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Your Position: 홈 > BAFFR

BAFFR

요약

Name:B-cell activating factor receptor
Target Synonym:BAFFR,B Cell-Activating Factor Receptor,Prolixin,BROMIX,CD268,Tumor Necrosis Factor Receptor Superfamily, Member 13C,Tumor Necrosis Factor Receptor Superfamily Member 13C,BR3,CVID4,CD268 Antigen,BAFF Receptor,B-Cell Activation Factor Receptor,BAFF-R,TNF Receptor Superfamily Member 13C,BLyS Receptor 3,B-Cell-Activating Factor Receptor,TNFRSF13C
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Phase 3 Clinical

Antibody Licensing

Project Name Project Stage Molecule Type Host Species Therapeutic Area Indications
BAFFR&CD3 BsAb - 01 PCC Hematological Malignancy,AutoImmunity Blood tumor,Autoimmune disease

제품 리스트 구매

제품> 결과 필터링
제품 상태별:
제품 유형별 :
종별:
태그별:
결합물별:
제품번호 종 제품 설명 구조 순도 특징
BAR-HP2H6 Human PE-Labeled Human BAFFR / TNFRSF13C Protein, His Tag (Site-specific conjugation)
BAR-HP2H6-structure
EP-119 Human BAFFR [Biotinylated] : BAFF Inhibitor Screening ELISA Kit
BAR-M52H8 Mouse Mouse BAFFR / TNFRSF13C Protein, His Tag
BAR-M52H8-structure
BAR-M52H8-sds
BAR-R52H3 Rat Rat BAFFR / TNFRSF13C Protein, His Tag
BAR-R52H3-structure
BAR-R52H3-sds
BAR-C52H4 Cynomolgus Cynomolgus BAFFR / TNFRSF13C Protein, His Tag
BAR-C52H4-structure
BAR-C52H4-sds
BAR-H52H3 Human Human BAFFR / TNFRSF13C Protein, His Tag
BAR-H52H3-structure
BAR-H52H3-sds
BAR-H82E3 Human Biotinylated Human BAFFR / TNFRSF13C Protein, His,Avitag™ (MALS verified)
BAR-H82E3-structure
BAR-H82E3-sds
BAR-H5258 Human Human BAFFR / TNFRSF13C Protein, Llama IgG2b Fc Tag, low endotoxin
BAR-H5258-structure
BAR-H5258-sds
BAR-H5257 Human Human BAFFR / TNFRSF13C Protein, Fc Tag
BAR-H5257-structure
BAR-H5257-sds
BAR-M5259 Mouse Mouse BAFFR / TNFRSF13C Protein, Fc Tag (HPLC verified)
BAR-M5259-structure
BAR-M5259-sds
BAR-M5259-hplc
BAR-M82F0 Mouse Biotinylated Mouse BAFFR / TNFRSF13C Protein, Fc,Avitag™
BAR-M82F0-structure
BAR-M82F0-sds

일부의 생물활성 데이터

BAR-HP2H6-Cell-based assay
BAFFR FACS

5e5 of anti-BAFFR CAR-293 cells were stained with 100 μL of 1:25 dilution (4 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human BAFFR Protein, His Tag (Cat. No. BAR-HP2H6) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).

Protocol
BAR-H5258-SPR
BAFFR SPR

Immobilized Human BAFF Protein, Fc Tag (Cat. No. BAF-H5261) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human BAFFR Protein, Llama IgG2b Fc Tag (Cat. No. BAR-H5258) with an affinity constant of 44.5 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol
BAR-H5257-SPR
BAFFR SPR

Immobilized Biotinylated Human BAFF, Avitag,Fc Tag (active trimer) (MALS verified) (Cat. No. BAF-H82F3) on SA Chip can bind Human BAFFR, Fc Tag (Cat. No. BAR-H5257) with an affinity constant of 26.7 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

사용자 리뷰

Synonym Name

BAFFR,TNFRSF13C,BROMIX,CD268,CVID4,prolixin,BAFF-R

Background

BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.

Clinical and Translational Updates

Related Molecule

BAFF

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
Ianalumab NOV-5; VAY-736 Phase 3 Clinical Morphosys Ag, Novartis Pharma Ag Anemia, Hemolytic, Autoimmune; Pemphigus; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Thrombocytopenia; Hepatitis, Autoimmune; Primary mediastinal B cell lymphoma; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Purpura, Thrombocytopenic, Idiopathic; Lupus Erythematosus, Systemic; Multiple Sclerosis; Lupus Nephritis; Idiopathic Pulmonary Fibrosis; Arthritis, Rheumatoid; Sjogren's Syndrome; Hematologic Neoplasms; Lymphoma, B-Cell, Marginal Zone Details
CD19-BAFF Targeted CAR T-cells Therapy(YaKe Biotechnology) Phase 1 Clinical Shanghai YaKe Biotechnology Co Ltd, Zhejiang University Lymphoma, B-Cell; Autoimmune Diseases Details
ESG-206 ESG-206 Phase 1 Clinical Shanghai Escugen Biotechnology Co Ltd Lymphoma, B-Cell; Neoplasms; Lymphoma Details
AUR-200 AUR-200; AUR200 Phase 1 Clinical Thunderbolt Pharma Inc Autoimmune Diseases Details
BAFFR-CAR T cell therapy (PeproMene Bio Inc) PMB-CT01; PMB-101 Phase 1 Clinical PeproMene Bio Inc, City Of Hope National Medical Center Lymphoma, B-Cell; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Biphenotypic, Acute Details

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