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Properdin

요약

Name:Properdin
Target Synonym:Complement factor P,CFP
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

제품 리스트 구매

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제품 유형별 :
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결합물별:
제품번호 제품 설명 구조 순도 특징
PRN-R52H6 Rhesus macaque Rhesus macaque Properdin Protein, His Tag
PRN-R52H6-structure
PRN-R52H6-sds
PRN-M52H5 Mouse Mouse Properdin Protein, His Tag
PRN-M52H5-structure
PRN-M52H5-sds
PRN-H52H3 Human Human Properdin Protein, His Tag
PRN-H52H3-structure
PRN-H52H3-sds

Synonym Name

Properdin,Complement factor P,CFP,PFC

Background

Properdin is also known as Complement factor P, CFP, PFC, a positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Properdin is produced by many different leukocyte subsets and circulates as cyclic oligomers of monomeric subunits. Properdin on platelet/granulocyte aggregates(PGA) formation are tightly regulated by Factor H, properdin enhances PGA formation via increased production of C5a, and that inhibition of properdin function has therapeutic potential to limit thromboinflammation in diseases characterized by increased PGA formation.

Clinical and Translational Updates

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
Tarperprumig ALXN-1820 Phase 2 Clinical Alexion Pharmaceuticals Inc Anemia, Sickle Cell Details

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