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Her2

요약

Name:Receptor protein-tyrosine kinase erbB-2
Target Synonym:EC 2.7.10.1,HER-2/Neu,Herstatin,HER-2,TKR1,Receptor, ErbB-2,V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog,V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncoprotein 2,Neuroblastoma/Glioblastoma Derived Oncogene Homolog,C-Erb B2/Neu Protein,CD340 Antigen,EC:2.7.10.1,EC 2.7.10,MLN 19,CD340,Tyrosine kinase-type cell surface receptor HER2,Receptor tyrosine-protein kinase erbB-2,ERBB2,MLN19,Proto-oncogene Neu,Erb-B2 Receptor Tyrosine Kinase 2,V-E
Number of Launched Drugs:30
Number of Drugs in Clinical Trials:165
Lastest Research Phase:Approved

제품 리스트 비교 또는 구매

제품번호 제품 설명 구조 순도 특징
HE2-HA2H7 Human APC-Labeled Human Her2 / ErbB2 Protein, His Tag (Site-specific conjugation)
HE2-HA2H7-structure
HE2-R52H8 Rabbit Rabbit Her2 / ErbB2 Protein, His Tag
HE2-R52H8-structure
HE2-R52H8-sds
HE2-HF256 Human FITC-Labeled Human Her2 / ErbB2 Protein, Fc Tag
HE2-HF256-structure
HE2-HF256-sds
HE2-HP2E3 Human PE-Labeled Human Her2 / ErbB2 Protein, His Tag (Site-specific conjugation)
HE2-HP2E3-structure
HE2-H52H9 Human Human Her2 / ErbB2 (23-510) Protein, His Tag (MALS verified)
HE2-H52H9-structure
HE2-H52H9-sds
HE2-H52H3 Human Human Her2 / ErbB2 (S310Y) Protein, His Tag (MALS verified)
HE2-H52H3-structure
HE2-H52H3-sds
HE2-H52H2 Human Human Her2 / ErbB2 (S310F) Protein, His Tag
HE2-H52H2-structure
HE2-H52H2-sds
MBS-K006 Human Human HER2-coupled Magnetic Beads
HE2-H52H4 Human Human Her2 / ErbB2 (498-648) Protein, His Tag
HE2-H52H4-structure
HE2-H52H4-sds
HE2-HF224 Human FITC-Labeled Human Her2 / ErbB2 Protein, His Tag
HE2-HF224-structure
HE2-HF224-sds
HE2-H5255 Human Human Her2 / ErbB2 Protein, Mouse IgG2a Fc Tag (MALS verified)
HE2-H5255-structure
HE2-H5255-sds
HE2-C82E3 Cynomolgus Biotinylated Cynomolgus Her2 / ErbB2 Protein, His,Avitag™ (MALS verified)
HE2-C82E3-structure
HE2-C82E3-sds
HE2-H5212 Human Human Her2 / ErbB2 Protein, Tag Free
HE2-H5212-structure
HE2-H5212-sds
HE2-C52Hb Cynomolgus Cynomolgus Her2 / ErbB2 Protein, His Tag (MALS verified)
HE2-C52Hb-structure
HE2-C52Hb-sds
EHH-V1 Human ELISA Assay Kit for Anti-HER-2 h-mAb in Human Serum
EHM-V1 Mouse ELISA Assay Kit for Anti-HER-2 h-mAb in Mouse Serum
EHC-V1 Monkey ELISA Assay Kit for Anti-HER-2 h-mAb in Monkey Serum
HE2-H82E2 Human Biotinylated Human Her2 / ErbB2 Protein, His,Avitag™
HE2-H82E2-structure
HE2-H82E2-sds
HE2-H525x Human Human Her2 / ErbB2 (23-450) Protein, Fc Tag
HE2-H525x-structure
HE2-H525x-sds
HE2-H822R Human Biotinylated Human Her2 / ErbB2 Protein, His Tag, ultra sensitivity (primary amine labeling, long spacer)
HE2-H822R-structure
HE2-H822R-sds
HE2-H5287 Human Human Her2 / ErbB2 Protein, Strep Tag
HE2-H5287-structure
HE2-H5287-sds
ER2-M5220 Mouse Mouse Her2 / ErbB2 Protein, His Tag
ER2-M5220-structure
ER2-M5220-sds
HE2-H5253 Human Human Her2 / ErbB2 Protein, Fc Tag
HE2-H5253-structure
HE2-H5253-sds
HE2-H5225 Human Human Her2 / ErbB2 Protein, His Tag (MALS verified)
HE2-H5225-structure
HE2-H5225-sds

일부의 생물활성 데이터

HE2-HA2H7-Cell-based assay
 Her2 FACS

5e5 of anti-Her2 CAR-293 cells were stained with 100 μL of 1:25 dilution (4 μL stock solution in 100 μL FACS buffer) of APC-Labeled Human Her2, His Tag (Cat. No. HE2-HA2H7) and negative control protein respectively. APC signal was used to evaluate the binding activity (QC tested).

HE2-HP2E3-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

5e5 of anti-Her2 CAR-293 cells were stained with 100 μL of 1:25 dilution (4 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human Her2, His Tag (Cat. No. HE2-HP2E3) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).

HE2-H82E2-SPR
Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Human Her2, His,Avitag (Cat. No. HE2-H82E2) immobilized on SA Chip can bind Herceptin® with an affinity constant of 17 pM as determined in a SPR assay (Biacore T200) (Routinely tested).

