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Your Position: 홈 > CD117

CD117

요약

Name:Stem cell growth factor receptor
Target Synonym:EC 2.7.10,EC:2.7.10.1,MASTC,KIT Proto-Oncogene Receptor Tyrosine Kinase,V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene-Like Protein,p145 c-kit,SCFR,KIT,Proto-Oncogene C-Kit,Proto-Oncogene Tyrosine-Protein Kinase Kit,Soluble KIT Variant 1,C-Kit Protooncogene,CD117 Antigen,Piebald Trait,EC 2.7.10.1,C-Kit,CD117,Proto-Oncogene Proteins c-kit,Mast/stem cell growth factor receptor Kit,PBT,Piebald trait protein,Tyrosine-protein kinase Kit,KIT Proto-Oncogene, Receptor Tyrosine Kinase,v-kit Hardy-
Number of Launched Drugs:16
Number of Drugs in Clinical Trials:32
Lastest Research Phase:Approved

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제품번호 종 제품 설명 구조 순도 특징
CD7-C82E4 Cynomolgus Biotinylated Cynomolgus CD117 / c-kit Protein, His,Avitag (MALS verified)
CD7-C82E4-structure
CD7-C82E4-sds
CD7-C52H9 Cynomolgus Cynomolgus CD117 / c-kit Protein, His Tag (MALS verified)
CD7-C52H9-structure
CD7-C52H9-sds
CD7-H82E6 Human Biotinylated Human CD117 / c-kit Protein, His,Avitag (MALS verified)
CD7-H82E6-structure
CD7-H82E6-sds
CD7-R5259 Rhesus macaque Rhesus macaque CD117 / c-kit Protein, Fc Tag (MALS verified)
CD7-R5259-structure
CD7-R5259-sds
CD7-M5259 Mouse Mouse CD117 / c-kit Protein, Fc Tag (MALS verified)
CD7-M5259-structure
CD7-M5259-sds
CD7-H5255 Human Human CD117 / c-kit Protein, Fc Tag (MALS verified)
CD7-H5255-structure
CD7-H5255-sds
CD7-H52H4 Human Human CD117 / c-kit Protein, His Tag (MALS verified)
CD7-H52H4-structure
CD7-H52H4-sds

일부의 생물활성 데이터

CD7-H52H4-SPR
CD117 SPR

Biotinylated Human SCF, Avitag,His Tag (Cat. No. SCF-H82E1) captured on Biotin CAP-Series S Sensor Chip can bind Human CD117, His Tag (Cat. No. CD7-H52H4) with an affinity constant of 0.236 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
CD7-C52H9-ELISA
CD117 ELISA

Immobilized Cynomolgus CD117, His Tag (Cat. No. CD7-C52H9) at 2 μg/mL (100 μL/well) can bind Biotinylated Human SCF, Avitag,His Tag (Cat. No. SCF-H82E1) with a linear range of 0.2-5 ng/mL (QC tested).

Protocol

사용자 리뷰

Synonym Name

CD117,SCFR,c-Kit,KIT

Background

Mast/stem cell growth factor receptor Kit (c-Kit), a member of  the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily, is also known as piebald trait protein (PBT), p145 c-kit, tyrosine-protein kinase Kit and CD117,which contains five Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. CD117 acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, CD117 can activate several signaling pathways. Furthermore, Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B.

