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Axl

요약

Name:AXL receptor tyrosine kinase
Target Synonym:EC:2.7.10.1,EC 2.7.10,UFO,AXL Transforming Sequence/Gene,AXL Oncogene,EC 2.7.10.1,JTK11,Tyro7,ARK,Tyrosine-protein kinase receptor UFO,AXL,AXL Receptor Tyrosine Kinase
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:28
Lastest Research Phase:Approved

라이센싱

Project Name Modality Therapeutic Area Indications Stage Right Available
AXL inhibitor Small molecule Oncology/Cancer STK11_mut NSCLC,other cancers Phase I Global

제품 리스트 구매

일부의 생물활성 데이터

AXL-H5253-SPR
 Axl SPR

Human Axl, Fc Tag (Cat. No. AXL-H5253) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human GAS6, His Tag (Cat. No. GA6-H5249) with an affinity constant of 1.23 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

AXL-H5226-SPR
 Axl SPR

Human Axl, His Tag (Cat. No. AXL-H5226) immobilized on CM5 Chip can bind Human GAS6, His Tag (Cat. No. GA6-H5249) with an affinity constant of 3.4 nM as determined in SPR assay (Biacore 8K) (QC tested).

Synonym Name

AXL,UFO

Background

AXL Receptor Tyrosine Kinase is also known as Tyrosine-protein kinase receptor UFO, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. AXL contains two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. AXL is highly expressed in metastatic colon tumors. AXL is activated by GAS6-binding and subsequent autophosphorylation. AXL is involved in signal transduction from the extracellular matrix into the cytoplasm by binding growth factors, and thus implicated in the stimulation of cell proliferation.

Clinical and Translational Updates

공개 약품 정보

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Gilteritinib Fumarate ASP-2215 hemifumarate; ASP-2215; 66D-92MGC8M (UNII code) Approved Astellas Pharma Inc Xospata Japan Leukemia, Myeloid, Acute Astellas Pharma Inc 2018-09-21 Solid tumours; Renal Insufficiency; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Cabozantinib S-malate XL-184; BMS-907351; RO7047650; RO-7047650 Approved Exelixis Inc Cometriq, Cabometyx United States Thyroid Neoplasms; Carcinoma, Neuroendocrine Exelixis Inc 2012-11-29 Neuroblastoma; Thyroid Neoplasms; Hepatic Insufficiency; Astrocytoma; Peritoneal Neoplasms; Bile Duct Neoplasms; Colorectal Neoplasms; Gliosarcoma; Urethral Neoplasms; Sarcoma, Clear Cell; Uterine Neoplasms; Cholangiocarcinoma; Neurofibroma, Plexiform; Brain Neoplasms; Adenocarcinoma, Clear Cell; Carcinoma, Adenosquamous; Medullary thyroid cancer (MTC); Sarcoma, Ewing; Sarcoma; Osteosarcoma; Sarcoma, Alveolar Soft Part; Meningioma; Melanoma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Endometrioid; Thyroid Cancer, Papillary; Paraganglioma; Neoplasms, Germ Cell and Embryonal; Carcinoma, Hepatocellular; Prostatic Neoplasms; Glioma; Brain metastases; Endometrial Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Squamous Cell; Lymphoma; Carcinoma, Neuroendocrine; Fallopian Tube Neoplasms; Carcinoma, Renal Cell; Adenoma, Islet Cell; Glioblastoma; Carcinoma, Ovarian Epithelial; Renal Insufficiency; Hepatoblastoma; Pheochromocytoma; Carcinoid Tumor; Carcinoma, Merkel Cell; Rejection of liver transp Details

