로그인 회원가입
icon_bulk_order대량 주문 조회 Acrobiosystems for English
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: > ICOS

ICOS

요약

Name:Inducible T-cell costimulator
Target Synonym:Activation-inducible lymphocyte immunomediatory molecule,Inducible T-cell costimulator,ICOS,CD278,AILIM,Inducible T Cell Costimulator,Inducible T-Cell Co-Stimulator,Inducible Costimulator,CD278 Antigen,CVID1,Inducible T-Cell Co-Stimulator Protein
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:6
Lastest Research Phase:Phase 2 Clinical

제품 리스트 비교 또는 구매

일부의 생물활성 데이터

ICS-M5259-ELISA
Mouse ICOS (C137S, C138S), Fc TagMouse ICOS (C137S, C138S), Fc Tag (Cat. No. ICS-M5259) ELISA bioactivity

Immobilized Human B7-H2, His Tag (Cat. No. B72-H5221) at 1 μg/mL (100 μL/well) can bind Mouse ICOS (C137S, C138S), Fc Tag (Cat. No. ICS-M5259) with a linear range of 0.3-10 ng/mL (QC tested).

ICS-H52H9-MALS-HPLC
Human ICOS (C136S, C137S), His Tag (Cat. No. ) MALS images

The purity of Human ICOS (C136S, C137S), His Tag (Cat. No. ICS-H52H9) is more than 90% and the molecular weight of this protein is around 19-29 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human ICOS (C136S, C137S), His TagHuman ICOS (C136S, C137S), His Tag (Cat. No. ICS-H52H9) ELISA bioactivity

Immobilized Human B7-H2, Fc Tag (Cat. No. B72-H5254) at 1 μg/mL (100 μL/well) can bind Human ICOS (C136S, C137S), His Tag (Cat. No. ICS-H52H9) with a linear range of 0.02-0.313 μg/mL (QC tested).

Synonym Name

ICOS,CD278,AILIM,Inducible T-cell costimulator

Background

Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.

Clinical and Translational Updates

Related Molecule

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
Anti-ICOS (Bristol Myers Squibb) BMS-986226 Phase 1 Clinical Neoplasms Details
Izuralimab XmAb-23104; XmAb-104 Xencor Details
MEDI-570 Phase 1 Clinical Japan Tobacco (Hong Kong) Ltd Lymphoma, Follicular; Lymphoma, T-Cell; Lymphoma, Non-Hodgkin; Mycosis Fungoides Details
Acazicolcept ALPN-101 Phase 2 Clinical Alpine Immune Sciences, Abbvie Inc Graft vs Host Disease; Autoimmune Diseases; Lupus Erythematosus, Systemic; Lymphoproliferative Disorders; Inflammation Details
Alomfilimab KY-1044 Phase 2 Clinical Kymab Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Esophageal Neoplasms; Stomach Neoplasms; Triple Negative Breast Neoplasms; Neoplasms; Pancreatic Neoplasms; Melanoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Neoplasm Metastasis Details
Vopratelimab JTX-2011 Phase 2 Clinical Jounce Therapeutics Neoplasms; Carcinoma, Non-Small-Cell Lung Details

This web search service is supported by Google Inc.

totop