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IL-4 R alpha

요약

Name:Interleukin-4 receptor subunit alpha
Target Synonym:Interleukin 4 Receptor,IL-4 Receptor Subunit Alpha,Interleukin 13 Receptor,IL4RA,Interleukin-4 Receptor Subunit Alpha,Interleukin-4 Receptor Alpha Chain,IL4R Nirs Variant 1,IL-4R Subunit Alpha,CD124 Antigen,Interleukin-4 Receptor alpha Subunit,IL4Rα,IL-4R-alpha,Soluble IL-4 receptor subunit alpha,582J2.1,Soluble IL-4R-alpha,IL-4-binding protein,IL-4RA,IL4-BP,sIL4Ralpha/prot,CD124,IL4R
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Approved

제품 리스트 비교 또는 구매

일부의 생물활성 데이터

ILR-H5253-ELISA
Human IL-4 R alpha, Fc TagHuman IL-4 R alpha, Fc Tag (Cat. No. ILR-H5253) ELISA bioactivity

Immobilized Human IL-4, Tag Free (Cat. No. IL4-H4218) at 5 μg/mL (100 μL/well)can bind Human IL-4 R alpha, Fc Tag (Cat. No. ILR-H5253) with a linear range of 1-20 ng/mL (QC tested).

ILR-H82F4-MALS-HPLC
Biotinylated Human IL-4 R alpha, Fc,Avitag (Cat. No. ) MALS images

The purity of Biotinylated Human IL-4 R alpha, Fc,Avitag (Cat. No. ILR-H82F4) is more than 90% and the molecular weight of this protein is around 120-147 kDa verified by SEC-MALS.

Bioactivity-ELISA
Biotinylated Human IL-4 R alpha, Fc,AvitagBiotinylated Human IL-4 R alpha, Fc,Avitag (Cat. No. ILR-H82F4) ELISA bioactivity

Immobilized ActiveMax® Human IL-4, Tag Free (Cat. No. IL4-H4218) at 5 μg/mL (100 μL/well) can bind Biotinylated Human IL-4 R alpha, Fc,Avitag (Cat. No. ILR-H82F4) with a linear range of 0.5-16 ng/mL (QC tested).

사용자 리뷰

Synonym Name

IL4R,CD124,IL4RA

Background

IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4Rα (CD124)subunit and the 70 kDa common cytokine γc chain (CD132).Interleukin 4 Receptor (IL4R) also known as CD124, IL4Rα and BSF receptor, is a  type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-­biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R can alternatively associate with IL­13Ra1 to form the type II receptor which is responsive to both IL­4 and IL­13. Interleukin-4 receptor has been shown to interact with SHC1.

Clinical and Translational Updates

Related Molecule

공개 약품 정보

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Dupilumab REGN-668; SAR-231893 Approved Sanofi, Regeneron Pharmaceuticals Inc 达必妥, Dupixent United States Eosinophilic Esophagitis Regeneron Pharmaceuticals 2017-03-28 Hypersensitivity, Immediate; Conjunctivitis, Allergic; Asthma; Sinusitis; Prurigo; Neurodermatitis; Urticaria; Pemphigoid, Bullous; Pulmonary Disease, Chronic Obstructive; Prostatic Neoplasms; Peanut Hypersensitivity; Keratoconjunctivitis; Scleroderma, Localized; Keloid; Dermatitis, Atopic; Hypersensitivity; Eczema; Angioedema; Milk Hypersensitivity; Aspergillosis, Allergic Bronchopulmonary; Pruritus; Meningitis; Alopecia Areata; Chronic Urticaria; Nasal Polyps; Respiration Disorders; Netherton Syndrome; Eosinophilic gastroenteritis (EG); Respiratory Tract Diseases; Coronavirus Disease 2019 (COVID-19); Dermatitis; Skin Diseases; Genetic Diseases, Inborn; Skin Diseases, Eczematous; Eosinophilic Esophagitis; Rhinitis, Allergic Details

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
Sorafenib Tosylate/MG-K10 MG-D-1609 Phase 2 Clinical Metagone Biotech Solid tumours Details
Interleukin-4(38-37)-PE38KDEL MDNA-55; IL4-PE; NBI-3001; PRX-321 Neurocrine Biosciences, National Institute of Health, Islamabad Details
Recombinant anti-IL-4Rα humanized monoclonal antibody (Sansheng Guojian) 611 Phase 2 Clinical Shanghai Cp Guojian Pharmaceutical Co Ltd Dermatitis, Atopic Details
SHR-1819 SHR-1819 Phase 1 Clinical Jiangsu Hengrui Medicine Co Ltd Asthma; Dermatitis, Atopic Details
LQ-036 LQ-036 Phase 1 Clinical Shanghai Novamab Biopharmaceuticals Co Ltd Asthma Details
Elarekibep PRS-060/AZD1402; PRS-060; AZD-1402 University Of Melbourne, Pieris Pharmaceuticals Details
AMG-317 AMG-317 Amgen Inc Details
Manfidokimab AK-120 (Akeso ) Phase 2 Clinical Zhongshan Akeso Biopharma Co Ltd Asthma; Dermatitis, Atopic Details
CBP-201 CBP-201 Phase 2 Clinical Nasal Polyps; Nose Diseases; Asthma; Sinusitis; Status Asthmaticus; Dermatitis, Atopic Details
QX-005N QX-005N Phase 2 Clinical Qyuns Therapeutics Co Ltd Chronic Urticaria; Asthma; Prurigo; Sinusitis; Dermatitis, Atopic Details
MG-K10 MG-K10; MG-010; MG-K-10; BC-005 Phase 2 Clinical Dragonboat Biopharmaceutical, Shanghai Mabgeek Biotechnology Co Ltd Asthma; Dermatitis, Atopic Details
CM-310 CM-310 Phase 3 Clinical Keymed Biosciences Co Ltd, CSPC Pharmaceutical Group Ltd Solid tumours; Pruritus; Nose Diseases; Nasal Polyps; Rhinitis, Allergic; Asthma; Sinusitis; Dermatitis, Atopic Details

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