Clinical and Translational Updates

Related Molecule

SCF

공개 약품 정보

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Anlotinib Dihydrochloride AL-3818 Approved Advenchen Laboratories Llc, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd 福可维 Mainland China Carcinoma, Non-Small-Cell Lung Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd 2018-05-08 Thyroid Neoplasms; Peritoneal Neoplasms; Colorectal Neoplasms; Urologic Neoplasms; Gastrointestinal Stromal Tumors; Hepatic Insufficiency; Bone Neoplasms; Endometrial Neoplasms; Gallbladder Neoplasms; Fallopian Tube Neoplasms; Medullary thyroid cancer (MTC); Sarcoma, Alveolar Soft Part; Esophageal Squamous Cell Carcinoma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Carcinoma, Hepatocellular; Melanoma; Osteoma; Gastroenteropancreatic neuroendocrine tumor; Small Cell Lung Carcinoma; Solid tumours; Ovarian Neoplasms; Head and Neck Neoplasms; Leiomyosarcoma; Esophageal Neoplasms; Stomach Neoplasms; Thoracic Neoplasms; Carcinoma, Renal Cell; Carcinoma, Ovarian Epithelial; Biliary Tract Neoplasms; Lymphoma, Large B-Cell, Diffuse; Neoplasms; Neuroendocrine Tumors; Sarcoma, Synovial; Liver Diseases; Sarcoma; Bile Duct Diseases; Nasopharyngeal Carcinoma Details
Imatinib mesylate CGP-57148B; CGP-57148; STI-571; QTI-571; CTI-571; VR325; AER-901; YD-312; TNX-201 Approved Novartis Pharma Ag glivic, 格列卫, Gleevec, Ruvise, Glivec, Gleevec/Glivec EU Leukemia, Myelogenous, Chronic Novartis Europharm Ltd 2001-05-10 Diabetes Mellitus, Type 1; Hypereosinophilic Syndrome; Leukemia; Head and Neck Neoplasms; Leukemia, Myelogenous, Chronic; Ovarian Neoplasms; Solid tumours; Hypertension, Pulmonary; Hematopoietic stem cell transplantation (HSCT); Neoplasm, Residual; Skin Melanoma; Hematologic Neoplasms; Genital Diseases, Male; Ovarian germ cell tumor; Fibrosarcoma; Lymphoma, B-Cell, Marginal Zone; Leukemia, Myeloid, Accelerated Phase; Loiasis; Rhinitis, Allergic, Seasonal; Polycythemia Vera; Genital Neoplasms, Male; Abdominal Neoplasms; Leukemia, Hairy Cell; Histiocytoma, Malignant Fibrous; Desmoplastic Small Round Cell Tumor; Rectal Neoplasms; Stomach Neoplasms; Myeloproliferative Disorders; Skin Neoplasms; Leukemia, Myelomonocytic, Chronic; Coronavirus Disease 2019 (COVID-19); Scleroderma, Systemic; Graft vs Host Disease; Dermatofibrosarcoma; Liver Cirrhosis; Neoplasms; Neurofibromatoses; Mastocytosis, Systemic; Idiopathic Pulmonary Fibrosis; Myelodysplastic Syndromes; Carcinoma, Ovarian Epithelial; Small Cell Lung Carcinoma Details
Lenvatinib Mesylate MK-7902; ER-203492-00; E-7080 Approved Eisai Co Ltd Kisplyx, Lenvima, Lenvima/Kisplyx, 乐卫玛 United States Thyroid Neoplasms Eisai Inc 2015-02-13 Neuroendocrine Tumors; Paraganglioma; Thyroid Cancer, Papillary; Melanoma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Glioma; Lymphoma; Endometrial Neoplasms; Thyroid Neoplasms; Hepatic Insufficiency; Breast Neoplasms; Cholangiocarcinoma; Osteosarcoma; Solid tumours; Carcinoma, Adenoid Cystic; Adenocarcinoma, Follicular; Liver Diseases; Thyroid Carcinoma, Anaplastic; Adenocarcinoma of Lung; Neoplasms; Renal Insufficiency; Pheochromocytoma; Esophageal Neoplasms; Carcinoma, Renal Cell; Ovarian Neoplasms; Liver Neoplasms; Biliary Tract Neoplasms Details
