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IDH1

요약

Name:Isocitrate dehydrogenase [NADP] cytoplasmic
Target Synonym:Isocitrate Dehydrogenase [NADP] Cytoplasmic,IDH,EC 1.1.1.42,HEL-216,HEL-S-26,IDH1,Cytosolic NADP-Isocitrate Dehydrogenase,NADP(+)-Specific ICDH,IDP,Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic,IDCD,PICD,Isocitrate Dehydrogenase 1 (NADP+), Soluble,Isoci
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:9
Lastest Research Phase:Approved

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ID1-H51H8 Human Human IDH1 (R132C) Protein, His Tag (MALS verified)
ID1-H51H8-structure
ID1-H51H8-sds
ID1-H51H6 Human Human IDH1 Protein, His Tag (active enzyme, MALS verified)
ID1-H51H6-structure
ID1-H51H6-sds

일부의 생물활성 데이터

ID1-H51H8-MALS-HPLC
Human IDH1 (R132C), His Tag (Cat. No. ) MALS images

The purity of Human IDH1 (R132C), His Tag (Cat. No. ID1-H51H8) is more than 85% and the molecular weight of this protein is around 85-100 kDa verified by SEC-MALS.

  • Background
    The IDH enzymes catalyze the oxidative decarboxylation of isocitrate to alpha-ketoglutarate (α-KG), producing nicotinamide adenine dinucleotide phosphate (NADPH) in the process via the citric acid cycle. Eukaryotic cells express two distinct classes of IDHs that utilize either NAD or NADP as their cofactors and serve diverse biological functions. NAD-dependent IDH is localized to the mitochondrial matrix and is well known for its central role for energy production in the Krebs cycle. NADP-dependent IDHs are primarily located either in mitochondria or cytoplasm . Each NADP-dependent isozyme is a homodimer. Mutations of Arg132 of human IDH1 result in a reduced ability of the enzyme to convert isocitrate to alpha ‑ketoglutarate, but the enzyme acquires the ability to generate 2-hydroxyglutarate (2HG) from alpha‑ketoglutarate,2-HG is elevated in several tumor types, including a subset of AMLs.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

    ID1-H51H6-MALS-HPLC
    Human IDH1, His Tag (Cat. No. ) MALS images

    The purity of Human IDH1, His Tag (Cat. No. ID1-H51H6) is more than 85% and the molecular weight of this protein is around 90-100 kDa verified by SEC-MALS.

Bioactivity

Measured by the ability to oxidatively decarboxylate isocitrate to 2-oxoglutarate. The specific activity is >10000 pmol/min/μg, as measured under the described conditions (QC tested).

Synonym Name

IDH1,PICD,IDP

Background

Isocitrate dehydrogenase 1 (IDH1) is also known as Cytosolic NADP-isocitrate dehydrogenase (NADP(+)-specific ICDH), Oxalosuccinate decarboxylase and PICD, which is one of the Isocitrate dehydrogenases that can catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD+ as the electron acceptor and the other NADP+. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.

Clinical and Translational Updates

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