HE2-H5225-SPR
Human_FcRn_Heterodimer_Protein_SPR

Herceptin (Trastuzumab) captured on CM5 chip via anti-human IgG Fc antibodies surface, can bind Human Her2, His Tag (Cat. No. HE2-H5225) with an affinity constant of 1.07 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

사용자 리뷰

Synonym Name

ERBB2,CD340,HER-2/neu,HER2,MLN19,NEU,NGL,TKR1

Background

Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2 /neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation .

Clinical and Translational Updates

공개 약품 정보

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Trastuzumab biosimilar (AryoGen Pharmed) Approved Aryogen Biopharma AryoTrust Stomach Neoplasms; Breast Neoplasms Details
Trastuzumab/Hyaluronidase Approved Genentech Inc Herceptin Hylecta United States Breast Neoplasms Genentech Inc 2019-02-28 Breast Neoplasms Details
Trastuzumab biosimilar (Dr. Reddy's Laboratories) Approved Dr Reddy's Laboratories Ltd Hervycta India Breast Neoplasms Dr Reddy's Laboratories Ltd 2018-07-26 Breast Neoplasms Details
Trastuzumab biosimilar (Intas Pharmaceuticals) Approved Intas Biopharmaceuticals Breast Neoplasms Details
Trastuzumab biosimilar (AXXO) Approved Axxo Breast Neoplasms Details
Trastuzumab biosimilar (Reliance Life Sciences) R-TPR-016 Approved Reliance Life Sciences TrastuRel India Breast Neoplasms Reliance Life Sciences 2015-01-01 Breast Neoplasms Details
Trastuzumab biosimilar (Zydus) Approved Zydus Cadila Vivitra India Breast Neoplasms Zydus Cadila 2016-01-01 Breast Neoplasms Details
Inetetamab CMAB-302 Approved Shanghai Cp Guojian Pharmaceutical Co Ltd Cipterbin, 赛普汀 Mainland China Breast Neoplasms Shanghai Cp Guojian Pharmaceutical Co Ltd 2020-06-17 Breast Neoplasms Details
Trastuzumab biosimilar (Biocad) BCD-022 Approved Biocad HERtiCAD Russian Federation Breast Neoplasms Biocad 2016-01-01 Breast Neoplasms Details
Trastuzumab biosimilar (Biocon/Mylan) Bmab-200; Myl-1401O; HerMyl-1401O Approved Biocon, Mylan Nv CANMAb, Ogivri, Zedora, Hertraz EU Breast Neoplasms; Stomach Neoplasms Viatris Ltd 2013-01-01 Stomach Neoplasms; Esophageal Neoplasms; Breast Neoplasms Details
Trastuzumab biosimilar (Pfizer) PF-5280014; PF-05280014 Approved Pfizer Inc Trazimera Japan Breast Neoplasms; Stomach Neoplasms Pfizer Inc 2018-07-26 Stomach Neoplasms; Breast Neoplasms Details
Margetuximab MGAH-22 Approved Macrogenics Margenza United States Breast Neoplasms Macrogenics Inc 2020-12-16 Ovarian Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Urinary Bladder Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Trastuzumab biosimilar (Synthon) ABP-980 Approved Synthon Bv Kanjinti United States Breast Neoplasms; Stomach Neoplasms Amgen Inc 2018-05-16 Stomach Neoplasms; Breast Neoplasms Details
Trastuzumab biosimilar (Samsung Bioepis) SB-3; AMT-901 Approved Samsung Bioepis Samfenet, Ontruzant United States Breast Neoplasms; Stomach Neoplasms Samsung Bioepis Co Ltd 2017-11-15 Stomach Neoplasms; Breast Neoplasms Details
Dacomitinib PF-299; PF-804; PF-299804; PF-00299804; PF-00299804-3; PF-00299804-03 Approved Pfizer Inc Vizimpro Mainland China Carcinoma, Non-Small-Cell Lung Pfizer Europe Ma Eeig 2018-09-27 Head and Neck Neoplasms; Solid tumours; Stomach Neoplasms; Squamous Cell Carcinoma of Head and Neck; Neoplasms; Glioblastoma; Liver Diseases; Brain Neoplasms; Colorectal Neoplasms; Mouth Neoplasms; Esophageal Squamous Cell Carcinoma; Lung Neoplasms; Penile Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details
Trastuzumab R-597; RO45-2317; Anti-HER2/neu-MAb; huMAb4D5-8; RG-597; MKC-454 Approved Genentech Inc Herceptin, 赫赛汀 Mainland China Stomach Neoplasms Roche Pharma (Schweiz) Ag 1998-09-25 Neoplastic Cells, Circulating; Ependymoma; Leukemia; Head and Neck Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Meningeal Carcinomatosis; Neoplasms; Breast Neoplasms; Urologic Neoplasms; Esophageal Squamous Cell Carcinoma; Endometrial Neoplasms; Vulvar Diseases; Adenocarcinoma Details
Trastuzumab biosimilar (Celltrion) CT-P6; CT-P06 Approved Celltrion Herzuma United States Breast Neoplasms Celltrion Inc 2014-01-01 Stomach Neoplasms; Breast Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Disitamab Vedotin RC-48-ADC; RC48-ADC; RC-48 Approved RemeGen Co Ltd 爱地希 Mainland China Carcinoma, Transitional Cell RemeGen Co Ltd 2021-06-08 Biliary Tract Neoplasms; Solid tumours; Stomach Neoplasms; Genital Diseases, Female; Esophageal Neoplasms; Carcinoma; Carcinoma, Transitional Cell; Neoplasms; Urinary Bladder Neoplasms; Breast Neoplasms; Bile Duct Neoplasms; Genital Neoplasms, Female; Carcinoma, Non-Small-Cell Lung; Melanoma Details
Lapatinib Ditosylate Hydrate GW-572016; GW-572016F; GW-2016 Approved Glaxosmithkline Plc, Novartis Pharma Ag Tykerb, Tyverb, 泰立沙, Tykerb/Tyverb Mainland China Breast Neoplasms Glaxosmithkline Ag 2007-03-13 Colorectal Neoplasms; Breast Neoplasms, Male; Neuroma, Acoustic; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Gastrointestinal Neoplasms; Uterine Cervical Neoplasms; Adenocarcinoma; Lung Neoplasms; Glioma; Carcinoma, Squamous Cell; Carcinoma, Ductal, Breast; Solid tumours; Prostatic Neoplasms; Breast Neoplasms; Urinary Bladder Neoplasms; Neurofibromatosis 2; Neoplasms; Carcinoma; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Esophageal Neoplasms; Stomach Neoplasms; Head and Neck Neoplasms Details
