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uPAR

요약

Name:Urokinase plasminogen activator surface receptor
Target Synonym:Monocyte activation antigen Mo3,U-PAR,uPAR,CD87,Urokinase-Type Plasminogen Activator (UPA) Receptor,URKR,U-Plasminogen Activator Receptor Form 2,CD87 Antigen,Plasminogen Activator, Urokinase Receptor,MO3
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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일부의 생물활성 데이터

UPR-HP2H7-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

5e5 of anti-uPAR CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human uPAR, His Tag (Cat. No. UPR-HP2H7) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).

UPR-M52H3-SPR
Human_FcRn_Heterodimer_Protein_SPR

Mouse uPAR, His Tag (Cat. No. UPR-M52H3) immobilized on CM5 Chip can bind Human PLAU, His Tag (Cat. No. PLU-H5229) with an affinity constant of 14.1 nM as determined in a SPR assay (Biacore 8K) (QC tested).

UPR-HF2H3-ELISA
FITC-Labeled Human uPAR, His TagFITC-Labeled Human uPAR, His Tag (Cat. No. UPR-HF2H3) ELISA bioactivity

Immobilized Anti-uPAR Antibody, Mouse IgG1 at 1 μg/mL (100 μL/well) can bind FITC-Labeled Human uPAR, His Tag (Cat. No. UPR-HF2H3) with a linear range of 39-156 ng/mL (QC tested).

Synonym Name

uPAR,PLAUR,CD87,MO3

Background

Urokinase plasminogen activator surface receptor (U-PAR) is also known as PLAUR, Monocyte activation antigen Mo3, CD antigen CD87. PLAUR contains three UPAR/Ly6 domains. U-PAR is expressed in neurons of the rolandic area of the brain (at protein level) and is also expressed in the brain. PLAUR / CD87 interacts with MRC2, SRPX2 and SORL1. PLAUR / UPAR acts as a receptor for urokinase plasminogen activator and plays a role in localizing and promoting plasmin formation. U-PAR mediates the proteolysis-independent signal transduction activation effects of U-PA.

Clinical and Translational Updates

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