Human LOXL2, His Tag (LO2-H52H3) is expressed from human 293 cells (HEK293). It contains AA Gln 26 - Gln 774 (Accession # Q9Y4K0-1).
    Predicted N-terminus: Gln 26
  • 분자 표징
    Online(Gln 26 - Gln 774) Q9Y4K0-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 86.0 kDa. The protein migrates as 100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 내독소
    Less than 1.0 EU per μg by the LAL method.
  • 순도

    >95% as determined by SDS-PAGE.

  • 레시피

    Supplied as 0.2 μm filtered solution in 20 mM MES, 50 mM NaCl, pH6.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 보관

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • 배송
    This product is supplied and shipped with dry ice, please inquire the shipping cost.
SDS-PAGE
Human LOXL2, His Tag (Cat. No. LO2-H52H3) SDS-PAGE gel

Human LOXL2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

생물 활성

Measured by its ability to produce hydrogen peroxide during the oxidation of benzylamine. The specific activity is >5 pmol/min/μg (QC tested).

  • 백그라운드
    Lysyl oxidase homolog 2 is also known as LOXL2, Lysyl oxidase-like protein 2, which is expressed in many tissues, highest expression in reproductive tissues, placenta, uterus and prostate, Up-regulated in a number of cancers cells and tissues. LOXL2 mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. LOXL2 acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. LOXL2 acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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재고상품 출발날짜: 영업일 기준 4일

가격(KRW) : 525,000

가격(KRW) : 3,960,000

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