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Sonic Hedgehog

요약

Name:Sonic Hedgehog Homolog
Target Synonym:HHG-1,Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains,ShhNC,Shh N-terminal processed signaling domains,ShhNp,ShhN,Sonic hedgehog protein,Sonic hedgehog protein N-product,Sonic Hedgehog Signaling Molecule,Sonic Hedgehog (Drosophila) Homolog
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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제품번호 제품 설명 구조 순도 특징
SH7-H5229 Human Human Sonic Hedgehog / Shh Protein, His Tag
SH7-H5229-structure
SH7-H5229-sds

Synonym Name

SHH,HHG-1,Sonic hedgehog,HLP3,HPE3,SMMCI,TPT,TPTPS

Background

Sonic hedgehog protein (SHH) is also known as HHG-1, which belongs to the hedgehog family. SHH is expressed in fetal intestine, liver, lung, and kidney and not expressed in adult tissues. Sonic hedgehog protein can be cleavage into sonic hedgehog protein N-product and sonic hedgehog protein C-product by autolysis. SHH binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development. The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity.

Clinical and Translational Updates

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
IMP5471-CA Phase 1 Clinical Shanghai Impact Pharmaceutical Co Ltd Hematologic Diseases Details
ACC-006 ACC-006 Phase 2 Clinical Jiangsu Aidea Pharmaceutical Co Ltd, China Pharmaceutical University Solid tumours; Carcinoma, Non-Small-Cell Lung Details
Sulforadex SFX-01 Phase 2 Clinical Evgen Pharma, Lalilab, Pharmagra Labs Autistic Disorder; Precancerous Conditions; Subarachnoid Hemorrhage; Renal Insufficiency, Chronic; Parkinson Disease; Asthma; Hyperplasia; Carcinoma in Situ; Breast Neoplasms; Prostatic Neoplasms; Head and Neck Neoplasms; Heart Diseases; Neurodevelopmental Disorders; Neoplasms; Schizophrenia; Anaplasia; Squamous Cell Carcinoma of Head and Neck; Autism Spectrum Disorder; Heart Failure, Diastolic; Drug-Related Side Effects and Adverse Reactions Details

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