Neratinib Maleate CAN-030; HKI-272; PF-0528767; WAY-179272; PB-272 Approved Pfizer Pharmaceuticals Ltd (China) Nerlynx, 贺俪安 Mainland China Breast Neoplasms Excella Gmbh & Co Kg 2017-07-17 Solid tumours; Leukemia; Triple Negative Breast Neoplasms; Glioblastoma; Neoplasms; Central Nervous System Neoplasms; Prostatic Neoplasms, Castration-Resistant; Breast Neoplasms; Prostatic Neoplasms; Hepatic Insufficiency; Lung Neoplasms; Lymphoma; Carcinoma, Non-Small-Cell Lung Details
Fam-trastuzumab deruxtecan DS-8201a; DS-8201 Approved Daiichi Sankyo Co Ltd Enhertu EU Breast Neoplasms Daiichi Sankyo Europe Gmbh 2019-12-20 Breast Neoplasms; Carcinoma, Endometrioid; Gastrointestinal Neoplasms; Uterine Cervical Neoplasms; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Brain metastases; Metastatic breast cancer; Meningeal Neoplasms; Colorectal Neoplasms; Ovarian Neoplasms; Urinary Bladder Neoplasms; Neoplasms, Glandular and Epithelial; Pancreatic Neoplasms; Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Solid tumours; Biliary Tract Neoplasms Details
Trastuzumab emtansine biosimilar (Zydus Cadila) ZRC-3256 Approved Zydus Cadila Ujvira India Breast Neoplasms Zydus Cadila 2021-05-24 Breast Neoplasms Details
Trastuzumab biosimilar (Shanghai Henlius Biotech) HLX-02 Approved Shanghai Henlius Biotech Co Ltd Zercepac, 汉曲优 Australia Stomach Neoplasms; Breast Neoplasms Cipla Australia Pty Ltd 2020-07-27 Stomach Neoplasms; Neoplasms; Breast Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Trastuzumab/Pertuzumab RO-7198574; RG-6264 Approved F. Hoffmann-La Roche Ltd Phesgo EU Breast Neoplasms Roche Registration Gmbh 2020-06-29 Solid tumours; Ovarian Neoplasms; Breast Neoplasms; Metastatic breast cancer Details
Ado-trastuzumab emtansine RG-3502; R-3502; T-DM1; PRO-132365; RO-5304020 Approved Genentech Inc Kadcyla, 赫赛莱 Mainland China Breast Neoplasms Roche Pharma (Schweiz) Ag 2013-02-22 Ovarian Neoplasms; Solid tumours; Stomach Neoplasms; Pancreatic Neoplasms; Neoplasms; Salivary Gland Neoplasms; Urinary Bladder Neoplasms; Breast Neoplasms; Cholangiocarcinoma; Urologic Neoplasms; Lung Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
Pertuzumab RG-1273; RO-4368451-F01; rhuMab-2C4; RO-4368451; R-1273 Approved Genentech Inc Perjeta, Omnitarg Mainland China Breast Neoplasms Roche Pharma (Schweiz) Ag 2012-06-08 Solid tumours; Ovarian Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Inflammatory Breast Neoplasms; Neoplasms; Multiple Myeloma; Breast Neoplasms; Prostatic Neoplasms; Carcinoma, Ductal, Breast; Lymphoma, Non-Hodgkin; Neoplasms, Unknown Primary; Metastatic breast cancer; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Breast Neoplasms, Male Details
Osimertinib Mesylate AZD-9291 Mesylate; AZD9291; AZD-9291; RDL94R2A16 Approved Astrazeneca Pharmaceutical Co Ltd 泰瑞沙, Tagrisso Mainland China Carcinoma, Non-Small-Cell Lung Astrazeneca Ab 2015-11-13 Lung Diseases; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Brain metastases; Lung Neoplasms; Neoplasms, Nerve Tissue; Meningeal Neoplasms; Respiratory Tract Neoplasms; Solid tumours; Respiratory Tract Diseases; Neoplasms; Glioblastoma; Carcinoma; Bronchial Neoplasms; Thoracic Neoplasms; Carcinoma, Bronchogenic Details
Pyrotinib Maleate HTI-1001; SHR-1258; BLTN Approved Jiangsu Hengrui Medicine Co Ltd 艾瑞妮 Mainland China Breast Neoplasms Jiangsu Hengrui Medicine Co Ltd 2018-08-12 Solid tumours; Biliary Tract Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Adenocarcinoma of Lung; Neoplasms; Triple Negative Breast Neoplasms; Breast Neoplasms; Bile Duct Neoplasms; Colorectal Neoplasms; Metastatic breast cancer; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Gastrointestinal Neoplasms; Neoplasm Metastasis Details
Tucatinib ARRY-380; ONT-380; MK-7119 Approved Array Biopharma Tukysa EU Breast Neoplasms Seagen Netherlands Bv 2020-04-17 Solid tumours; Stomach Neoplasms; Esophageal Neoplasms; Neoplasms; Breast Neoplasms; Hepatic Insufficiency; Colorectal Neoplasms; Metastatic breast cancer; Carcinoma, Non-Small-Cell Lung Details
Afatinib Dimaleate BIBW-2992; BIBW-2992-MA2 Approved C.H. Boehringer Sohn Ag & Co. Kg Gilotrif, Tomtovok, 吉泰瑞, Tovok, Giotrif Mainland China Carcinoma, Non-Small-Cell Lung Boehringer Ingelheim International Gmbh 2013-07-12 Breast Neoplasms; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Gallbladder Neoplasms; Esophageal Squamous Cell Carcinoma; Lymphoma, Non-Hodgkin; Uterine Neoplasms; Lung Neoplasms; Carcinoma, Squamous Cell; Ureteral Neoplasms; Colorectal Neoplasms; Urologic Neoplasms; Urethral Neoplasms; Brain Neoplasms; Head and Neck Neoplasms; Liver Diseases; Urinary Bladder Neoplasms; Multiple Myeloma; Chordoma; Endometriosis; Neuroectodermal Tumors; Neoplasms; Renal Insufficiency; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Rhabdomyosarcoma; Solid tumours Details

