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Your Position: 홈 > VEGF-D

VEGF-D

요약

Name:Vascular endothelial growth factor D
Target Synonym:C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D),FIGF,c-Fos-induced growth factor,VEGFD,VEGF-D,Vascular Endothelial Growth Factor D
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 3 Clinical

제품 리스트 구매

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제품번호 종 제품 설명 구조 순도 특징
VED-M5253 Mouse Mouse VEGF-D Protein, Fc Tag
VED-M5253-structure
VED-M5253-sds
VED-M82E4 Mouse Biotinylated Mouse VEGF-D Protein, His,Avitag™
VED-M82E4-structure
VED-M82E4-sds
VED-C82E3 Cynomolgus Biotinylated Cynomolgus VEGF-D Protein, His,Avitag™
VED-C82E3-structure
VED-C82E3-sds
VED-H52H3 Human Human VEGF-D Protein, His Tag (MALS verified)
VED-H52H3-structure
VED-H52H3-sds
VED-H5228 Human Human VEGF-D Protein, His Tag
VED-H5228-structure
VED-H5228-sds

일부의 생물활성 데이터

VED-M5253-SPR
VEGF-D SPR

Mouse VEGF-D Protein, Fc Tag (Cat. No. VED-M5253) captured on CM5 chip via anti-Human IgG Fc antibody, can bind Mouse VEGF R3 Protein, Mouse IgG2a Fc Tag (Cat. No. FL4-M5251) with an affinity constant of 6.69 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
VED-M82E4-SPR
VEGF-D SPR

Biotinylated Mouse VEGF-D Protein, His,Avitag (Cat. No. VED-M82E4) immobilized on CM5 Chip can bind Mouse VEGF R3 Protein, Mouse IgG2a Fc Tag (Cat. No. FL4-M5251) with an affinity constant of 10.6 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol

Synonym Name

FIGF,VEGFD

Background

Vascular endothelial growth factor D (VEGF-D) is also known as C-fos induced growth factor (FIGF), which belongs to the PDGF / VEGF growth factor family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. This secreted protein VEGF-D / FIGF undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-2 and VEGFR-3. The structure and function of this protein is similar to those of VEGFC. FIGF / VEGF-D is highly expressed in lung, heart, small intestine and fetal lung. FIGF / VEGF-D may function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR / FLK1) and VEGFR-3 (FLT4) receptors.

Clinical and Translational Updates

Related Molecule

VEGF R3

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
Sozinibercept OPT-302; VGX-300 Phase 3 Clinical Orphan Europe Sarl Neovascularization, Pathologic; Retinal Diseases; Diabetic macular oedema; Retinal Degeneration; Eye Diseases; Macular Degeneration Details
EG-016 EG-016; Ad-VEGF-A Phase 2 Clinical Ark Therapeutics Ltd Peripheral Vascular Diseases Details
EG-011 EG-011; Ad-VEGF-D Phase 2 Clinical Ark Therapeutics Ltd Angina Pectoris Details

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