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TrkA

요약

Name:Nerve growth factor receptor Trk-A
Target Synonym:NTRK1,Neurotrophic tyrosine kinase receptor type 1,TRK1-transforming tyrosine kinase protein,Tyrosine kinase receptor A,TRKA,Trk-A,Tyrosine kinase receptor,EC:2.7.10.1,High Affinity Nerve Growth Factor Receptor,EC 2.7.10,Neurotrophic Receptor Tyrosine Kinase 1,Neurotrophic Tyrosine Kinase, Receptor, Type 1,Tropomyosin-Related Kinase A,P140-TrkA,Gp140trk,MTC,TRK,Oncogene TRK,EC 2.7.10.1,TRK1,Receptor, trkA
Number of Launched Drugs:4
Number of Drugs in Clinical Trials:24
Lastest Research Phase:Approved

제품 리스트 구매

Synonym Name

TrkA,NTRK1,MTC,TRK,TRKA,Trk-A

Background

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand. Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.

Clinical and Translational Updates

공개 약품 정보

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Entrectinib NMS-E628; RXDX-101; RG-6268 Approved Nerviano Medical Sciences Srl Rozlytrek, 罗圣全 Japan Carcinoma, Non-Small-Cell Lung Chugai Pharmaceutical Co Ltd 2019-06-18 Breast Neoplasms; Thyroid Cancer, Papillary; Melanoma; Carcinoma, Non-Small-Cell Lung; Glioma; Lymphoma, Large-Cell, Anaplastic; Leukemia, Myeloid, Acute; Hepatic Insufficiency; Lymphoproliferative Disorders; Colorectal Neoplasms; Sarcoma; Brain Neoplasms; Ovarian Neoplasms; Cholangiocarcinoma; Neuroendocrine Tumors; Central Nervous System Neoplasms; Neoplasms; Salivary Gland Neoplasms; Pancreatic Neoplasms; Carcinoma, Renal Cell; Hematologic Neoplasms; Head and Neck Neoplasms; Solid tumours Details
Regorafenib DAST; BAY-73-4506 Approved Bayer AG Stivarga, Resihance United States Colorectal Neoplasms Bayer Healthcare Pharmaceuticals Inc 2012-09-27 Leukemia, Myeloid, Acute; Sarcoma, Ewing; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Bone Neoplasms; Peritoneal Neoplasms; Bile Duct Neoplasms; Esophageal adenocarcinoma; Lung Neoplasms; Thyroid Neoplasms; Fallopian Tube Neoplasms; Osteosarcoma; Thymoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Neoplasm Metastasis; Adenocarcinoma; Somatostatinoma; Gastrointestinal Neoplasms; Melanoma; Meningioma; Neoplasms; Solid tumours; Liver Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Insulinoma; Carcinoma, Islet Cell; Hemangiosarcoma; Rectal Neoplasms; Carcinoma, Renal Cell; Ovarian Neoplasms; Colonic Neoplasms; Carcinoma, Ovarian Epithelial; Pancreatic Neoplasms; Carcinoma, Transitional Cell; Adenoma; Glucagonoma; Carcinoma, Adenoid Cystic; Gastrinoma; Sarcoma Details
Larotrectinib sulfate LOXO-101; ARRY-470; BAY-2757556 Approved Array Biopharma Vitrakvi, 维泰凯 United States Solid tumours Bayer Healthcare Pharmaceuticals Inc 2018-11-26 Glioma; Multiple Myeloma; Urinary Bladder Neoplasms; Histiocytosis, Langerhans-Cell; Osteosarcoma; Sarcoma, Ewing; Neuroblastoma; Sarcoma; Prostatic Neoplasms; Breast Neoplasms; Histiocytic Sarcoma; Colorectal Neoplasms; Carcinoma, Squamous Cell; Central Nervous System Neoplasms; Thyroid Neoplasms; Lymphoma, Non-Hodgkin; Lymphoma; Lung Neoplasms; Uterine Neoplasms; Endometrial Neoplasms; Xanthogranuloma, Juvenile; Neuroectodermal Tumors, Primitive, Peripheral; Neoplasms, Germ Cell and Embryonal; Melanoma; Uterine Cervical Neoplasms; Squamous Cell Carcinoma of Head and Neck; Solid tumours; Ependymoma; Fibrosarcoma; Rhabdomyosarcoma; Medulloblastoma; Leukemia; Ovarian Neoplasms; Liver Neoplasms; Head and Neck Neoplasms; Rhabdoid Tumor; Hepatoblastoma; Hematologic Neoplasms; Carcinoma, Renal Cell; Esophageal Neoplasms; Stomach Neoplasms; Rectal Neoplasms; Neoplasms; Wilms Tumor; Carcinoma, Transitional Cell; Pancreatic Neoplasms; Carcinoma, Ovarian Epithelial; Skin Neoplasms; Colonic Neoplasms Details
Repotrectinib BMS-986472; ZL-2308; TPX-0005 Approved Turning Point Therapeutics Inc 奥凯乐, Augtyro United States Carcinoma, Non-Small-Cell Lung Bristol-Myers Squibb Company 2023-11-15 Solid tumours; Neoplasms; Central Nervous System Neoplasms; Hepatic Insufficiency; Lymphoma; Brain metastases; Carcinoma, Non-Small-Cell Lung Details