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
Recombinant anti-HER2 humanized monoclonal antibody (Shenzhen Main Luck Pharmaceuticals) Phase 1 Clinical Shenzhen Main Luck Pharmaceuticals Inc Breast Neoplasms Details
[18F]GE-226 ABY-002; ABY-025; ABY-0125; 68GaABY025; GE-226; [68Ga]-ABY-025; GE-226-[18F]; [111]In-ABY-025; ABY-025-[68Ga]; ABY-025-[111In]; Gallium-68-ABY-025; Indium-111-ABY-025; Fluorine-18-GE-226 Phase 3 Clinical Affibody Breast Neoplasms Details
Pertuzumab biosimilar (CTTQ) TQB-2440 Phase 3 Clinical Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd Breast Neoplasms Details
Recombinant humanized anti-HER2 antibody (Hisun Pharma) Phase 3 Clinical Zhejiang Hisun Pharmaceutical Co Ltd Breast Neoplasms Details
JRF-103 JRF103; JRF-103 Phase 2 Clinical Shenzhen Jinrui Foundation Biotechnology Co Ltd Solid tumours Details
Recombinant anti-HER2 humanized HuA21 monoclonal antibody(Hankemab) Phase 1 Clinical Hefei Hankemab Biotechnology Co Ltd Solid tumours Details
HER-2 Specific CAR T Cell Phase 1 Clinical Ependymoma Details
XZP-5209 XZP-5209 Phase 1 Clinical Carcinoma, Non-Small-Cell Lung Details
Trastuzumab biosimilar(Aprogen/Nichi-Iko) AP-06 Phase 3 Clinical Nichi-Iko Pharmaceutical Co Ltd, Aprogen Breast Neoplasms Details
Anti-HER2 CAR T-cell therapy (Baylor College of Medicine/The Hospital for Sick Children/Texas Children's Hospital/The Methodist Hospital System ) Phase 1 Clinical Baylor College Of Medicine, The Hospital For Sick Children, Texas Children'S Hospital, The Methodist Hosp Research Institute Sarcoma Details
SSGJ-706 SSGJ-706 Phase 1 Clinical Shanghai Cp Guojian Pharmaceutical Co Ltd Solid tumours; Lymphoma Details
PM-3002 PM-3002 Phase 1 Clinical Biotheus Inc Details
99mTc- ADAPT6 99mTc- ADAPT6; ADAPT6; SNA-018 Phase 1 Clinical Uppsala University, Kth Royal Institute Of Technology Breast Neoplasms Details
BAY-2701439 BAY-2701439 Phase 1 Clinical Bayer AG Neoplasms Details
99mTc-HPArk2 99mTc-HPArk2; 99-mTc-HPArk-2 Phase 1 Clinical Peking Union Medical College Hospital Breast Neoplasms Details
TAA-013 TAA-013 Phase 3 Clinical Tot Biopharm Co Ltd Breast Neoplasms Details
HL-02 HL-02 Phase 3 Clinical Hualan Genetic Engineering Co Ltd Breast Neoplasms Details
NeuCeptin NeuCeptin Phase 1 Clinical Neuclone, Serum Institute Of India Stomach Neoplasms; Breast Neoplasms Details
TGFBeta-resistant-HER2-EBV-CTLs TGFBeta-resistant-HER2-EBV-CTLs Phase 1 Clinical Baylor College Of Medicine Neoplasms Details
Trastuzumab biosimilar (United BioPharma) UB-921 Phase 1 Clinical United Biopharma Inc Breast Neoplasms Details
IBPM002BZ (Inbiopro Solutions) IBPM-002BZ Clinical Inbiopro Solutions Carcinoma, Renal Cell; Small Cell Lung Carcinoma; Colorectal Neoplasms Details
Autologous AdHER2 dendritic cell vaccine (National Cancer Institute) Phase 1 Clinical National Cancer Institute Neoplasms Details
trastuzumab biosimilar (Hetero) Ado-Trastuzumab biosimilar (Hetero) Phase 3 Clinical Hetero Drugs Neoplasms Details
HER.CAR-CMV-specific-CTLs HER.CAR-CMV-specific-CTLs Phase 1 Clinical Baylor College Of Medicine Glioblastoma Details
Trastuzumab biosimilar (Hualan Biological Engineering) Phase 1 Clinical Hualan Genetic Engineering Co Ltd Stomach Neoplasms; Breast Neoplasms Details
IBPM003TZ (Inbiopro Solutions) IBPM-003TZ Clinical Inbiopro Solutions Breast Neoplasms Details
PB-357 PB-357 Phase 1 Clinical Pfizer Inc Neoplasms Details
Trastuzumab biosimilar (BioIntegrator) BI-Mab-03 Phase 1 Clinical Biointegrator Breast Neoplasms Details
4-1BBz CD19-Her2tG (Seattle Children's Hospital) Phase 1 Clinical Seattle Children'S Hospital Neoplasms Details
Pertuzumab biosimilar(SL Pharma/Combio) Phase 1 Clinical Beijing Sl Pharmaceutical Co Ltd Inflammatory Breast Neoplasms; Breast Neoplasms; Metastatic breast cancer Details
Anti-HER2 CAR T-cell therapy (Seattle Children's Hospital) Phase 1 Clinical Seattle Children'S Research Institute Central Nervous System Neoplasms Details
KSP-QRH-E3-IRDye800 Phase 1 Clinical University Of Michigan Cholangiocarcinoma Details