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
Zanzalintinib XL-092 Phase 3 Clinical Exelixis Inc Solid tumours; Leiomyosarcoma; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Neoplasms; Carcinoma, Transitional Cell; Prostatic Neoplasms, Castration-Resistant; Breast Neoplasms; Colorectal Neoplasms; Uterine Neoplasms; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular Details
KC1036 KC1036; KC-1036 Phase 3 Clinical Beijing Konruns Pharmaceutical Co Ltd Hematologic Neoplasms; Solid tumours; Digestive System Neoplasms; Sarcoma, Ewing; Thymus Neoplasms; Esophageal Squamous Cell Carcinoma; Adenocarcinoma; Neoplasm Metastasis Details
Sitravatinib MGCD-516; IND-155305; MGCD-0516; MG-91516; MG-516 Phase 3 Clinical Mirati Therapeutics Inc Breast Neoplasms; Gastrointestinal Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Carcinoma, Hepatocellular; Endometrial Neoplasms; Lung Neoplasms; Metastatic breast cancer; Esophageal Squamous Cell Carcinoma; Mouth Neoplasms; Carcinoma, Squamous Cell; Hepatic Insufficiency; Ureteral Neoplasms; Solid tumours; Lung Diseases; Liposarcoma; Uveal melanoma; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Neoplasms; Carcinoma; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Kidney Neoplasms; Biliary Tract Neoplasms Details
Ningetinib Tosylate CT-053-PTSA; CT-053 Phase 2 Clinical Hec Pharm Co Ltd Solid tumours; Intestinal Neoplasms; Carcinoma, Renal Cell; Stomach Neoplasms; Leukemia, Myeloid, Acute; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Mecbotamab vedotin BA-3011; BA3011; BA 3011 Phase 2 Clinical Bioatla Ovarian Neoplasms; Dermatofibrosarcoma; Sarcoma; Carcinoma, Non-Small-Cell Lung Details
Merestinib 5OGS5K699E; LY-2801653 Phase 2 Clinical Eli Lilly And Company Biliary Tract Neoplasms; Solid tumours; Skin Melanoma; Bone metastases; Pancreatic Neoplasms; Neoplasms; Microsatellite instability-high cancer; Breast Neoplasms; Cholangiocarcinoma; Lymphoma, Mantle-Cell; Colorectal Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Gallbladder Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
Tamnorzatinib ONO-7475 Phase 2 Clinical Ono Pharmaceutical Co Ltd Leukemia; Solid tumours; Myelodysplastic Syndromes; Pancreatic Neoplasms; Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Non-Small-Cell Lung Details
Bemcentinib BGB-324; R-428; BGB-3234 Phase 2 Clinical Rigel Pharmaceuticals Inc Pancreatic Neoplasms; Coronavirus Disease 2019 (COVID-19); Adenocarcinoma of Lung; Myelodysplastic Syndromes; Inflammatory Breast Neoplasms; Triple Negative Breast Neoplasms; Glioblastoma; Central Nervous System Neoplasms; Mesothelioma; Brain Neoplasms; Leukemia, Myeloid, Acute; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma Details
Enapotamab vedotin AXL-107-MMAE Phase 2 Clinical Seagen Inc, Genmab A/S Solid tumours; Ovarian Neoplasms; Sarcoma; Endometrial Neoplasms; Thyroid Neoplasms; Melanoma; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung Details
FC-084-CSA FC084CSA; FC-084-CSA Phase 2 Clinical FindCure Biosciences (ZhongShan) Co Ltd Solid tumours Details
XZB-0004 XZB-0004; SLC-0211; SLC-391 Phase 2 Clinical Xuanzhu (Shijiazhuang) Biotechnology Co Ltd Solid tumours; Hematologic Neoplasms; Myelodysplastic Syndromes; Leukemia, Myeloid, Acute; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Foodborne Diseases Details
Butylidenephthalide NSC-325307; LF-001 (Everfront Biotech); EF-001; HK-001; BDPH Phase 2 Clinical Everfront Biotech Co Ltd Glioblastoma; Glioma; Amyotrophic Lateral Sclerosis Details
Adrixetinib Q-702 Phase 2 Clinical Vichem Chemie, Max Planck Institute of Biochemistry, Lead Discovery Center GmbH Lymphoma, Follicular; Central Nervous System Lymphoma; Uterine Cervical Neoplasms; Carcinoma, Hepatocellular; Neoplasm Metastasis; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma; Leukemia, Myeloid, Acute; Lymphoma, T-Cell, Cutaneous; Waldenstrom Macroglobulinemia; Primary Myelofibrosis; Histiocytic Sarcoma; Erdheim-Chester Disease; Hematologic Neoplasms; Histiocytosis, Langerhans-Cell; Histiocytosis, Sinus; Neoplasms; Graft vs Host Disease; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Stomach Neoplasms; Esophageal Neoplasms; Leukemia, Lymphoid; Solid tumours; Lymphoma, T-Cell, Peripheral Details
Dubermatinib TP-0903 Phase 1 Clinical Sumitomo Dainippon Solid tumours; Ovarian Neoplasms; Colorectal Neoplasms; Leukemia, Myeloid, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Carcinoma, Non-Small-Cell Lung; Melanoma Details
INCB-081776 INCB-81776; INCB-081776 Phase 1 Clinical Incyte Corp Solid tumours; Squamous Cell Carcinoma of Head and Neck Details
BPI-9016 BPI-9016; BPI-9016M Phase 1 Clinical Betta Pharmaceuticals Co Ltd Solid tumours; Carcinoma, Non-Small-Cell Lung Details
Mipasetamab uzoptirine ADCT-601; BGB-601; 1H12-GaINAcN3; 1H12-HAKB Phase 1 Clinical Adc Therapeutics Sa Solid tumours Details
NP-01 (SSY Group) Phase 1 Clinical Solid tumours; Liver Neoplasms; Stomach Neoplasms; Prostatic Neoplasms; Lung Neoplasms Details
A-416 A416; A-416 Phase 1 Clinical Klus Pharma Inc Solid tumours Details
NTQ-2494 NTQ2494; NTQ-2494 Phase 1 Clinical Nanjing Zhengda Tianqing Pharmaceutical Co Ltd Solid tumours; Hematologic Neoplasms; Leukemia, Myeloid, Acute Details
CTS-2016 CTS-2016 Phase 1 Clinical CytosinLab Therapeutics Co Ltd Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
AB-801 AB-801 Phase 1 Clinical Arcus Biosciences Inc Neoplasms Details
NP-107 NP107; NP-107 Phase 1 Clinical Shanghai Nawei Biotechnology Co Ltd Solid tumours Details
TT-00973 TT-00973 Phase 1 Clinical TransThera Sciences (Nanjing) Inc Solid tumours Details
AGX-0073 AGX-0073 Phase 1 Clinical Shanghai Aojian Biological Technology Co Ltd Solid tumours Details
PF-07265807 PF-07265807 Phase 1 Clinical Pfizer Inc Solid tumours; Neoplasm Metastasis Details
Denfivontinib Hydrochloride SKI-G-801; G-801; G-749 Hydrochloride Phase 1 Clinical Genosco Solid tumours; Leukemia, Myeloid, Acute Details
NP-01 (Shijiazhuang No.4 Pharmaceutical/Nanjing Nadingfei Medical Technology) NP-01 Phase 1 Clinical Shijiazhuang No 4 Pharmaceutical Co Ltd, Nanjing Nadingfei Pharmaceutical Technology Co Ltd Liver Neoplasms; Solid tumours; Stomach Neoplasms; Lung Neoplasms Details
NPS-1034 HOPE-777; KDDF-201111-02 Neopharma Ltd Details
cancer therapeutics (BerGenBio) BGB-101; BGB-109; BGB-003; BGB-001 Bergenbio Details

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