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BAFFR

요약

Name:B-cell activating factor receptor
Target Synonym:BAFFR,B Cell-Activating Factor Receptor,Prolixin,BROMIX,CD268,Tumor Necrosis Factor Receptor Superfamily, Member 13C,Tumor Necrosis Factor Receptor Superfamily Member 13C,BR3,CVID4,CD268 Antigen,BAFF Receptor,B-Cell Activation Factor Receptor,BAFF-R,TNF Receptor Superfamily Member 13C,BLyS Receptor 3,B-Cell-Activating Factor Receptor,TNFRSF13C
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 3 Clinical

라이센싱

항목 적응증 연구 단계 합작 수요
BIA202201 B cell malignancies/ autoimmune diseases Ready for CMC development License-out or co-development

제품 리스트 비교 또는 구매

일부의 생물활성 데이터

BAR-H5258-SPR
Human_FcRn_Heterodimer_Protein_SPR

Immobilized Human BAFF, Fc Tag, active trimer (Cat. No. BAF-H5261) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human BAFFR, Llama IgG2b Fc Tag, low endotoxin (Cat. No. BAR-H5258) with an affinity constant of 44.5 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

BAR-H5257-SPR
Human_FcRn_Heterodimer_Protein_SPR

Immobilized Biotinylated Human BAFF, Avitag,Fc Tag (active trimer) (MALS verified) (Cat. No. BAF-H82F3) on SA Chip can bind Human BAFFR, Fc Tag (Cat. No. BAR-H5257) with an affinity constant of 26.7 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Synonym Name

BAFFR,TNFRSF13C,BROMIX,CD268,CVID4,prolixin,BAFF-R

Background

BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.

Clinical and Translational Updates

Related Molecule

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
AUR-200 AUR-200 Phase 1 Clinical Thunderbolt Pharma Inc Autoimmune Diseases Details
ESG-206 ESG-206 Shanghai Escugen Biotechnology Co Ltd Details
Ianalumab VAY-736; NOV-5 Phase 3 Clinical Morphosys Ag, Novartis Pharma Ag Hematologic Neoplasms; Idiopathic Pulmonary Fibrosis; Sjogren's Syndrome; Arthritis, Rheumatoid; Lupus Nephritis; Multiple Sclerosis; Lupus Erythematosus, Systemic; Hepatitis, Autoimmune; Lymphoma, Non-Hodgkin; Pemphigus; Leukemia, Lymphocytic, Chronic, B-Cell Details

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