Autologous-HER2-specific-T-cells Autologous-HER2-specific-T-cells Phase 1 Clinical Baylor College Of Medicine Sarcoma Details
Recombinant anti-HER2 human monoclonal antibody-DM1 (Hisun Pharm/Mabworks Biotech) HS-630; HS630 Phase 1 Clinical Zhejiang Hisun Pharmaceutical Co Ltd, Beijing Mabworks Biotech Co Ltd Breast Neoplasms Details
SHR-A1201 SHR-A1201 Phase 1 Clinical Jiangsu Hengrui Medicine Co Ltd Breast Neoplasms Details
TT-16 TT-16 Phase 1 Clinical Tessa Therapeutics Solid tumours Details
KSP-910638-G KSP-910638G; KSP-910638-G Phase 1 Clinical University Of Michigan Gastrointestinal Neoplasms Details
Anti-CD3 and anti-HER2 BiTE-expressing T cell (MedImmune) Phase 2 Clinical University Of Michigan, Huazhong University Of Science And Technology, University Of Virginia Cancer Center, Medimmune Breast Neoplasms Details
Trastuzumab biosimilar (NeuClone/Serum Institute of India) Phase 1 Clinical Serum Institute Of India, Neuclone Stomach Neoplasms; Breast Neoplasms Details
AU-101 AU-101 Phase 2 Clinical Aurora Biopharma Glioblastoma; Osteosarcoma; Breast Neoplasms Details
68Ga-anti-HER2 nanobodies (Universite Libre de Bruxelles) Phase 1 Clinical Universite Libre De Bruxelles Breast Neoplasms Details
MB-103 MB-103 Phase 1 Clinical Mustang Bio, City Of Hope National Medical Center Glioblastoma; Brain metastases Details
MX-402 MX-402 Phase 1 Clinical Medvax Technologies Stomach Neoplasms Details
Recombinant anti-HER2 subdomain II humanized monoclonal antibody(Livzon) LZM-005 Phase 1 Clinical Livzon Pharmaceutical Group Inc Breast Neoplasms Details
Trastuzumab biosimilar (BioXpress) BXT-2318; BX-2318 Clinical Bioxpress Therapeutics Sa Stomach Neoplasms; Metastatic breast cancer Details
99m-Tc labeled anti-HER2 single domain antibody (NanoMab) 99mTc-NM-02 Phase 1 Clinical Nanomab Technology Ltd Breast Neoplasms Details
HER2(EQ)BBzeta/CD19 T cells (City of Hope) Phase 1 Clinical Mustang Bio, City Of Hope National Medical Center Glioma Details
CIDeCAR Phase 1 Clinical Bellicum Pharmaceuticals, National Cancer Institute Osteosarcoma Details
Pertuzumab biosimilar (Xuanzhu/SL) KM-118; KM118; XZP-KM118 Phase 1 Clinical Beijing Sl Pharmaceutical Co Ltd Breast Neoplasms Details
EX-101 EX-101; EX101 Phase 1 Clinical Guangzhou ASM Biomedical Technology Co Ltd Solid tumours Details
SSGJ-612 SSGJ-612 Phase 1 Clinical Shanghai Cp Guojian Pharmaceutical Co Ltd Solid tumours Details
SSGJ-705 SSGJ-705 Phase 1 Clinical Shanghai Cp Guojian Pharmaceutical Co Ltd Solid tumours; Neoplasms Details
Pertuzumab biosimilar (CinnaGen) Phase 3 Clinical Cinnagen Breast Neoplasms Details
Sirotinib Maleate XZP-5491 Phase 1 Clinical Shandong Xuanzhu Pharmaceutical Technology Co Ltd Stomach Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung Details
GB-251 GB-251; NBT-828; GB221-NBT828 ADC-1 Phase 1 Clinical Genor Biopharma Co Ltd, Newbio Therapeutics Inc Breast Neoplasms; Metastatic breast cancer Details
Puvitinib Phase 1 Clinical Suzhou Teligene Ltd Solid tumours Details
KY-1701 KY-1701 Phase 1 Clinical Jiangsu Kanion Pharmaceutical Co Ltd Breast Neoplasms Details
GB-235 GB-235 Phase 1 Clinical Genor Biopharma Co Ltd Breast Neoplasms Details
89Zr-ss-Pertuzumab Phase 1 Clinical Genentech Inc Breast Neoplasms; Metastatic breast cancer Details
Pertuzumab biosimilar (Jushi Biopharmaceutical ) Phase 1 Clinical Jushi Biopharmaceutical Co Ltd Breast Neoplasms; Metastatic breast cancer Details
Epertinib S-222611 Phase 2 Clinical Shionogi & Co Ltd Neoplasms Details
AU-105 AU-105 Phase 2 Clinical Aurora Biopharma Glioblastoma Details
99mTc-DARPinG3 99mTc-DARPinG3; 99mTc-DARPinG-3 Clinical Tomsk National Research Medical Center Of The Russian Academy Of Sciences Breast Neoplasms Details
I-025-A I-025-A Phase 1 Clinical Shanghai Pharmaceuticals Holding Co Ltd Breast Neoplasms Details
NIP-142 NIP-142 Phase 1 Clinical National Institutes Of Pharmaceutical Research And Development Co Ltd Carcinoma, Non-Small-Cell Lung Details