Regorafenib DAST; BAY-73-4506 Approved Bayer AG Stivarga, Resihance United States Colorectal Neoplasms Bayer Healthcare Pharmaceuticals Inc 2012-09-27 Leukemia, Myeloid, Acute; Sarcoma, Ewing; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Bone Neoplasms; Peritoneal Neoplasms; Bile Duct Neoplasms; Esophageal adenocarcinoma; Lung Neoplasms; Thyroid Neoplasms; Fallopian Tube Neoplasms; Osteosarcoma; Thymoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Neoplasm Metastasis; Adenocarcinoma; Somatostatinoma; Gastrointestinal Neoplasms; Melanoma; Meningioma; Neoplasms; Solid tumours; Liver Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Insulinoma; Carcinoma, Islet Cell; Hemangiosarcoma; Rectal Neoplasms; Carcinoma, Renal Cell; Ovarian Neoplasms; Colonic Neoplasms; Carcinoma, Ovarian Epithelial; Pancreatic Neoplasms; Carcinoma, Transitional Cell; Adenoma; Glucagonoma; Carcinoma, Adenoid Cystic; Gastrinoma; Sarcoma Details
Avapritinib BLU-285; CS-3007 Approved Blueprint Medicines Corp Ayvakit, Ayvakyt, 泰吉华, Taijihua United States Gastrointestinal Stromal Tumors Blueprint Medicines Corp 2020-01-09 Solid tumours; Hematologic Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Mastocytosis, Systemic; Central Nervous System Neoplasms; Leukemia, Mast-Cell; Sarcoma; Breast Neoplasms; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Lung Neoplasms; Melanoma; Adenocarcinoma Details
Vorolanib CM-082; X-82; EYP-1901 Approved Tyrogenex Inc 伏美纳, DURAVYU™ Mainland China Carcinoma, Renal Cell Betta Pharmaceuticals Co Ltd 2023-06-07 Diabetic macular oedema; Melanoma; Carcinoma, Non-Small-Cell Lung; Diabetic Retinopathy; Macular Degeneration; Carcinoma, Hepatocellular; Choroidal Neovascularization; Adenocarcinoma; Eye Diseases; Leukemia, Myeloid, Acute; Retinal Degeneration; Solid tumours; Wet Macular Degeneration; Retinal Diseases; Neoplasms; Small Cell Lung Carcinoma; Pancreatic Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Carcinoma, Renal Cell; Kidney Neoplasms Details
Ripretinib DCC-2618 Approved Deciphera Pharmaceuticals Qinlock, 擎乐 United States Gastrointestinal Stromal Tumors Deciphera Pharmaceuticals Llc 2020-05-15 Mastocytosis, Systemic; Neoplasms; Gastrointestinal Stromal Tumors Details
Olverembatinib D-824; GZD-824; APG-1351; GIBH-824; HQP-1351 Approved Guangzhou Institute Of Biomedicine And Health, Chinese Academy Of Sciences 耐立克 Mainland China Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Accelerated Phase Guangzhou Shunjian Biomedical Technology Co Ltd 2021-11-25 Leukemia; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Accelerated Phase; Solid tumours; Leukemia, Myeloid; Leukemia, Lymphoid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Gastrointestinal Stromal Tumors Details
Ponatinib Hydrochloride AP24534 hydrochloride; AP24534-HCL; AP24534 HCl; INCB-84344; AP-24534 Approved Ariad Iclusig United States Leukemia, Myelogenous, Chronic; Precursor Cell Lymphoblastic Leukemia-Lymphoma Ariad Pharmaceuticals Inc 2012-12-14 Precursor Cell Lymphoblastic Leukemia-Lymphoma; Carcinoma, Non-Small-Cell Lung; Leukemia, Biphenotypic, Acute; Thyroid Neoplasms; Lymphoma; Leukemia, Myeloid, Acute; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Chronic-Phase; Philadelphia Chromosome; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Medullary thyroid cancer (MTC); Common Bile Duct Neoplasms; Leukemia, Myeloid, Accelerated Phase; Blast Crisis; Leukemia, Myelomonocytic, Chronic; Glioblastoma; Small Cell Lung Carcinoma; Adenocarcinoma of Lung; Hematologic Neoplasms; Head and Neck Neoplasms; Leukemia, Myelogenous, Chronic; Solid tumours; Leukemia Details
