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CD19

요약

Name:B-lymphocyte antigen CD19
Target Synonym:Differentiation antigen CD19,CD19 Molecule,B-Lymphocyte Surface Antigen B4,CD19 Antigen,B-Lymphocyte Antigen CD19,CVID3,B4,Antigens, CD19,CD19,T-cell surface antigen Leu-12
Number of Launched Drugs:12
Number of Drugs in Clinical Trials:310
Lastest Research Phase:NDA/BLA

Antibody Licensing

Project Name Project Stage Molecule Type Host Species Therapeutic Area Indications
CD19 mAb - 01 PCC AutoImmunity,Hematological Malignancy Blood tumor,Autoimmune disease

라이센싱

Project Name Modality Therapeutic Area Indications Stage Right Available
PEGylation CD3 + CD19 bsAb Monospecific antibody Immunological disease Immunodeficiencies IND Global

제품 리스트 구매

제품번호 제품 설명 구조 순도 특징
CD9-H53H4 Human Human CD19 (20-291) Protein, His Tag
CD9-H53H4-structure
CD9-H53H4-sds
SCRAJ-STT216 Human Raji/Human CD19 Knockout Stable Cell Line Development Service
CD9-FM7A1 Mouse FITC-Labeled Monoclonal Anti-Human CD19 Antibody, Mouse IgG2a (FMC63) (0.03% Proclin)
CD9-M5257 Mouse Mouse CD19 Protein, Fc Tag (MALS verified)
CD9-M5257-structure
CD9-M5257-sds
CD9-C5354 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque CD19 (20-292) Protein, Fc Tag (MALS & SPR verified)
CD9-C5354-structure
CD9-C5354-sds
FABm004-02 Mouse APC-Labeled Monoclonal Anti-Human CD19 Antibody, Mouse IgG2a (FMC63)
FM3-PCFM7 Mouse PE-Labeled Monoclonal Anti-Human CD19 Antibody, Mouse IgG2a (FMC63)
CHEK-ATP003 Human HEK293/Human CD19 Stable Cell Line
MBS-C002 Human ActiveMax® Human CD19 μBeads, premium grade (for cells)
HGS-S259 Rabbit Recombinant Monoclonal Anti-CD19 Antibody, Rabbit (4A6)
CD9-HA2H3 Human Alexa Fluor™ 488-Labeled Human CD19 (20-291) Protein, His TagStar Staining
CD9-HA2H3-structure
CD9-HA2H6 Human Alexa Fluor™ 647-Labeled Human CD19 (20-291) Protein, His TagStar Staining
CD9-HA2H6-structure
CD9-H82F6 Human Biotinylated Human CD19 (20-291) Protein, Fc,Avitag™, premium grade
CD9-H82F6-structure
CD9-H82F6-sds
CD9-M52H8 Mouse Mouse CD19 Protein, His Tag
CD9-M52H8-structure
CD9-M52H8-sds
CD9-HA2H7 Human Alexa Fluor™ 555-Labeled Human CD19 (20-291) Protein, His TagStar Staining
CD9-HA2H7-structure
CD9-HA2H5 Human APC-Labeled Human CD19 (20-291) Protein, His Tag (Site-specific conjugation)
CD9-HA2H5-structure
CHEK-ATS056 Human HEK293/Human Anti-CD19 Stable Cell Line
CD9-HA2H9 Human APC-Labeled Human CD19 (20-291) Protein, His TagStar Staining
CD9-HA2H9-structure
CD9-HP2H5 Human PE-Labeled Human CD19 (20-291) Protein, His TagStar Staining
CD9-HP2H5-structure
CD9-R52H6 Rat Rat CD19 Protein, His Tag
CD9-R52H6-structure
CD9-R52H6-sds
CD9-C52H4 Canine Canine CD19 Protein, His Tag
CD9-C52H4-structure
CD9-C52H4-sds
CD9-R52H3 Rabbit Rabbit CD19 Protein, His Tag
CD9-R52H3-structure
CD9-R52H3-sds
CD9-HF2H3 Human FITC-Labeled Human CD19 (20-291) Protein, His TagStar Staining
CD9-HF2H3-structure
CD9-HF2H3-sds
CD9-C5221 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque CD19 (20-292) Protein, His Tag
CD9-C5221-structure
CD9-C5221-sds
MBS-K005 Human Human CD19-coupled Magnetic Beads
CD9-H82E9 Human Biotinylated Human CD19 (20-291) Protein, His,Avitag™, premium grade
CD9-H82E9-structure
CD9-H82E9-sds
CD9-HP2H3 Human PE-Labeled Human CD19 (20-291) Protein, His Tag (Site-specific conjugation)
CD9-HP2H3-structure
CD9-H5258 Human Human CD19 (20-291) Protein, Mouse IgG2a Fc Tag (MALS verified)
CD9-H5258-structure
CD9-H5258-sds
CD9-HF251 Human FITC-Labeled Human CD19 (20-291) Protein, Fc Tag
CD9-HF251-structure
CD9-HF251-sds
CD9-HF2H2 Human FITC-Labeled Human CD19 (20-291) Protein, His Tag
CD9-HF2H2-structure
CD9-HF2H2-sds
CD9-H5251 Human Human CD19 (20-291) Protein, Fc Tag, premium grade
CD9-H5251-structure
CD9-H5251-sds
CD9-H52H2 Human Human CD19 (20-291) Protein, His Tag (SPR verified)
CD9-H52H2-structure
CD9-H52H2-sds
CD9-C5251 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque CD19 (20-292) Protein, Fc Tag
CD9-C5251-structure
CD9-C5251-sds
CD9-H8259 Human Biotinylated Human CD19 Protein, Fc Tag, ultra sensitivity (primary amine labeling)
CD9-H8259-structure
CD9-H8259-sds
CD9-H5259 Human Human CD19 (20-291) Protein, Fc Tag, low endotoxin
CD9-H5259-structure
CD9-H5259-sds