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
Tavilermide MIM-D3; NMG938VJ6T (UNII code) Phase 3 Clinical Mimetogen Pharmaceuticals Keratoconjunctivitis Sicca; Dry Eye Syndromes Details
Lestaurtinib SPM-924; A-154475.0; KT-5555; SP-924; CEP-701 Phase 3 Clinical Kyowa Hakko Kirin Co Ltd Leukemia; Leukemia, Myeloid; Bone Marrow Neoplasms; Polycythemia Vera; Prostatic Neoplasms; Neuroblastoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psoriasis; Primary Myelofibrosis; Leukemia, Myeloid, Acute; Thrombocythemia, Essential Details
VC-004 VC004; VC-004; VC 004 Phase 3 Clinical Jiangsu Vcare Pharmatech Co Ltd Solid tumours; Cancer Pain; Pruritus; Dermatitis Details
SNA-125 CT-340; SNA-125 Phase 2 Clinical Sienna Biopharmaceuticals Inc, Creabilis Sa Pruritus; Psoriasis; Dermatitis, Atopic Details
Merestinib 5OGS5K699E; LY-2801653 Phase 2 Clinical Eli Lilly And Company Biliary Tract Neoplasms; Solid tumours; Skin Melanoma; Bone metastases; Pancreatic Neoplasms; Neoplasms; Microsatellite instability-high cancer; Breast Neoplasms; Cholangiocarcinoma; Lymphoma, Mantle-Cell; Colorectal Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Gallbladder Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
Milciclib maleate PHA-848125; TZLS-201; PHA-848125C; PHA-125; PHA-848125AC Phase 2 Clinical Tiziana Life Sciences Plc, Nerviano Medical Sciences Srl Solid tumours; Thymoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung Details
FCN-011 FCN-011 Phase 2 Clinical Fochon Pharmaceuticals Ltd Solid tumours Details
AK-1830 AK-1830; ARRY-954 Phase 2 Clinical Array Biopharma Low Back Pain Details
XZP-5955 XZP-5955 Phase 2 Clinical Xuanzhu (Shijiazhuang) Biotechnology Co Ltd Solid tumours; Carcinoma, Non-Small-Cell Lung Details
BEN-2293 BEN-00002293; BEN-2293 Phase 2 Clinical Benevolentai Bio Ltd Dermatitis, Atopic Details
TQB-3558 TQB-3558; CT-3417 Phase 1 Clinical Beijing Centaurus Biopharma Co Ltd, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd Solid tumours Details
BPI-28592 BPI-28592 Phase 1 Clinical Betta Pharmaceuticals Co Ltd Solid tumours; Neoplasm Metastasis Details
ACD-856 ACD-856 Phase 1 Clinical Alzecure Pharma Ab Alzheimer Disease; Cognition Disorders Details
HG-030 HG-030 Phase 1 Clinical Hitgen Inc Solid tumours Details
STSP-0902 STSP-0902; STSP0902 Phase 1 Clinical Staidson(Beijing) Biopharmaceuticals Co Ltd Keratitis; Oligospermia; Asthenozoospermia Details
BR-01T BR01T; BR-01T Phase 1 Clinical Xiyuan Anjian Pharmaceutical (Shanghai) Co Ltd Low Back Pain Details
ND-003 (NewDEL Biotech) ND003 (NewDEL Biotech); ND-003 (NewDEL Biotech) Phase 1 Clinical Shenzhen NewDEL Biotech Co Ltd Solid tumours; Idiopathic Pulmonary Fibrosis; Neoplasms; Renal fibrosis; Pulmonary Fibrosis; Gastrointestinal Stromal Tumors; Renal Insufficiency, Chronic; Dermatitis, Atopic Details
HT006.2.2 HT006.2.2; HT-006.2.2 Phase 1 Clinical Wuhan Hiteck Biological Pharma Co Ltd Keratitis Details
JND-5932 JND-5932; JND5932 Phase 1 Clinical Jinan University Neoplasms Details
PBI-200 PBI-200 Phase 1 Clinical Pyramid Biosciences Solid tumours; Desmoplastic Small Round Cell Tumor; Brain Neoplasms Details
FCN-098 FCN-098; FCN098 Phase 1 Clinical Fochon Pharmaceuticals Ltd, Fochon Pharmaceuticals Ltd Solid tumours; Neoplasms Details
E-2511 E2511; E-2511 Phase 1 Clinical Eisai Inc Details
VMD-928 VMD-928 Phase 1 Clinical Vm Oncology Llc Urinary Bladder Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Uterine Neoplasms; Lung Neoplasms; Appendiceal Neoplasms; Thymoma; Sarcoma; Breast Neoplasms; Ovarian Neoplasms; Carcinoma, Adenoid Cystic; Mesothelioma; Pancreatic Neoplasms; Esophageal Neoplasms; Esthesioneuroblastoma, Olfactory; Solid tumours; Head and Neck Neoplasms Details

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