Immobilized Human Collagen IV at 2 μg/mL (100 μL/well) can bind Mouse ITGA2&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-M52W3) with a linear range of 0.02-0.625 μg/mL (QC tested).
The purity of Mouse ITGA2&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-M52W3) is more than 90% and the molecular weight of this protein is around 210-240 kDa verified by SEC-MALS.
Immobilized Human Collagen IV at 2 μg/mL (100 μL/well) can bind Mouse ITGA2&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-M52W3) with a linear range of 0.02-0.625 μg/mL (QC tested).
Synonym Name
Integrin alpha 2 beta 1,ITGA2 & ITGB1
Background
Integrin alpha 2 beta 1 is one of twelve integrin family adhesion receptors that share the beta 1 subunit. It is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A and Human echoviruses 1 and 8. DGEA inhibited rotavirus binding to alpha2beta1 and infectivity. In a novel process, integrin-using viruses bind the alpha2 I domain of alpha2beta1 via DGE in VP4 and interact with alphaXbeta2 (via GPR) and alphaVbeta3 by using VP7 to facilitate cell entry and infection.