일부의 생물활성 데이터

SCRAJ-STT216-Cell-based assay
 CD19 FACS

Expression analysis of human CD19 on Raji/Human CD19 Knockout Stable Cell Line by FACS.
Cell surface staining was performed on Raji/Human CD19 Knockout Stable Cell Line using PE-labeled anti-human CD19 antibody. The Raji cells were stained with PE-labeled anti-human CD19 antibody as the positive control cell. The Raji cells were stained with PE-labeled isotype control antibody as the negative control cell.

CD9-FM7A1-Cell-based assay
 CD19 FACS

Flow cytometric analysis of Human peripheral blood lymphocytes staining with FITC-Labeled Monoclonal Anti-Human CD19 Antibody, Mouse IgG2a (FMC63) (Cat. No. CD9-FM7A1) at 1:50 dilution (2 μL of the antibody stock solution corresponds to labeling of 1e6 cells in a final volume of 100 µL), compared with isotype control antibody. FITC signal was used to evaluate the binding activity (QC tested).

CD9-M5257-SPR
 CD19 SPR

Rat/IgG2a,Kappa Anti-CD19 Antibody immobilized on CM5 Chip can bind Mouse CD19 Protein, Fc Tag (Cat. No. CD9-M5257) with an affinity constant of 94.2 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

CD9-C5354-SPR
 CD19 SPR

Cynomolgus / Rhesus macaque CD19 (20-292) Protein, Fc Tag (Cat. No. CD9-C5354) immobilized on CM5 Chip can bind Anti-CD19 Antibody with an affinity constant of 2.70 nM as determined in a SPR assay (Biacore 8K) (QC tested).

사용자 리뷰

Synonym Name

CD19,B4,CVID3,MGC12802

Background

B-lymphocyte antigen CD19 is also known as CD19 (Cluster of Differentiation 19), is a single-pass type I  membrane protein which contains two Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. It primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI-3 kinase. As on T cells, several surface molecules form the antigen receptor and form a complex on B lymphocytes. The (almost) B cell-specific CD19 phosphoglycoprotein is one of these molecules. The others are CD21 and CD81. These surface immunoglobulin (sIg)-associated molecules facilitate signal transduction. On living B cells, anti-immunoglobulin antibody mimicking exogenous antigen causes CD19 to bind to sIg and internalize with it. The reverse process has not been demonstrated, suggesting that formation of this receptor complex is antigen-induced. This molecular association has been confirmed by chemical studies. Mutations in CD19 are associated with severe immunodeficiency syndromes characterized by diminished antibody production. CD19 has been shown to interact with: CD81, CD82, Complement receptor 2, and VAV2.

Clinical and Translational Updates

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