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Integrin alpha V beta 8

제품 리스트 비교 또는 구매

일부의 생물활성 데이터

IT8-C52W9-ELISA
Cynomolgus ITGAV&ITGB8 Heterodimer Protein, His Tag&Tag FreeCynomolgus ITGAV&ITGB8 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT8-C52W9) ELISA bioactivity

Immobilized Cynomolgus ITGAV&ITGB8 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT8-C52W9) at 5 μg/mL (100 μL/well) can bind Biotinylated Human Latent TGF-Beta 1, His,Avitag (Cat. No. TG1-H82Qb) with a linear range of 0.5-16 ng/mL (QC tested).

IT8-M52W6-MALS-HPLC
Mouse ITGAV&ITGB8 Heterodimer Protein, His Tag&Tag Free (Cat. No. ) MALS images

The purity of Mouse ITGAV&ITGB8 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT8-M52W6) is more than 85% and the molecular weight of this protein is around 189-231 kDa verified by SEC-MALS.

Bioactivity-ELISA
Mouse ITGAV&ITGB8 Heterodimer Protein, His Tag&Tag FreeMouse ITGAV&ITGB8 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT8-M52W6) ELISA bioactivity

Immobilized Mouse ITGAV&ITGB8 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT8-M52W6) at 5 μg/mL (100 μL/well) can bind Biotinylated Human Latent TGF-Beta 1, His,Avitag (Cat. No. TG1-H82Qb) with a linear range of 1-10 ng/mL (QC tested).

Synonym Name

Integrin alpha V beta 8,ITGAV&ITGB8

Background

Integrin alpha V beta 8 (ITGAV & ITGB8 or ITGAVB8) is expressed in yolk sac, placenta, brain perivascular astrocytes, Schwann cells, renal glomerular mesangial cells and pulmonary epithelial cells. Unlike other alpha V integrins, ITGAVB8 does not appear to assume different activation states, and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif, including vitronectin, fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP, which releases active TGF-beta. This mechanism differs from that of alpha V beta 6, the other alpha V integrin which can activate TGF-beta from latency through non-proteolytic mechanisms. Downstream effects of TGF-beta activation include control of cell growth and associated vascularization.

Clinical and Translational Updates

Related Molecule

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