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IL-2

요약

Name:Interleukin-2
Target Synonym:T-cell growth factor,IL2,Interleukin 2,T Cell Growth Factor,Aldesleukin,IL-2,TCGF,Involved In Regulation Of T-Cell Clonal Expansion,Interleukin-2,Lymphokine
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:39
Lastest Research Phase:Approved

제품 리스트 구매

일부의 생물활성 데이터

GMP-L02H14F002-Cell-based assay
 IL-2 CELL

GMP Human IL-2 Protein (Liquid) (Cat. No. GMP-L02H14F002) stimulates proliferation of CTLL-2 cells. The specific activity of GMP Human IL-2 Protein (Liquid) is ≥ 1.20 × 10^7 IU/mg, which is calibrated against human Interleukin-2 China National Standard (NIFDC code: 270008) (QC tested). China National Institutes for Food and Drug Control (NIFDC) Standard was prepared and calibrated against human IL-2 WHO International Standard (NIBSC code: 86/500) by NIFDC.

GMP-L02H14-Cell-based assay
 IL-2 CELL

GMP Human IL-2 Protein (Cat. No. GMP-L02H14) stimulates proliferation of CTLL-2 cells. The specific activity of GMP Human IL-2 Protein is ≥ 1.20×10^7 IU/mg, which is calibrated against human Interleukin-2 China National Standard (NIFDC code: 270008) (QC tested). China National Institutes for Food and Drug Control (NIFDC) Standard was prepared and calibrated against human IL-2 WHO International Standard (NIBSC code: 86/500) by NIFDC.

IL2-C5249-SPR
 IL-2 SPR

Cynomolgus IL-2 R beta, His Tag (Cat. No. ILB-C52H9) immobilized on CM5 Chip can bind Cynomolgus IL-2, His Tag (Cat. No. IL2-C5249) with an affinity constant of 377 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

IL2-M52H3-SPR
 IL-2 SPR

Mouse IL-2, His Tag (Cat. No. IL2-M52H3) immobilized on CM5 Chip can bind Mouse IL-2 R beta, Fc Tag (Cat. No. ILB-M5253) with an affinity constant of 36.2 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

사용자 리뷰

Synonym Name

IL2,TCGF,lymphokine,Interleukin 2

Background

Interleukin-2 (IL-2) is an interleukin, a type of cytokine immune system signaling molecule, which is a leukocytotrophic hormone that is instrumental in the body's natural response to microbial infection and in discriminating between foreign (non-self) and self. IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes, the cells that are responsible for immunity. Mature human IL-2 shares 56% and 66% aa sequence identity with mouse and rat IL-2, respectively. Human and mouse IL-2 exhibit crossspecies activity. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is also necessary during T cell development in the thymus for the maturation of a unique subset of T cells that are termed regulatory T cells (T-regs). After exiting from the thymus, T-Regs function to prevent other T cells from recognizing and reacting against "self antigens", which could result in "autoimmunity". T-Regs do so by preventing the responding cells from producing IL-2. Thus, IL-2 is required to discriminate between self and non-self, another one of the unique characteristics of the immune system.

Clinical and Translational Updates

공개 약품 정보

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Thalidomide NSC-66847; NSC-527179; K-17; FPF-300; FPF300 Approved Celgene Corp Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled Mainland China Leprosy, Lepromatous; Multiple Myeloma Changzhou Pharmaceutical Factory 1982-01-01 Xerostomia; Colorectal Neoplasms; Neuroectodermal Tumors, Primitive; Prostatitis; Primary Myelofibrosis; Osteosarcoma; Cholangitis, Sclerosing; Lymphoma, Mantle-Cell; Lymphoma, Follicular; Adenocarcinoma, Clear Cell; Carcinoma, Adenosquamous; Epilepsy; Erythema Nodosum; Sarcoma; HIV Wasting Syndrome; Pancreatitis, Chronic; Sarcoma, Ewing; Arachnoiditis; Gastrointestinal Hemorrhage; Retinoblastoma; Prostatic Neoplasms; Endometriosis; Lung Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Vascular Malformations; Myelodysplastic-Myeloproliferative Diseases; Mycobacterium avium-intracellulare Infection; Amyotrophic Lateral Sclerosis; Carcinoma, Hepatocellular; Burning Mouth Syndrome; Stomatitis; Neoplasm Metastasis; Appendiceal Neoplasms; Tuberculosis; Lymphoma, Non-Hodgkin; Angiodysplasia; Pelvic Pain; Glioma; Waldenstrom Macroglobulinemia; Leprosy, Lepromatous; Endometrial Neoplasms; Uterine Neoplasms; Anemia, Sideroblastic; Ovarian Neoplasms; Gastric Antral Vascular Ectasia; Lupus Erythematosus, Discoid; Carc Details

