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Your Position: > TGF-Beta 2

TGF-Beta 2

요약

Name:Transforming growth factor beta 2
Target Synonym:TGF-beta-2,BSC-1 Cell Growth Inhibitor,Polyergin,Glioblastoma-Derived T-Cell Suppressor Factor,Cetermin,LDS4,TGFB2,Transforming Growth Factor, Beta 2,Transforming Growth Factor Beta-2 Proprotein,TGF-Beta2,Transforming Growth Factor Beta 2,G-TSF,Transforming Growth Factor beta2,LAP,Prepro-Transforming Growth Factor Beta-2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 3 Clinical

제품 리스트 비교 또는 구매

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제품번호 제품 설명 구조 순도 특징
TG2-H4215 Human Human TGF-Beta 2 / TGFB2 Protein, Tag Free
TG2-H4215-structure
TG2-H4215-sds

일부의 생물활성 데이터

TG2-H4215-MALS-HPLC
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human TGFBR2, Fc Tag (Cat. No. TG2-H5252) on Protein A Biosensor, can bind Human TGF-Beta 2, Tag Free (Cat. No. TG2-H4215) with an affinity constant of 8.09 nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

Synonym Name

TGFB2,MGC116892,TGFβ2,TGF-beta2

Background

Transforming growth factor beta 2 ( TGFB2) is also known as TGF-β2, G-TSF, TGFB. is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The TGFB2 protein helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (motility), and the self-destruction of cells (apoptosis). The TGFB2 protein can inhibit the T cell growth by IL-2-dependent. and can inhibit immune surveillance during tumor development, the protein promoting tumor growth with an autocrine manner. TGF-β2 can affect the viability of killer cells and reduce the expression of IL-2, IL-6, IL-10, IFN-γ and other cytokines.TGFB2 plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages.

Clinical and Translational Updates

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
LP-008 LP-008 Phase 1 Clinical Lepu Biotech Co Ltd Solid tumours Details
Mannose phosphate M6P Renovo Details
TU-2218 TU-2218 TiumBio Co Ltd Details
ENERGI-F701 ENERGI-F701 Energenesis Biomedical Details
Trabedersen OT-101; AP-2/09; AP-2/09-DS; AP-12009; OT-201 Isarna Therapeutics Details
Bintrafusp alfa M-7824; GSK-4045154; MSB-0011359C Phase 3 Clinical Merck Serono Solid tumours; Biliary Tract Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Neoplasms; Carcinoma, Transitional Cell; Urinary Bladder Neoplasms; Cholangiocarcinoma; Nasopharyngeal Carcinoma; Sarcoma; Gallbladder Neoplasms; Lung Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details

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