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Your Position: 홈 > Osteoprotegerin

Osteoprotegerin

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TNB-H5220 Human Human Osteoprotegerin / TNFRSF11B Protein, His Tag
TNB-H5220-structure
TNB-H5220-sds
TNB-H5259 Human Human Osteoprotegerin / TNFRSF11B Protein, Fc Tag
TNB-H5259-structure
TNB-H5259-sds

일부의 생물활성 데이터

TNB-H5220-BLI
Osteoprotegerin BLI

Loaded Human Osteoprotegerin, His Tag (Cat. No. TNB-H5220) on HIS1K Biosensor, can bind Human TRAIL with an affinity constant of 0.831 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
TNB-H5259-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human TRAIL, His Tag on HIS1K Biosensor, can bind Human Osteoprotegerin, Fc Tag (Cat. No. TNB-H5259) with an affinity constant of 1.65 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

TNFRSF11B,OCIF,OPG,Osteoprotegerin

Background

Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG). TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11. TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

Clinical and Translational Updates

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