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
Darleukin/fibromun L19-IL-2/ L19-TNF-α Phase 3 Clinical Philogen Spa Carcinoma, Merkel Cell; Carcinoma, Basal Cell; Carcinoma, Skin Appendage; Keratoacanthoma; Basal Cell Nevus Syndrome; Carcinoma, Squamous Cell; Lymphoma, T-Cell, Cutaneous; Melanoma; Sarcoma, Kaposi Details
Bifikafusp alfa L19-IL-2 Phase 3 Clinical Philogen Spa Solid tumours; Adenomatous Polyposis Coli; Pancreatic Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung Details
EQ-101 EQ101; EQ-101; BNZ132-1-40; BNZ-1; BNZ132-1; BNZ-01 Phase 2 Clinical Bioniz Therapeutics Inc Alopecia; Alopecia Areata; Lymphoma, T-Cell, Cutaneous; Leukemia, Large Granular Lymphocytic Details
umitrelimorgene autodencel ITI-1000 Phase 2 Clinical Immunomic Therapeutics Inc Glioblastoma Details
S-95007 S-95007 Phase 2 Clinical Laboratoires Servier Immune System Diseases; Inflammation Details
AU-007 BD-8; AU-007; BDG-8 Phase 2 Clinical Biolojic Design Inc Solid tumours; Neoplasms; Neoplasm Metastasis Details
XTX-202 XTX-202 Phase 2 Clinical Xilio Development Inc, Xilio Therapeutics Inc Solid tumours; Carcinoma, Renal Cell; Melanoma Details
EGL-001 EGL-001 Phase 2 Clinical Egle Therapeutics Solid tumours; Neoplasms Details
STI-7349 STI-7349 Phase 2 Clinical The Fourth Affiliated Hospital, Zhejiang University School Of Medcine Solid tumours Details
LAT-010 LAT010; LAT-010 Phase 2 Clinical Latticon Antibody Therapeutics Inc Solid tumours; Neoplasm Metastasis Details
COYA-302 COYA302; COYA 302; COYA-302 Phase 2 Clinical Coya Therapeutics Inc Parkinson Disease; Frontotemporal Dementia; Amyotrophic Lateral Sclerosis Details
KB-707 KB707; KB-707 Phase 2 Clinical Krystal Biotech Inc Solid tumours; Skin Melanoma; Neoplasms; Lung Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung Details
REGN-10597 REGN-10597 Phase 2 Clinical Regeneron Pharmaceuticals Inc Solid tumours; Carcinoma, Renal Cell; Neoplasms; Melanoma Details
IBI-363 IBI-363 Phase 2 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours; Stomach Neoplasms; Carcinoma, Renal Cell; Neoplasms; Colorectal Neoplasms; Lymphoma; Carcinoma, Non-Small-Cell Lung; Melanoma Details
Saltikva MDB401B Phase 2 Clinical Salspera LLC, Sunshine Lake Pharma Pancreatic Neoplasms Details
LMBP2-specific TCR-T cell therapy (TCRCure Biopharma) Phase 2 Clinical Tcrcure Biopharma Ltd Nasopharyngeal Carcinoma Details
Interleukin-2 gene therapy (St Jude Children's Research Hospital) Phase 1 Clinical St. Jude Children'S Research Hospital, National Cancer Institute Neuroblastoma Details
T20K T-20K Phase 1 Clinical Cyxone Multiple Sclerosis Details
ODC-IL2 ODC-IL2; ODC-IL-2 Phase 1 Clinical Trutino Biosciences Inc Solid tumours; Neoplasms Details
SIM-0278 ALM-223; SIM0278 Phase 1 Clinical Simcere Pharmaceutical Group Ltd Autoimmune Diseases; Lupus Erythematosus, Systemic; Dermatitis, Atopic Details
