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OX40

요약

Name:Tumor necrosis factor receptor superfamily member 4
Target Synonym:ATC35 Antigen,OX40 Antigen,ACT35,IMD16,OX40,Receptors, OX40,ACT35 antigen,TNFRSF4,CD134,TNF Receptor Superfamily Member 4,TAX Transcriptionally-Activated Glycoprotein 1 Receptor,CD134 Antigen,TXGP1L,Tumor Necrosis Factor Receptor Superfamily, Member 4,Lymphoid Activation Antigene ACT35,OX40 Homologue,Tumor necrosis factor receptor superfamily member 4,Tax-Transcriptionally Activated Glycoprotein 1 Receptor,OX40 Cell Surface Antigen,OX40L receptor
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:20
Lastest Research Phase:Phase 3 Clinical

제품 리스트 비교 또는 구매

제품번호 제품 설명 구조 순도 특징
OX0-R52H9 Rat Rat OX40 / TNFRSF4 / CD134 Protein, His Tag
OX0-R52H9-structure
OX0-R52H9-sds
OX0-C82E9 Cynomolgus / Rhesus macaque Biotinylated Cynomolgus / Rhesus macaque OX40 / TNFRSF4 / CD134 Protein, His,Avitag™
OX0-C82E9-structure
OX0-C82E9-sds
OX0-M82E5 Mouse Biotinylated Mouse OX40 / TNFRSF4 / CD134 Protein, His,Avitag™
OX0-M82E5-structure
OX0-M82E5-sds
OX0-H5252 Human Human OX40 / TNFRSF4 / CD134 Protein, Mouse IgG2a Fc Tag, low endotoxin
OX0-H5252-structure
OX0-H5252-sds
OX0-M522b Marmoset Marmoset OX40 / TNFRSF4 / CD134 Protein, His Tag
OX0-M522b-structure
OX0-M522b-sds
TN4-H82E4 Human Biotinylated Human OX40 / TNFRSF4 / CD134 Protein, Avitag™,His Tag (MALS verified) (recommended for biopanning)
TN4-H82E4-structure
TN4-H82E4-sds
OX0-R5253 Rat Rat OX40 / TNFRSF4 / CD134 Protein, Fc Tag
OX0-R5253-structure
OX0-R5253-sds
OX0-R5254 Rabbit Rabbit OX40 / TNFRSF4 / CD134 Protein, Fc Tag
OX0-R5254-structure
OX0-R5254-sds
OX0-H82F7 Human Biotinylated Human OX40 Protein, Fc,Avitag™
OX0-H82F7-structure
OX0-H82F7-sds
OX0-C5251 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque OX40 / TNFRSF4 / CD134 Protein, Fc Tag
OX0-C5251-structure
OX0-C5251-sds
OX0-C5220 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque OX40 / TNFRSF4 / CD134 Protein, His Tag
OX0-C5220-structure
OX0-C5220-sds
OX0-M5259 Mouse Mouse OX40 / TNFRSF4 / CD134 Protein, Fc Tag
OX0-M5259-structure
OX0-M5259-sds
OX0-M5228 Mouse Mouse OX40 / TNFRSF4 / CD134 Protein, His Tag
OX0-M5228-structure
OX0-M5228-sds
OX0-H5224 Human Human OX40 / TNFRSF4 / CD134 Protein, His Tag (MALS verified)
OX0-H5224-structure
OX0-H5224-sds
OX0-H5255 Human Human OX40 / TNFRSF4 / CD134 Protein, Fc Tag
OX0-H5255-structure
OX0-H5255-sds

일부의 생물활성 데이터

OX0-H5252-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

FACS assay shows that recombinant Human OX40, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. OX0-H5252) can bind to 293T cell overexpressing human OX40L. The concentration of OX40 is 0.01 μg/mL (Routinely tested).

OX0-H82F7-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

FACS assay shows that recombinant Biotinylated Human OX40, Fc,Avitag (Cat. No. OX0-H82F7) can bind to 293T cell overexpressing human OX40L. The concentration of OX40 is 0.1 μg/mL (Routinely tested).