Trastuzumab biosimilar (Zhejiang Hisun Pharmaceutical) HS-022 Phase 1 Clinical Zhejiang Hisun Pharmaceutical Co Ltd Breast Neoplasms Details
Trastuzumab conjugate (BioIntegrator) BI-CON-02 Biointegrator Details
ETBX-021 ETBX-021 Nantbioscience, Etubics Corporation Details
anti-HER2 ADC (Pfizer) PF-06804103 Pfizer Inc Details
HER2/neu cancer vaccine (University of Washington/Corixa/GSK) University Of Washington Details
CP-724714 CP-724714 Pfizer Pharmaceuticals Ltd (China) Details
Mubritinib TAK-165 Takeda Pharmaceutical Co Ltd Details
Gancotamab MM-302 Merrimack Details
AEE-788 AEE-788; NVP-AEE-788 Novartis Pharma Ag Details
BMS-690514 BMS-690514 Bristol-Myers Squibb Company Details
Pirotinib Hydrochloride KBP-5209 Phase 2 Clinical Shandong Xuanzhu Pharmaceutical Technology Co Ltd Solid tumours; Breast Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Larotinib Mesylate Z-650 Phase 3 Clinical Guangdong Dongyangguang Pharmaceutical Co Ltd Solid tumours; Esophageal Neoplasms; Pancreatic Neoplasms; Esophageal Squamous Cell Carcinoma Details
ACE-1702 ACE-1702 Acepodia Taiwan Subsidiary Details
FCN-411 FCN-411 Phase 1 Clinical Shanghai Fosun Pharmaceutical (Group) Co Ltd Carcinoma, Non-Small-Cell Lung Details
MBS-301 MBS-301 Phase 1 Clinical Beijing Mabworks Biotech Co Ltd Stomach Neoplasms; Breast Neoplasms Details
GQ-1001 GQ-1001 Phase 1 Clinical GeneQuantum Healthcare (Suzhou) Co Ltd Solid tumours Details
DP-303c DP-303c; DP303c Phase 2 Clinical CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co Ltd Solid tumours; Ovarian Neoplasms; Stomach Neoplasms; Breast Neoplasms; Metastatic breast cancer Details
AIP-303 AIP-303 Advanced Imaging Projects Details
IAH-0968 IAH-0968; IAH0968 Phase 2 Clinical Shenghe (China) Biopharmaceutical Co Ltd Solid tumours Details
Pertuzumab biosimilar (Qilu Pharmaceutical) QL-1209 Phase 3 Clinical Qilu Pharmaceutical Co Ltd Breast Neoplasms Details
CT-0508 Phase 1 Clinical Carisma Therapeutics Inc Solid tumours; Biliary Tract Neoplasms; Stomach Neoplasms; Carcinoma, Ovarian Epithelial; Pancreatic Neoplasms; Carcinoma, Transitional Cell; Inflammatory Breast Neoplasms; Urinary Bladder Neoplasms; Carcinoma, Ductal; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Small Cell; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular Details
Dual-targeting HER2 and PD-L1 CAR-T Cell Therapy (Sichuan University) Sichuan University Details
TAC01-HER2 TAC01-HER2 Triumvira Immunologics Details
SPH-5030 SPH-5030 Phase 1 Clinical Shanghai Pharmaceuticals Holding Co Ltd Solid tumours Details
SAR-443216 SAR-443216 Sanofi Details
BAY-2927088 BAY-2927088; BAY2927088 Phase 1 Clinical Bayer Healthcare Company Ltd, Bayer AG Carcinoma, Non-Small-Cell Lung Details
99mTc-HE3-G3 99mTc-HE3-G3; 99-mTc-HE-3-G-3; 99m-Tc-HE-3-G-3; 99mTc-(HE)3-G3 Tomsk National Research Medical Center Of The Russian Academy Of Sciences Details
Recombinant anti-HER2 subdomain II and subdomain IV humanized monoclonal antibody(Xuanzhu) XZP-KM257; KM257/252; KM-257 Phase 1 Clinical Solid tumours Details
HER2/neu peptide vaccine (Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium) Fred Hutchinson/University Of Washington Cancer Consortium Details
Multiple 4SCAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute) Shenzhen Geno-Immune Medical Institute Details
Pertuzumab biosimilar (Shanghai Henlius Biotech) HLX-11 Phase 3 Clinical Shanghai Henlius Biotech Co Ltd Breast Neoplasms; Metastatic breast cancer Details
MP-412 AV-412; MP-412 Mitsubishi Tanabe Pharma Details
Sunvozertinib DZD-9008 Phase 2 Clinical Dizal (Jiangsu) Pharmaceutical Co Ltd Lymphoma, Non-Hodgkin; Carcinoma, Non-Small-Cell Lung Details
BDTX-189 BDTX-189 Black Diamond Therapeutics Details
AC-480 AC-480; BMS-599626 Bristol-Myers Squibb Company Details
ADCT-502 ADCT-502 Adc Therapeutics, Cancer Research Technology Details
AE-37/GP-2 vaccine AE-37 (Generex Biotechnology Corporation) Phase 2 Clinical Generex Biotechnology Corp Breast Neoplasms Details
BDC-1001 BDC-1001 Bolt Biotherapeutics Details
