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B7-H7

요약

Name:HERV-H LTR-associating protein 2
Target Synonym:Human endogenous retrovirus-H long terminal repeat-associating protein 2,B7-H7,B7H7
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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일부의 생물활성 데이터

B77-C52H3-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Cynomolgus B7-H7, His Tag (Cat. No. B77-C52H3) on HIS1K Biosensor, can bind Human CD28H, Fc Tag (Cat. No. CDH-H5251) with an affinity constant of 13.3 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

B77-H52H5-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human B7-H7, His Tag (Cat. No. B77-H52H5) on HIS1K Biosensor, can bind Human CD28H, Fc Tag (Cat. No. CDH-H5251) with an affinity constant of 16.4 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

B7-H7,HHLA2,B7 Homolog 7

Background

B7-H7 (HHLA2) is a newly identified B7 family member that regulates human T-cell functions. B7-H7 was previously known as human endogenous retrovirus-H long terminal repeat associating 2 (HHLA2) with unidentified function. Recently, B7-H7 has been identified as a specific ligand for human CD28H. The B7-H7-CD28H pathway strongly promoted CD4+ T-cell proliferation and cytokine production via an AKT-dependent signaling cascade in the presence of TCR signaling, suggesting B7-H7 comprises a new co-stimulatory pathway. The first IgV domain of B7-H7, which presumably binds to a putative receptor, shows the highest homology to other B7 family members.

Clinical and Translational Updates

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