로그인 회원가입
icon_bulk_order대량 주문 조회 Acrobiosystems for English
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: > LRP-5

LRP-5

제품 리스트 비교 또는 구매

일부의 생물활성 데이터

LR5-H82E6-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Biotinylated Human LRP-5, His,Avitag (Cat. No. LR5-H82E6) on SA Biosensor, can bind Human SOST, His Tag (Cat. No. HST-H5245) with an affinity constant of 7.4 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

LR5-H82E6-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Biotinylated Human LRP-5, His,Avitag (Cat. No. LR5-H82E6) on SA Biosensor, can bind Human Dkk-1, His Tag (Cat. No. DK1-H5221) with an affinity constant of 93.1 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

LRP5,LRP-5,LRP-7,LRP7,LR3

Background

Low-density lipoprotein receptor-related protein 5(LRP-5) is also known as  BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPTA1, VBCH2, LDL receptor related protein 5 and PCLD4. LRP5 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP6. LRP5 acts as a co-receptor with LRP6 and the Frizzled protein family members for transducing signals by Wnt proteins through the canonical Wnt pathway. This protein plays a key role in skeletal homeostasis. Mutations in LRP5 can lead to considerable changes in bone mass. A loss-of-function mutation causes osteoporosis-pseudoglioma (decrease in bone mass), while a gain-of-function mutation causes drastic increases in bone mass.

Clinical and Translational Updates

This web search service is supported by Google Inc.

totop