TN4-H82E4-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Biotinylated Human OX40, Avitag,His Tag (Cat. No. TN4-H82E4) on SA Biosensor, can bind Anti-OX40 MAb (Human IgG1) with an affinity constant of 0.115 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

TN4-H82E4-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Biotinylated Human OX40, Avitag,His Tag (Cat. No. TN4-H82E4) on SA Biosensor, can bind Human OX40 Ligand, His Tag (active trimer) (MALS verified) (Cat. No. OXL-H52Q8) with an affinity constant of 0.127 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

TNFRSF4,OX40,CD134,OX40L receptor,ACT35,TXGP1L

Background

Tumor necrosis factor receptor superfamily member 4 (TNFRSF4) is also known as ACT35 antigen, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor, CD antigen CD134, OX40. OX40 / TNFRSF4 contains four TNFR-Cys repeats. TNFRSF4 is receptor for TNFSF4 / OX40L / GP34 and can interacts with TRAF2, TRAF3 and TRAF5.

Clinical and Translational Updates

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
SAR-442970 SAR-442970 Phase 1 Clinical Sanofi Inflammation Details
SL-279252 TAK-252; SL-279252 Phase 1 Clinical Takeda Pharmaceutical Co Ltd, Shattuck Labs Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Carcinoma, Transitional Cell; Hodgkin Disease; Lymphoma, Large B-Cell, Diffuse; Melanoma; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung Details
SHR-1806 SHR-1806 Phase 1 Clinical Jiangsu Hengrui Medicine Co Ltd, Suzhou Suncadia Biopharmaceuticals Co Ltd Neoplasms Details
INBRX-106 ES-102; ES102; INBRX-106 Phase 1 Clinical Inhibrx Solid tumours Details
KN-052 KN-052 Phase 1 Clinical Suzhou Alphamab Co Ltd Solid tumours Details
BAT-6026 BAT-6026 Phase 1 Clinical Shanghai Cp Guojian Pharmaceutical Co Ltd, Bio-Thera Solutions Ltd Solid tumours Details
HFB-3010(HiFiBiO Therapeutics) HFB-3010; HFB-301001 Phase 1 Clinical HiFiBiO Therapeutics Solid tumours Details
Recombinant human anti-OX40 monoclonal antibody (Eucure Biopharma) YH-002 Phase 1 Clinical Eucure Pharmaceutical Technology (Beijing) Co Ltd Solid tumours Details
Vonlerolizumab RG-7888; MOXR-0916; RO-7021608 Genentech Inc Details
BMS-986178 BMS-986178 Bristol-Myers Squibb Company Details
Revdofilimab ABBV-368; PR-1628103 Abbvie Inc Details
ATOR-1015 ADC-1015; ATOR-1015 Alligator Bioscience Details
Cudarolimab IBI-101 Phase 1 Clinical Innovent Biologics(Suzhou) Co Ltd Neoplasms Details
Rocatinlimab KHK-4083; AMG-451 Kyowa Hakko Kirin Co Ltd, Amgen Inc Details
FS-120 FS-120 F-Star Details
Telazorlimab GBR-830; ISB-830 Glenmark Pharmaceuticals Ltd Details
Recombinant human anti-OX40 monoclonal antibody (Livzon Group) Phase 1 Clinical Livzon Pharmaceutical Group Inc Neoplasms Details
MEDI-6469 AGX-051; MEDI-6469 Phase 1 Clinical Agonox, Providence Cancer Center Liver Neoplasms; Head and Neck Neoplasms; Solid tumours; Breast Neoplasms; Prostatic Neoplasms; Colorectal Neoplasms; Lymphoma; Melanoma; Neoplasm Metastasis Details
Tavolimab MEDI-0562 Phase 1 Clinical Medimmune Solid tumours; Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck; Neoplasms, Squamous Cell; Carcinoma, Squamous Cell; Melanoma Details
Ivuxolimab PF-8600; PF-04518600 Phase 3 Clinical Pfizer Pharmaceuticals Ltd (China) Ovarian Neoplasms; Solid tumours; Carcinoma; Carcinoma, Renal Cell; Neoplasms; Triple Negative Breast Neoplasms; Breast Neoplasms; Lymphoma, Follicular; Carcinoma, Non-Small-Cell Lung Details
INCAGN-1949 INCAGN-1949 Phase 2 Clinical Agenus Inc, Ludwig Institute For Cancer Research Solid tumours; Neoplasms; Pancreatic Neoplasms; Neoplasm Metastasis Details
GSK3174998 GSK3174998; GSK 3174998; GSK-3174998 Phase 2 Clinical Glaxosmithkline Plc Neoplasms; Multiple Myeloma Details
BGB-A445 BGB-A445 Phase 1 Clinical Beigene Ltd Solid tumours Details
IMG-007 IMG-007 Phase 1 Clinical Hutchmed (China) Ltd Dermatitis, Atopic Details

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