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TPBG

요약

Name:Trophoblast glycoprotein
Target Synonym:Trophoblast glycoprotein,5T4 oncotrophoblast glycoprotein,5T4,TPBG,5T4 oncofetal antigen,M6P1,5T4 oncofetal trophoblast glycoprotein,Wnt-Activated Inhibitory Factor 1,WAIF1,5T4AG,5T4-AG
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:6
Lastest Research Phase:Phase 1 Clinical

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일부의 생물활성 데이터

TPG-H5253-ELISA
Human TPBG, Fc TagHuman TPBG, Fc Tag (Cat. No. TPG-H5253) ELISA bioactivity

Immobilized Human TPBG, Fc Tag (Cat. No. TPG-H5253) at 1 μg/mL (100 μL/well) can bind Anti-TPBG Antibody, Human IgG1 with a linear range of 0.5-8 ng/mL (QC tested).

TPG-M52H3-MALS-HPLC
Mouse TPBG, His Tag (Cat. No. ) MALS images

The purity of Mouse TPBG, His Tag (Cat. No. TPG-M52H3) is more than 90% and the molecular weight of this protein is around 53-65 kDa verified by SEC-MALS.

  • Background
    Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues.This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. TPBG is expressed by all types of trophoblasts as early as 9 weeks of development.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

Synonym Name

TPBG,5T4,M6P1,5T4AG,WAIF1,5T4 oncofetal antigen,Trophoblast glycoprotein,5T4 oncofetal trophoblast glycoprotein

Background

Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues.This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. TPBG is expressed by all types of trophoblasts as early as 9 weeks of development.

Clinical and Translational Updates

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
Prostate cancer vaccine(inactivated viral)(University of Oxford) Clinical University Of Oxford Prostatic Neoplasms Details
OXB-301 OXB-301; SAR-109659 Oxford Biomedica Details
ASN-004 ASN-004 Asana Biosciences Details
SYD-1875 SYD-1875 Synthon Bv Details
PF-06263507 PF-06263507 Oxford Biomedica Details
Naptumomab estafenatox TTS-CD3; ABR-217620 Active Biotech Details
Anti-5T4 CAR-raNK Cell Therapy Phase 1 Clinical Imbioray (Hangzhou) Biomedicine Co Ltd Solid tumours Details

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