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IL-13

요약

Name:Interleukin-13
Target Synonym:Interleukin-13,IL13,Interleukin 13,IL-13,Bronchial Hyperresponsiveness-1 (Bronchial Asthma),Allergic Rhinitis,P600,NC30,MGC116789,MGC116788,BHR1,MGC116786,ALRH
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Approved

제품 리스트 비교 또는 구매

일부의 생물활성 데이터

IL3-H52H4-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Human IL-13, His Tag (Cat. No. IL3-H52H4) stimulates proliferation of TF-1 cells. The EC50 for this effect is 0.05-0.08 μg/mL (Routinely tested).

IL3-H52H4-SPR
Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Human IL-13 R alpha 1 Protein, His,Avitag (Cat. No. IL1-H82E8) captured on Biotin CAP-Series S Sensor Chip can bind Human IL-13, His Tag (Cat. No. IL3-H52H4) with an affinity constant of 34.4 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

IL3-H82E5-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Biotinylated Human IL-13, His,Avitag (Cat. No. IL3-H82E5) on SA Biosensor, can bind Human IL-13 R alpha 2, His Tag (Cat. No. IL2-H52H5) with an affinity constant of 6.31 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

IL13,ALRH,BHR1,MGC116786,MGC116788,MGC116789,P600,Interleukin-13

Background

Interleukin 13 (IL13) is also known as ALRH, BHR1and P600, is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses. IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. IL-13 induces matrix metalloproteinases (MMPs) as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.

Clinical and Translational Updates

Related Molecule

공개 약품 정보

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Tralokinumab BAK-502G9; CAT-354 Approved Medimmune Llc Adtralza, ADBRY United States Dermatitis, Atopic Leo Pharma A/S 2021-06-17 Idiopathic Pulmonary Fibrosis; Asthma; Colitis, Ulcerative; Dermatitis, Atopic Details

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
Dectrekumab/VAK-694 QBX-258 Phase 2 Clinical Novartis Pharma Ag Lymphedema; Asthma Details
SAR-443726 SAR-443726 Phase 1 Clinical Sanofi Dermatitis, Atopic Details
SAR-443765 SAR-443765 Phase 1 Clinical Sanofi Inflammation Details
AIR-645 AIR-645; ISIS-369645 Ionis Pharmaceuticals Inc Details
Romilkimab SUB-33159; SAR-156597 Sanofi Details
GSK-2434735 GSK-2434735 Glaxosmithkline Plc Details
Lebrikizumab RG-3637; TNX-650; Anti-IL-13; MILR-1444A; PRO-301444; RO-4909832; RO-5490255; DRM-06; R-3637 Phase 3 Clinical Genentech Inc Alzheimer Disease Details
Abrezekimab CDP-7766; VR-942; UCB-4144 Vectura, Ucb Details
Berdazimer sodium NVN1000-SB206; MAP3-NONOate - SB-206; SB-019; NVN-1000-SB-206-Novan; SB-206 Novan Details
AMG-317 AMG-317 Amgen Inc Details
RG-1671 R-1671; RG-1671 F. Hoffmann-La Roche Ltd Details
RO-7040547 RG-7990; BIT-7201A; RO-7040547 Genentech Inc, Novimmune Sa Details
Cendakimab ABT-308; RPC-4046; CC-93538 Phase 3 Clinical Abbott Laoratories Eosinophilic gastroenteritis (EG); Eosinophilic Esophagitis; Asthma; Dermatitis, Atopic; Eczema Details

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