ALT-P7 HM2-MMAE; ALT-P7 Phase 1 Clinical Alteogen Inc Stomach Neoplasms; Breast Neoplasms Details
Coprelotamab GB-221 Phase 3 Clinical Genor Biopharma Co Ltd Breast Neoplasms Details
Anbenitamab KN-026 Phase 3 Clinical Suzhou Alphamab Co Ltd Solid tumours; Stomach Neoplasms; Esophageal Neoplasms; Breast Neoplasms Details
BVAC-B vaccine (Cellid) BVAC-B Cellid Company Details
XMT-1522 XMT-1522; TAK-522 Mersana Therapeutics Inc, Adimab Details
TAK-285 TAK-285 Takeda Details
HER2.taNK NK-92/5.28.z Nantkwest Inc Details
Sym-013 Sym-013 Symphogen Details
Cinrebafusp alfa PRS-343 Pieris Pharmaceuticals Details
A-166 A-166 Phase 2 Clinical Sichuan Kelun Pharmaceutical Co Ltd Solid tumours; Stomach Neoplasms; Esophageal Neoplasms; Carcinoma, Transitional Cell; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details
[89Zr]-Df-Trastuzumab University Of Alabama At Birmingham Details
Pertuzumab biosimilar(Hisun Pharm) HS-627; HS627 Phase 3 Clinical Zhejiang Hisun Pharmaceutical Co Ltd, Beijing Mabworks Biotech Co Ltd Breast Neoplasms Details
BCD-147 BCD-147 Biocad Details
M-802(Wuhan Yzy Biopharma/CSPC Pharmaceutical) M-802 Phase 1 Clinical Wuhan Yzy Biopharma Co Ltd, CSPC Pharmaceutical Group Ltd Solid tumours; Ovarian Neoplasms; Stomach Neoplasms; Breast Neoplasms Details
MM-111 MM-111 Merrimack Details
Tesevatinib XL-647; KD-020; KD-019; EXEL-7647 Exelixis Inc Details
Recombinant anti-HER2 humanized monoclonal antibody complex B-002 Phase 1 Clinical Shanghai Pharmaceuticals Holding Co Ltd Breast Neoplasms Details
ZN-A-1041 ZN-A-1041 Phase 1 Clinical Suzhou Zanrong Pharmaceutical Technology Co Ltd Solid tumours Details
Sapitinib AZD-8931 Astrazeneca Pharmaceutical Co Ltd Details
Tarloxotinib Bromide PR-610; TH-4000; SN-33999 Threshold Details
Fidasimtamab IBI-315 Phase 1 Clinical Hanmi Pharmaceutical Co Ltd, Innovent Biologics(Suzhou) Co Ltd Neoplasms Details
ARX-788 ARX-788; NCB-001 Phase 3 Clinical Ambrx Inc Solid tumours; Stomach Neoplasms; Esophageal Neoplasms; Breast Neoplasms Details
NJH-395 NJH-395 Novartis Pharma Ag Details
Ertumaxomab Trion Pharma, Neopharm Details
TAS-0728 TPC-107; TAS-0728 Taiho Pharmaceutical Co Ltd Details
BB-1701 BB-1701 Phase 1 Clinical Baili Sikang Biomedicine (Hangzhou) Co Ltd Solid tumours Details
MP-0274 DARPin-41; SPA-28; CME-114; CME-115; CME-118; CME-119; MP-0274 Molecular Partners Ag Details
TPIV-100 (TapImmune) TPIV-100 Mayo Clinic Details
Anti-HER2 monoclonal antibody-MCC-DM1 conjugate (Shanghai Pharma) B-003 (Shanghai Pharma) Phase 1 Clinical Shanghai Crosslink Pharmaceutical R & D Co Ltd, Shanghai Pharmaceuticals Holding Co Ltd Breast Neoplasms Details
Zanidatamab ZW-25 Phase 3 Clinical Zymeworks Inc Esophageal Neoplasms; Stomach Neoplasms; Breast Neoplasms; Bile Duct Neoplasms Details
MEDI-4276 MEDI-4276 Medimmune Llc Details
HER-2/Neu pulsed DC1 vaccine (University of Pennsylvania) University Of Pennsylvania, National Cancer Institute Details
GBR-1302 HBM-9302; GBR-1302 Glenmark Pharmaceuticals Ltd Details
MVA-BN-HER2 PX-1032; PX-103.2 Pharmexa, Bavarian Nordic A/S Details
RG-6148 RG-6148; DHES-0815A F. Hoffmann-La Roche Ltd Details
PLB-1004 PLB-1004 Phase 1 Clinical Beijing Anshi Biotechnology Co Ltd Carcinoma, Non-Small-Cell Lung Details
Recombinant anti-HER2 humanized monoclonal antibody (Shanghai Institute of Biological Products) SIBP-01 Phase 3 Clinical Shanghai Institute Of Biological Products Co Ltd Stomach Neoplasms; Breast Neoplasms Details
Hemay-022 Hemay-022 Phase 3 Clinical Tianjin Hemay Pharmaceutical Co Ltd, Xiajiang Hemei Pharmaceutical Co Ltd Breast Neoplasms; Foodborne Diseases Details
DZD-1516 DZD-1516 Phase 1 Clinical Dizal (Jiangsu) Pharmaceutical Co Ltd Breast Neoplasms Details
Pertuzumab biosimilar(Zydus Cadila) ZRC-3277 Phase 3 Clinical Zydus Cadila Breast Neoplasms Details
Recombinant anti-HER2 domain II humanized monoclonal antibody (Qilu Pharmaceutical) Phase 1 Clinical Qilu Pharmaceutical Co Ltd Breast Neoplasms Details