Mableukin 2PD1 (Anwita Biosciences) AWT020; AWT-020 Phase 1 Clinical Anwita Biosciences Inc Neoplasms; Autoimmune Diseases of the Nervous System Details
AB-248 AB-248 Phase 1 Clinical Asher Biotherapeutics Inc Solid tumours; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Non-Small-Cell Lung; Melanoma Details
ASP-1012 VET2-L2; ASP-1012; ASP1012 Phase 1 Clinical KaliVir Immunotherapeutics Inc Solid tumours Details
STK-012 STK-012 Phase 1 Clinical Synthekine Inc Solid tumours; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Esophageal Neoplasms; Stomach Neoplasms; Mismatch Repair Deficient Cancer; Carcinoma, Transitional Cell; Microsatellite instability-high cancer; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma Details
TEV-278 TEV-278; TEV-‘278 Phase 1 Clinical Teva Pharmaceutical Industries Ltd Neoplasms Details
HM-16390 HM-16390; HM16390 Phase 1 Clinical Hanmi Pharmaceutical Co Ltd Solid tumours Details
IL2 CD25 fusion protein (Bristol-Myers Squibb) Phase 1 Clinical University Of Miami Autoimmune Diseases Details
M5A-IL2 Immunocytokine M5A-ICK Phase 1 Clinical National Cancer Institute, City Of Hope National Medical Center Breast Neoplasms; Colorectal Neoplasms Details
DF-6215 DF6215; DF-6215 Phase 1 Clinical Dragonfly Therapeutics Llc Solid tumours Details
Dodekin Phase 1 Clinical Philogen Spa Solid tumours Details
AttIL2-T cell therapy Phase 1 Clinical The University Of Texas MD Anderson Cancer Center Soft Tissue Neoplasms; Osteosarcoma; Sarcoma Details
Autologous tumor-infiltrating lymphocyte cells therapy (Hervor Therapeutics) HV-101; HV101 Phase 1 Clinical Hervor Therapeutics, Tcrcure Biopharma Ltd, Hangzhou Houwu Biomedical Technology Co Ltd Solid tumours Details
KY-0118 KY-0118; KY0118 Phase 1 Clinical Novatim Immune Therapeutics (Zhejiang) Co Ltd Solid tumours; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Neoplasms; Pancreatic Neoplasms; Colorectal Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung Details
VIS171 VIS-171; VIS171 Phase 1 Clinical Visterra Inc Alopecia Areata; Autoimmune Diseases; Glomerulosclerosis, Focal Segmental; Lupus Erythematosus, Systemic Details
MK-1484 MK-1484; SP-482 Phase 1 Clinical Merck & Co Inc, Sutro Biopharma Inc Solid tumours Details
SAR-444336 SAR-444336 Phase 1 Clinical Sanofi Inflammation Details
RS-2102 RS2102 Phase 1 Clinical Reistone Biopharma Co Ltd Dermatitis, Atopic Details
RG-6279 RG-6279 Phase 1 Clinical F. Hoffmann-La Roche Ltd Solid tumours Details
BNT-153 BNT-153 Phase 1 Clinical Biontech Se Solid tumours Details
Igrelimogene litadenorepvec PM-1016; PM1016; TILT-123 Phase 1 Clinical Tilt Biotherapeutics Ltd Ovarian Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Lung Neoplasms; Carcinoma, Hepatocellular; Melanoma Details

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