Sunitinib Malate PNU-290940AD; PHA-290940AD; SCAI-003; SU-010398; SU-11248; GB-102; PHA-290940; PNU-290940; SU-011248-L-malate salt Approved Pfizer Inc Sutent, 索坦 United States Carcinoma, Renal Cell; Gastrointestinal Stromal Tumors Cppi Cv 2006-01-26 Kidney Neoplasms; Skin Melanoma; Teratoma; Liver Neoplasms; Ovarian Neoplasms; Ependymoma; Head and Neck Neoplasms; Lymphoma, T-Cell, Peripheral; Solid tumours; Leukemia, Myeloid, Accelerated Phase; Leukemia, Myelogenous, Chronic; Leiomyosarcoma; Lymphoma, B-Cell; HIV Infections; Fibrosarcoma; Intestinal Neoplasms; Fibromatosis, Aggressive; Leukemia; Lymphoma, B-Cell, Marginal Zone; Carcinoma, Renal Cell; Pheochromocytoma; Stomach Neoplasms; Abdominal Neoplasms; Pelvic Neoplasms; Polycythemia Vera; Thoracic Neoplasms; Esophageal Neoplasms; Carcinoma, Islet Cell; Carcinoma; Histiocytoma, Malignant Fibrous; Hemangioblastoma; Squamous Cell Carcinoma of Head and Neck; Leukemia, Hairy Cell; Nose Neoplasms; Hypopharyngeal Neoplasms; Carcinoma, Ovarian Epithelial; Pancreatic neuroendocrine tumors (pNET); Plasmacytoma; Neoplasms; Pancreatic Neoplasms; Glioblastoma; Lymphoma, Large B-Cell, Diffuse; Lymphomatoid Granulomatosis; Lymphoma, Large-Cell, Immunoblastic; Myelodysplastic Syndromes; Carcinoma, Transitional Cell Details
Dasatinib Hydrate BMS-354825; XS-004; NSC-732517 Approved Bristol-Myers Squibb Company Spraysel, 施达赛, Dasynoc, Spricel, Sprycel United States Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myelogenous, Chronic Bristol-Myers Squibb Company 2006-06-28 Leukemia, Myeloid, Accelerated Phase; Leukemia, Myelogenous, Chronic; Leukemia; Liver Neoplasms; Hematologic Neoplasms; Hypereosinophilic Syndrome; Solid tumours; Lymphoma, B-Cell, Marginal Zone; Lymphoma, B-Cell; Bone metastases; Skin Melanoma; Rhabdomyosarcoma; Chondrosarcoma; Immunoproliferative Small Intestinal Disease; Ovarian Neoplasms; Leukemia, Myeloid; Cystadenocarcinoma; HIV Infections; Rectal Neoplasms; Polycythemia Vera; Leukemia, Lymphoid; Leukemia, Hairy Cell; Hormone-Resistant Prostate Neoplasms; Idiopathic Pulmonary Fibrosis; Colonic Neoplasms; Neoplasms; Salivary Gland Neoplasms; Skin Neoplasms; Myelodysplastic Syndromes; Scleroderma, Systemic; Glioblastoma; Lymphoma, Large B-Cell, Diffuse; Lymphomatoid Granulomatosis; Small Cell Lung Carcinoma; Leukemia, Myelomonocytic, Chronic; Mastocytosis, Systemic; Leukemia-Lymphoma, Adult T-Cell; Hodgkin Disease; Carcinoma, Verrucous; Lymphoma, Large-Cell, Immunoblastic; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Coronavirus Disease 2019 (C Details
Pexidartinib PLX-3397 Approved Daiichi Sankyo Co Ltd Turalio United States Giant Cell Tumor of Tendon Sheath Daiichi Sankyo Inc 2019-08-02 Prostatic Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Melanoma; Metastatic breast cancer; Leukemia, Myeloid, Acute; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Neurofibroma, Plexiform; Neurofibrosarcoma; Giant Cell Tumors; Sarcoma; Giant Cell Tumor of Tendon Sheath; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pancreatic Neoplasms; Neoplasms; Arthritis, Rheumatoid; Hodgkin Disease; Glioblastoma; Squamous Cell Carcinoma of Head and Neck; Synovitis, Pigmented Villonodular; Leukemia, Promyelocytic, Acute; Ovarian Neoplasms; Solid tumours Details
Pazopanib Hydrochloride GSK-786034; GW-786034B; SB-786034; GW-786034 Approved Glaxosmithkline Plc, Novartis Pharma Ag 维全特, Armala, Votrient, Patorma United States Carcinoma, Renal Cell; Sarcoma Novartis Pharma Ag 2009-10-19 Osteosarcoma; Germinoma; Fallopian Tube Neoplasms; Leukemia, Myeloid, Acute; Colorectal Neoplasms; Uterine Cervical Diseases; Genital Neoplasms, Female; Gliosarcoma; Gastrointestinal Stromal Tumors; Peritoneal Neoplasms; Chondrosarcoma, Extraskeletal Myxoid; Lung Neoplasms; Nasopharyngeal Carcinoma; Medullary