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Your Position: > Integrin alpha 3 beta 1

Integrin alpha 3 beta 1

요약

Name:Integrin alpha 3/beta 1
Target Synonym:
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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제품번호 제품 설명 구조 순도 특징
IT1-H52Wc Human Human Integrin alpha 3 beta 1 (ITGA3&ITGB1) Heterodimer Protein, His Tag&Tag Free (MALS verified)
IT1-H52Wc-structure
IT1-H52Wc-sds

일부의 생물활성 데이터

IT1-H52Wc-MALS-HPLC
Human ITGA3&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. ) MALS images

The purity of Human ITGA3&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52Wc) is more than 85% and the molecular weight of this protein is around 229-279 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human ITGA3&ITGB1 Heterodimer Protein, His Tag&Tag FreeHuman ITGA3&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52Wc) ELISA bioactivity

Immobilized Human ITGA3&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52Wc) at 5 μg/mL (100 μL/well) can bind Human Laminin 511 E8, Fc Tag (Cat. No. LA8-H5283) with a linear range of 0.1-8 ng/mL (QC tested).

IT1-H52Wc-ELISA
Human ITGA3&ITGB1 Heterodimer Protein, His Tag&Tag FreeHuman ITGA3&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52Wc) ELISA bioactivity

Immobilized Human ITGA3&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52Wc) at 5 μg/mL (100 μL/well) can bind Human Laminin 511 E8, Fc Tag (Cat. No. LA8-H5283) with a linear range of 0.1-8 ng/mL (QC tested).

Synonym Name

Integrin alpha 3 beta 1,ITGA3&ITGB1

Background

Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.

Clinical and Translational Updates

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
VAX-014 VAX-014 Phase 1 Clinical Vaxiion Therapeutics Solid tumours Details

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