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EMMPRIN

요약

Name:Basigin
Target Synonym:BSG,Extracellular matrix metalloproteinase inducer,UNQ6505/PRO21383,Basigin (Ok Blood Group),Tumor Cell-Derived Collagenase Stimulatory Factor,Leukocyte Activation Antigen M6,Collagenase Stimulatory Factor,Basigin,5F7,Ok Blood Group,CD147 Antigen,EMPRIN,CD147,OK,TCSF,EMMPRIN,SLC7A11,OK blood group antigen
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Approved

제품 리스트 비교 또는 구매

일부의 생물활성 데이터

CD7-H82E0-ELISA
Biotinylated Human EMMPRIN, Avitag,His TagBiotinylated Human EMMPRIN, Avitag,His Tag (Cat. No. CD7-H82E0) ELISA bioactivity

Immobilized Biotinylated Human EMMPRIN, Avitag,His Tag (Cat. No. CD7-H82E0) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-EMMPRIN Antibody, Mouse IgG1 with a linear range of 0.1-4 ng/mL (QC tested).

CD7-M82E8-MALS-HPLC
Biotinylated Human EMMPRIN, His,Avitag (Cat. No. ) MALS images

The purity of Biotinylated Human EMMPRIN, His,Avitag (Cat. No. CD7-M82E8) is more than 85% and the molecular weight of this protein is around 28-42kDa verified by SEC-MALS.

  • Background
    CD147, also known as Basigin (BSG), or extracellular matrix metalloproteinase inducer (EMMPRIN). The human basigin protein contains 269 amino acids that form two heavily glycosylated C2 type immunoglobulin-like domains at the N-terminal extracellular portion. A second form of basigin has also been characterized that contains one additional immunoglobulin-like domain in its extracellular portion. As members of the immunoglobulin superfamily play fundamental roles in intercellular recognition involved in various immunologic phenomena, differentiation, and development, basigin is thought also to play a role in intercellular recognition and regulate several distinct functions, such as spermatogenesis, expression of the monocarboxylate transporter and the responsiveness of lymphocytes. Basigin is a type I integral membrane receptor that has many ligands, including the cyclophilin (CyP) proteins Cyp-A and CyP-B and certain integrins.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

Synonym Name

Basigin,BSG,5F7,CD147,EMMPRIN,M6,OK,TCSF

Background

CD147, also known as Basigin (BSG), or extracellular matrix metalloproteinase inducer (EMMPRIN). The human basigin protein contains 269 amino acids that form two heavily glycosylated C2 type immunoglobulin-like domains at the N-terminal extracellular portion. A second form of basigin has also been characterized that contains one additional immunoglobulin-like domain in its extracellular portion. As members of the immunoglobulin superfamily play fundamental roles in intercellular recognition involved in various immunologic phenomena, differentiation, and development, basigin is thought also to play a role in intercellular recognition and regulate several distinct functions, such as spermatogenesis, expression of the monocarboxylate transporter and the responsiveness of lymphocytes. Basigin is a type I integral membrane receptor that has many ligands, including the cyclophilin (CyP) proteins Cyp-A and CyP-B and certain integrins.

Clinical and Translational Updates

공개 약품 정보

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Iodine[131I] Metuximab Approved Chengdu Huasun Biotechnology Co Ltd 利卡汀, Licartin Mainland China Carcinoma, Hepatocellular Chengdu Huasun Biotechnology Co Ltd 2006-10-12 Carcinoma, Hepatocellular Details

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
Mertuzumab Phase 3 Clinical Jiangsu Pacific-Meinuoke Bio-Pharmaceutical Co Ltd, Institute Of Medicine Fourth Military Medical University Coronavirus Disease 2019 (COVID-19); Carcinoma, Non-Small-Cell Lung Details
89Zr-CD147 Beijing Xiantong International Technology Co Ltd Details
Meplazumab HI6H8 Jiangsu Pacific-Meinuoke Bio-Pharmaceutical Co Ltd, Institute Of Medicine Fourth Military Medical University Details
Anti-CD147 CAR T cell therapy (Xijing Hospital) The First Affiliated Hospital of Air Force Medical University Details
CD147-CAR T cell therapy (Peking University People's Hospital) Phase 1 Clinical Peking University People'S Hospital Lymphoma, T-Cell Details

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