thyroid cancer (MTC); Brain Neoplasms; Urethral Neoplasms; Psoriasis; Gastrinoma; Neuroblastoma; Prostatic Neoplasms; Breast Neoplasms; Neoplasms, Germ Cell and Embryonal; von Hippel-Lindau Disease; Thyroid Cancer, Papillary; Neoplasm Metastasis; Breast Neoplasms, Male; Uterine Cervical Neoplasms; Endodermal Sinus Tumor; Paraganglioma; Melanoma; Macular Degeneration; Carcinoma, Hepatocellular; Sarcoma; Gastrointestinal Neoplasms; Carcinoma, Non-Small-Cell Lung; Thyroid Neoplasms; Choriocarcinoma; Uterine Neoplasms; Lymphoma; Carcinoma, Neuroendocrine; Glioma; Carcinoma, Embryonal; Skin Melanoma; Neoplasms; Herpes Genitalis; Hemangiosarcoma; Squamous Cell Carcinoma of Head and Neck; Insulinoma; Pheochromo Details
Cabozantinib S-malate XL-184; BMS-907351; RO7047650; RO-7047650 Approved Exelixis Inc Cometriq, Cabometyx United States Thyroid Neoplasms; Carcinoma, Neuroendocrine Exelixis Inc 2012-11-29 Neuroblastoma; Thyroid Neoplasms; Hepatic Insufficiency; Astrocytoma; Peritoneal Neoplasms; Bile Duct Neoplasms; Colorectal Neoplasms; Gliosarcoma; Urethral Neoplasms; Sarcoma, Clear Cell; Uterine Neoplasms; Cholangiocarcinoma; Neurofibroma, Plexiform; Brain Neoplasms; Adenocarcinoma, Clear Cell; Carcinoma, Adenosquamous; Medullary thyroid cancer (MTC); Sarcoma, Ewing; Sarcoma; Osteosarcoma; Sarcoma, Alveolar Soft Part; Meningioma; Melanoma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Endometrioid; Thyroid Cancer, Papillary; Paraganglioma; Neoplasms, Germ Cell and Embryonal; Carcinoma, Hepatocellular; Prostatic Neoplasms; Glioma; Brain metastases; Endometrial Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Squamous Cell; Lymphoma; Carcinoma, Neuroendocrine; Fallopian Tube Neoplasms; Carcinoma, Renal Cell; Adenoma, Islet Cell; Glioblastoma; Carcinoma, Ovarian Epithelial; Renal Insufficiency; Hepatoblastoma; Pheochromocytoma; Carcinoid Tumor; Carcinoma, Merkel Cell; Rejection of liver transp Details
Sorafenib Tosylate NSC-724772; BAY-43-0006; BAY-43-9006; BAY-54-9085 Approved Onyx Pharmaceuticals Inc Nexavar, 多吉美 United States Carcinoma, Renal Cell Bayer Healthcare Pharmaceuticals Inc 2005-12-01 Liver Neoplasms; Leukemia, Myelogenous, Chronic; Leiomyosarcoma; Rhabdomyosarcoma; Solid tumours; Ovarian Neoplasms; Fibromatosis, Aggressive; Kidney Neoplasms; Leukemia, Myeloid; Head and Neck Neoplasms; Skin Melanoma; Lymphoma, B-Cell, Marginal Zone; Lymphoma, T-Cell, Peripheral; Leukemia, Erythroblastic, Acute; Squamous Cell Carcinoma of Head and Neck; Carcinoma; Histiocytoma, Malignant Fibrous; Carcinoma, Renal Cell; Stomach Neoplasms; Rectal Neoplasms; Carcinoma, Islet Cell; Insulinoma; Vipoma; Hemangiosarcoma; Esophageal Neoplasms; Wilms Tumor; Hypertension, Portal; Thyroid Carcinoma, Anaplastic; Neoplasms; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Pancreatic Neoplasms; Carcinoma, Ovarian Epithelial; Leukemia, Myelomonocytic, Acute; Lymphomatoid Granulomatosis; Carcinoma, Transitional Cell; Colonic Neoplasms; Salivary Gland Neoplasms; Lymphoma, Large B-Cell, Diffuse; Multiple Endocrine Neoplasia Type 2a; Lymphoma, Large-Cell, Immunoblastic; Leukemia-Lymphoma, Adult T-Cell; Carcinoma, Details
Midostaurin PKC-412; PKC-412A; CGP-41231; CGP-41251 Approved Novartis Pharma Ag Rydapt United States Hematologic Neoplasms; Leukemia, Myeloid, Acute; Mastocytosis, Systemic; Leukemia, Mast-Cell Novartis Pharmaceuticals Corp 2017-04-28 Leukemia; Hematologic Neoplasms; Mastocytosis, Systemic; Myelodysplastic Syndromes; Leukemia, Mast-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Mastocytosis Details