Recombinant human ErbB3 fragment vaccine (Zensun) rhErbB3-f Phase 1 Clinical Zensun (Shanghai) Sci&Tech Co Ltd Neoplasms Details
Trastuzumab biosimilar (Hanwha Biologics) HD-201 Phase 3 Clinical Hanwha Biologics Kidney Neoplasms; Breast Neoplasms Details
Recombinant Humanized Anti-Human Epidermal Growth Factor Receptor Monoclonal Antibody and the Dolastatins Derivative DUO5 Conjugated ZV0203; ZV203 Phase 1 Clinical Zhejiang Hisun Pharmaceutical Co Ltd, Zhejiang Zova Biotherapeutics Inc, Concortis Biosystems Corp Solid tumours Details
HER2/Neu GP2 vaccine(Greenwich LifeSciences Inc/NuGenerex Immuno Oncology) GLSI-100 Phase 3 Clinical Antigen Express Inc, Norwell Inc Breast Neoplasms Details
Zanidatamab zovodotin ZW-49 Phase 1 Clinical Zymeworks Inc Neoplasms Details
Recombinant anti-HER2 antibody-Tub114 DAC-001; DX126-262 Phase 2 Clinical Hangzhou Dac Biotech Company Ltd Stomach Neoplasms; Carcinoma, Transitional Cell; Breast Neoplasms; Metastatic breast cancer Details
Runimotamab BTRC-4017A; RG-6194 Phase 1 Clinical F. Hoffmann-La Roche Ltd Solid tumours; Neoplasms Details
MT-5111 MT-5111 Phase 1 Clinical Molecular Templates Solid tumours Details
HER2 cancer vaccine (BioLife Science) PEV-6; PEV-6A; IMU-131 Phase 2 Clinical Pevion Biotech Stomach Neoplasms; Esophageal Neoplasms; Gastrointestinal Neoplasms; Adenocarcinoma Details
Zenocutuzumab MCLA-128 Phase 2 Clinical Merus Solid tumours; Pancreatic Neoplasms; Breast Neoplasms Details
Selatinib Ditosilate QLNC-120 Phase 2 Clinical Qilu Antibiotics (Linyi) Pharmaceutical Co Ltd, Qilu Pharmaceutical Co Ltd Breast Neoplasms Details
HLX-22 AC-101; HLX-22 Phase 2 Clinical Shanghai Henlius Biotech Co Ltd Solid tumours; Stomach Neoplasms; Breast Neoplasms Details
Allitinib Tosylate AST-6; ALS-1306; AST-1306 Phase 2 Clinical Shanghai Allist Pharmaceutical Technology Co Ltd Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details
AMX-3009 Maleate AMX-3009; AMX3009马来酸 Phase 1 Clinical Anrun Medicine Technology (Suzhou) Co Ltd Solid tumours; Stomach Neoplasms; Pancreatic Neoplasms; Breast Neoplasms Details
Trastuzumab biosimilar (Alteogen) ALT-L2; ALT-02; QL-1701 Phase 3 Clinical Alteogen Inc Stomach Neoplasms; Esophageal Neoplasms; Breast Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
MRG-002 MRG-002 Phase 2 Clinical Shanghai Miracogen Inc Biliary Tract Neoplasms; Solid tumours; Stomach Neoplasms; Esophageal Neoplasms; Neoplasms; Carcinoma, Transitional Cell; Breast Neoplasms; Bile Duct Neoplasms; Metastatic breast cancer; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details
BAT-1006 BAT-1006 Phase 1 Clinical Bio-Thera Solutions Ltd Solid tumours Details
Pertuzumab biosimilar(EirGenix) EG-1206A; EG-1206-A Phase 1 Clinical Eirgenix Inc Breast Neoplasms Details
Iodine-131-SGMIB anti-HER2 monoclonal antibody [131I]-SGMIB Anti-HER2-VHH1; 131I-SGMIB-anti-HER2-VHH1; Iodine-131-SGMIB-anti-HER2-VHH1; CAM-H2 Phase 2 Clinical Camel-Ids Stomach Neoplasms; Esophageal Neoplasms; Breast Neoplasms Details
IMM-2902 IMM-2902 Phase 1 Clinical ImmuneOnco Biopharmaceuticals (Shanghai) Co Ltd Solid tumours Details
BC-004 BC-004 Phase 1 Clinical Shandong Buchang Pharmaceuticals Co Ltd Solid tumours; Breast Neoplasms Details
Trastuzumab monomethyl auristatin F FS-1502; LCB14-0110; LCB-14-0110 Phase 2 Clinical Legochembio Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
DB-1303 DB-1303 Phase 2 Clinical Duality Biologics Co Ltd Solid tumours; Neoplasm Metastasis Details
GQ-1005 GQ-1005; GQ1005 Phase 1 Clinical GeneQuantum Healthcare (Suzhou) Co Ltd Neoplasms Details
SHR-A1811 SHR-A1811 Phase 3 Clinical Jiangsu Hengrui Medicine Co Ltd, Suzhou Suncadia Biopharmaceuticals Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd Solid tumours; Stomach Neoplasms; Esophageal Neoplasms; Neoplasms; Breast Neoplasms; Colorectal Neoplasms; HR-positive breast cancer; Metastatic breast cancer; Carcinoma, Non-Small-Cell Lung Details
ARV-471 PF-07850327; ARV-471 Phase 2 Clinical Arvinas Inc Breast Neoplasms Details

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