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Your Position: 홈 > Protein > PDGF R alpha > PDA-H52H7

Human PDGF R alpha / PDGFRA Protein, His Tag

INTRODUCTION
QC & Assay Protocol
Citation & Background
  • Synonym
    PDGFRA,CD140A,PDGFR2,RHEPDGFRA,MGC74795
  • Source
    Human PDGF R alpha, His Tag(PDA-H52H7) is expressed from human 293 cells (HEK293). It contains AA Gln 24 - Ala 528 (Accession # P16234-1).
    Predicted N-terminus: Gln 24
    Request for sequence
  • Molecular Characterization
    PDGF R alpha Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 58.4 kDa. The protein migrates as 66-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
PDGF R alpha SDS-PAGE

Human PDGF R alpha, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

Bioactivity-ELISA
PDGF R alpha ELISA

Immobilized Human PDGF R alpha, His Tag (Cat. No. PDA-H52H7) at 5 μg/mL (100 μL/well) can bind HHV-5 (strain AD169) gH&gL&gO, Twin-Strep Tag&Tag Free&His Tag with a linear range of 5-39 ng/mL (Routinely tested).

Protocol
Bioactivity-SPR
PDGF R alpha SPR

Human PDGF R alpha, His Tag (Cat. No. PDA-H52H7) immobilized on CM5 Chip can bind HHV-5 (strain AD169) gH&gL&gO, Twin-Strep Tag&Tag Free&His Tag with an affinity constant of 0.155 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
  • Background
    PDGFRA(platelet-derived growth factor receptor A), also termed PDGFRα(platelet-derived growth factor receptor α), is a receptor located on the surface of a wide range of cell types. This receptor binds to certain isoforms of platelet-derived growth factors (PDGFs) and thereby becomes active in stimulating cell signaling pathways that elicit responses such as cellular growth and differentiation. The receptor is critical for the development of certain tissues and organs during embryogenesis and for the maintenance of these tissues and organs, particularly hematologic tissues, throughout life. Mutations in the gene which codes for PDGFRA, are associated with an array of clinically significant neoplasms.
  • Clinical and Translational Updates

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