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
Barzolvolimab CDX-0159 Phase 3 Clinical Yale University, University Of Toronto - St. George Campus Chronic Urticaria; Prurigo Nodularis; Skin Diseases; Eosinophilic Esophagitis; Urticaria; Dermatitis, Atopic Details
Seralutinib GB-002; PK-10571 Phase 3 Clinical Gilead Sciences Inc Pulmonary Arterial Hypertension Details
Chiauranib CS-2164; CS2164 Phase 3 Clinical Shenzhen Chipscreen Biosciences Co Ltd Ovarian Neoplasms; Solid tumours; Small Cell Lung Carcinoma; Triple Negative Breast Neoplasms; Neoplasms; Sarcoma; Lymphoma, Non-Hodgkin; Carcinoma, Pancreatic Ductal; Carcinoma, Hepatocellular Details
Bezuclastinib PLX-9486; CGT-9486 Phase 3 Clinical Daiichi Sankyo Co Ltd Hematologic Neoplasms; Mastocytosis, Systemic; Leukemia, Mast-Cell; Gastrointestinal Stromal Tumors; Neoplasm Metastasis; Mastocytosis Details
oral enteric coated imatinib (Tenax Therapeutics) TNX-201 (Tenax Therapeutics) Phase 3 Clinical PH Precision Med Pulmonary Arterial Hypertension Details
Sitravatinib MGCD-516; IND-155305; MGCD-0516; MG-91516; MG-516 Phase 3 Clinical Mirati Therapeutics Inc Breast Neoplasms; Gastrointestinal Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Carcinoma, Hepatocellular; Endometrial Neoplasms; Lung Neoplasms; Metastatic breast cancer; Esophageal Squamous Cell Carcinoma; Mouth Neoplasms; Carcinoma, Squamous Cell; Hepatic Insufficiency; Ureteral Neoplasms; Solid tumours; Lung Diseases; Liposarcoma; Uveal melanoma; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Neoplasms; Carcinoma; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Kidney Neoplasms; Biliary Tract Neoplasms Details
Elenestinib BLU-263 Phase 3 Clinical Blueprint Medicines Corp Mastocytosis, Systemic; Mastocytosis Details
Autologous Human C-Kit Cardiac Stem Cells (CSCs) II (ISCI / University of Miami Miller School of Medicine) Phase 2 Clinical University Of Miami, Elpiscience (Shanghai) Biopharma Ltd Myocardial Infarction; Ventricular Dysfunction, Left Details
Telatinib EOC-315; BAY-57-9352 Phase 2 Clinical Bayer AG Solid tumours; Stomach Neoplasms Details
Briquilimab AMG-191; JSP-191; JSP191 Phase 2 Clinical Amgen Inc, National Heart, Lung And Blood Institute, Stanford University Chronic Urticaria; Myelodysplastic Syndromes; Severe Combined Immunodeficiency; Asthma; Leukemia, Myeloid, Acute; Granulomatous Disease, Chronic; Immunologic Deficiency Syndromes; Anemia, Sickle Cell Details
DCC-3009 DCC-3009 Phase 2 Clinical Deciphera Pharmaceuticals Inc Gastrointestinal Stromal Tumors Details
