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PDGF-BB

요약

Name:Platelet-derived growth factor subunit B
Target Synonym:Epididymis Secretory Sperm Binding Protein,Becaplermin,PDGF-2,PDGFB,Platelet Derived Growth Factor Subunit B,Platelet-Derived Growth Factor Beta Polypeptide (Simian Sarcoma Viral (V-Sis) Oncogene Homolog),Platelet-Derived Growth Factor B Chain,Proto-Oncogene C-Sis,PDGF Subunit B,PDGF2,SIS,Platelet-Derived Growth Factor Subunit B,Platelet-Derived Growth Factor 2,PDGF, B Chain,Oncogene SIS,IBGC5,C-Sis,SSV,Platelet-Derived Growth Factor Beta Polypeptide,Platelet-Derived Growth Factor, Beta Polypept
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 2 Clinical

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제품번호 제품 설명 구조 순도 특징
PDB-H4112 Human Human PDGF-BB Protein, premium grade
PDB-H4112-structure
PDB-H4112-sds
PDB-H5127 Human Unconjugated Human PDGF-BB Protein, His,Avitag™
PDB-H5127-structure
PDB-H5127-sds

일부의 생물활성 데이터

PDB-H4112-Cell-based assay
 PDGF-BB CELL

The bio-activity was determined by dose-dependent stimulation of the proliferation of mouse 3T3 cells. The ED50 was 0.5-20 ng/mL (Routinely tested).

PDB-H5127-ELISA
Unconjugated Human PDGF-BB, His,AvitagUnconjugated Human PDGF-BB, His,Avitag (Cat. No. PDB-H5127) ELISA bioactivity

Immobilized Unconjugated Human PDGF-BB, His,Avitag (Cat. No. PDB-H5127) at 1 μg/mL (100 μL/well) can bind Human PDGF R beta, Fc Tag (Cat. No. PDB-H5259) with a linear range of 0.5-16 ng/mL (QC tested).

PDB-H4112-ELISA
 PDGF-BB ELISA

Immobilized Human PDGF-BB, premium grade (Cat. No. PDB-H4112) at 1 μg/mL (100 μL/well) can bind Human PDGF R beta, Fc Tag (Cat. No. PDB-H5259) with a linear range of 0.6-10 ng/mL (QC tested).

Synonym Name

PDGF-BB,PDGF-B,FLJ12858,PDGF2,SIS,SSV,c-sis

Background

PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. Platelet-derived growth factor subunit B is also known as PDGFB, FLJ12858, PDGF2, SIS, SSV, c-sis, is a member of the platelet-derived growth factor family. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.

Clinical and Translational Updates

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
HL-217 HL-217; KR-31831 Phase 1 Clinical Korea Research Institute Of Chemical Technology (Krict) Macular Degeneration Details
Ilorasertib ABT-348; A-9686600; Abbott-968660 Abbvie Inc Details
DE-120 DE-120 Santen Details
Pegpleranib Sodium X-01E; OAP-030; E-01AJ; DD50D2QKH1 (UNII code); E-10030 Archemix, Osi Pharmaceutical Details
Squalamine OHR-102; MSI-1256F Genaera Details
XL-820 XL-820 Exelixis Details
KUR-212 KUR-212; I-020502 Kuros Biosciences Details
SHP-627 FT-11; FT-001; FT-011; SHP-627 Phase 2 Clinical Shire Pharmaceuticals Scleroderma, Systemic; Scleroderma, Diffuse Details

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