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RENIN

요약

Name:Renin
Target Synonym:REN,Renin,Angiotensinogenase,Angiotensin-Forming Enzyme,Renin Precursor, Renal,HNFJ2,EC:3.4.23.15,EC 3.4.23.15,EC 3.4.23
Number of Launched Drugs:4
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Approved

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제품번호 제품 설명 구조 순도 특징
REN-M5222 Mouse Mouse RENIN Protein, His Tag
REN-M5222-structure
REN-M5222-sds
REN-H5221 Human Human RENIN Protein, His Tag
REN-H5221-structure
REN-H5221-sds

Synonym Name

REN,FLJ10761,Renin,angiotensinogenase

Background

Renin is also known as REN and angiotensinogenase, is a circulating enzyme that participates in the body's renin-angiotensin system (RAS), and plays an essential role in the elevation of arterial blood pressure and increased sodium retention by the kidney. Renin activates the renin-angiotensin system by cleaving angiotensinogen, produced by the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE, the angiotensin-converting enzyme primarily within the capillaries of the lungs. Renin is secreted from kidney cells, which are activated via signaling from the macula densa, which responds to the rate of fluid flow through the distal tubule, by decreases in renal perfusion pressure (through stretch receptors in the vascular wall), and by sympathetic nervous stimulation, mainly through beta-1 receptor activation. Renin can bind to ATP6AP2, which results in a fourfold increase in the conversion of angiotensinogen to angiotensin I over that shown by soluble renin. In addition, renin binding results in phosphorylation of serine and tyrosine residues of ATP6AP2. The level of renin mRNA appears to be modulated by the binding of HADHB, HuR and CP1 to a regulatory region in the 3' UTR. An over-active renin-angiotension system leads to vasoconstriction and retention of sodium and water. These effects lead to hypertension. Therefore, renin inhibitors can be used for the treatment of hypertension.

Clinical and Translational Updates

공개 약품 정보

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Aliskiren Hemifumarate/Amlodipine Besilate/Hydrochlorothiazide Approved Novartis Pharma Ag Rasitrio, Amturnide United States Hypertension null 2010-12-21 Hypertension; Essential Hypertension Details
Aliskiren Approved Details
Aliskiren Hemifumarate SPP-100; SPP-100A; SPP-100B; CGP-60536; CGP-60536B Approved Novartis Pharma Ag Enviage, Rasilez, Riprazo, Sprimeo, Tekturna, 锐思力 Mainland China Essential Hypertension Noden Pharma Dac 2007-03-05 Heart Failure; Diabetes Mellitus, Type 2; Glomerulonephritis, IGA; Coronary Artery Disease; Hypertension; Diabetic macular oedema; Cardiovascular Diseases; Essential Hypertension; Kidney Failure, Chronic Details

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
SP-20104 (Sarfez Pharmaceuticals) SP-20104 Phase 2 Clinical 1 A Pharma Gmbh Glomerulosclerosis, Focal Segmental Details
MT-2765 MT-2765 Phase 3 Clinical Mitsubishi Tanabe Pharma Corp Hypertension Details
Imarikiren hydrochloride TAK-272; SCO-272 Phase 2 Clinical Takeda Pharmaceutical Co Ltd Hypertension; Diabetic Nephropathies Details
ACT-077825 Act-AAA; MK-8141; ACT-077825 Merck & Co Inc, Actelion Pharmaceuticals Ltd Details
IONIS-AGT-LRx IONISAGTLRx; ISIS-757456; ISISAGTLRx Ionis Pharmaceuticals Inc Details
SPP-635 SPP-630; SPP-635 Novartis Pharma Ag Details
SPH-3127 SPH-3127 Phase 3 Clinical Mitsubishi Tanabe Pharma, Shanghai Pharmaceuticals Holding Co Ltd Kidney Diseases; Hypertension; Colitis, Ulcerative; Essential Hypertension Details

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