Sorafenib Tosylate/Comekibart MG-D-1609 Phase 2 Clinical Metagone Biotech Inc Solid tumours Details
Opelkibart elmanitin MGTA-117 Phase 2 Clinical Heidelberg Pharma AG Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
18F-Dasatinib 18F-SKI-249380; [18F]-Fluoro-BMS-354825; [18F]Dasatinib; [18F]SKI-249380; [18F]Fluoro-BMS-354825 Phase 1 Clinical Memorial Sloan Kettering Cancer Center Bone Marrow Neoplasms; Carcinoma; Neoplasms; Sarcoma; Lymphoma; Diagnostic agents; Melanoma Details
Tafetinib Malate SIM-0702; SIM-1005; SIM-010603 Phase 1 Clinical Jiangsu Simcere Pharmaceutical Co Ltd, Nanjing Yoko Biomedical Co Ltd, Jilin Boda Pharmaceutical Co Ltd Neoplasms Details
Amorphous Formulation of Sorafenib in Mesoporous Magnesium Carbonate DPH001; DPH-001 Phase 1 Clinical Disruptive Pharma AB Details
QBH-196 QBH-196 Phase 1 Clinical Shenyang Pharmaceutical University Solid tumours; Stomach Neoplasms Details
ETN-101 ETN101; ETN-101; MBP-11901 Phase 1 Clinical Etnova Therapeutics Corp Liver Neoplasms; Carcinoma, Hepatocellular Details
THB-335 THB-335; THB335 Phase 1 Clinical Third Harmonic Bio Inflammation Details
CDX-622 CDX-622 Phase 1 Clinical Celldex Therapeutics Inc Fibrosis; Inflammation; Hypersensitivity Details
QX-013N QX-013-N; QX013N Phase 1 Clinical Qyuns Therapeutics Co Ltd Chronic Urticaria; Urticaria Details
NN-2101 NN-2101 Phase 1 Clinical Novelty Nobility Inc Retinal Diseases; Diabetic macular oedema; Wet Macular Degeneration; Diabetic Retinopathy; Retinal Vein Occlusion Details
NN-3201 NN-3201 Phase 1 Clinical Novelty Nobility Inc Carcinoma, Renal Cell; Small Cell Lung Carcinoma; Uveal melanoma; Neuroendocrine Tumors; Carcinoma, Adenoid Cystic; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Acute Details
THB-001 THB-001 Phase 1 Clinical Novartis Corp Gastrointestinal Diseases; Chronic Urticaria; Respiratory Tract Diseases Details
T-1301 T-1301; DBPR-216 Phase 1 Clinical Taivex Therapeutics Corp Solid tumours; Lymphoma Details
GS-0174 GS-0174 Phase 1 Clinical Forty Seven Inc Hematologic Neoplasms Details
TR-64 TR-64 Phase 1 Clinical Tarapeutics Science Inc Solid tumours; Gastrointestinal Stromal Tumors Details
AZD-3229 NB-003; NB003; AZD-3229; AZD3229 Phase 1 Clinical Astrazeneca Turkey Solid tumours; Gastrointestinal Stromal Tumors; Influenza B virus infection Details
AGX-0073 AGX-0073 Phase 1 Clinical Shanghai Aojian Biological Technology Co Ltd Solid tumours Details
Sorafenib tosylate (Bio-Synectics) BS-104 Clinical Bio-Synectics Inc Details

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